Low Levels of Cyclin D and Nonfunctional Rb Protein Affect cdk6 Association with Cyclin-Dependent Kinase Inhibitor p27Kip1

2001 ◽  
Vol 284 (1) ◽  
pp. 106-111 ◽  
Author(s):  
Taeg Kyu Kwon ◽  
Jong-Wook Park
Keyword(s):  
Kinase Inhibitor ◽  
Cyclin D ◽  
Cyclin Dependent Kinase ◽  
Rb Protein ◽  
Cyclin Dependent Kinase Inhibitor ◽  
Low Levels

scholarly journals Increased Expression of NPM1 Suppresses p27Kip1 Function in Cancer Cells

Cancers ◽  
2020 ◽  
Vol 12 (10) ◽  
pp. 2886
Author(s):  
Tatsuya Kometani ◽  
Takuya Arai ◽  
Taku Chibazakura
Keyword(s):  
Cancer Cells ◽  
Kinase Inhibitor ◽  
Cyclin Dependent Kinase ◽  
Significant Suppression ◽  
Mouse Xenograft ◽  
Cyclin Dependent Kinase Inhibitor ◽  
Xenograft Models ◽  
Low Levels ◽  
Proteomic Screening

p27Kip1, a major cyclin-dependent kinase inhibitor, is frequently expressed at low levels in cancers, which correlates with their malignancy. However, in this study, we found a qualitative suppression of p27 overexpressed in some cancer cells. By proteomic screening for factors interacting with p27, we identified nucleophosmin isoform 1 (NPM1) as a novel p27-interacting factor and observed that NPM1 protein was expressed at high levels in some cancer cells. NPM1 overexpression in normal cells suppressed p27 function, and conversely, NPM1 knockdown in cancer cells restored the function in vitro. Furthermore, the tumors derived from cancer cells carrying the combination of p27 overexpression and NPM1 knockdown constructs showed significant suppression of growth as compared with those carrying other combinations in mouse xenograft models. These results strongly suggest that increased expression of NPM1 qualitatively suppresses p27 function in cancer cells.

scholarly journals Sensitivity of human meningioma cells to the cyclin-dependent kinase inhibitor, TG02

2020 ◽  
Vol 13 (12) ◽  
pp. 100852
Author(s):  
Caroline von Achenbach ◽  
Emilie Le Rhun ◽  
Felix Sahm ◽  
Sophie S. Wang ◽  
Philipp Sievers ◽  
...  
Keyword(s):  
Kinase Inhibitor ◽  
Cyclin Dependent Kinase ◽  
Cyclin Dependent Kinase Inhibitor ◽  
Human Meningioma
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