Inactivation of NF-κB Involved in Osteoblast Development through Interleukin-6

2001 ◽  
Vol 282 (5) ◽  
pp. 1080-1084 ◽  
Author(s):  
Yoshiaki Deyama ◽  
Sadaaki Takeyama ◽  
Kuniaki Suzuki ◽  
Yoshitaka Yoshimura ◽  
Makoto Nishikata ◽  
...  
Keyword(s):  
Interleukin 6 ◽  
Osteoblast Development

scholarly journals Interleukin 6 and Interleukin 17a Enhance Proliferation and Differentiation of Murine Osteoblast and Human Foetal Osteoblast Cell Lines

2020 ◽  
Vol 13 (2) ◽  
Author(s):  
Shaminea S ◽  
Kannan TP ◽  
Norazmi MN ◽  
Nurul AA
Keyword(s):  
Cell Lines ◽  
Interleukin 6 ◽  
Dependent Manner ◽  
Interleukin 17A ◽  
Proliferation And Differentiation ◽  
Osteoblast Development ◽  
Dose Dependent ◽  
Great Focus ◽  
Foetal Osteoblast ◽  
Hfob Cell

Introduction: Cytokines have been gaining great focus due to their role in enhancing osseointegration as well as their potential in bone reconstruction. Osseointegration often faces complications in its compatibility with the implant due to rejection by the recipients own immune system. Therefore, extensive studies are being carried out to enhance osteoblast development to minimize such complication. The aim of this study was to determine the effect of different concentrations of Interleukin 6 (IL-6) and Interleukin 17a (IL-17A) in the proliferation and differentiation of murine and human osteoblasts. Methods: Various concentrations (5, 10, 25 and 50 ng/ml) of rIL-6 and rIL-17A were tested on both murine osteoblast (MC3T3-E1) and human feotal osteoblast (hFOB) cell lines using [3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium] (MTS) and alkaline phosphatise (ALP) assays. MTS was carried out at 24, 48, 72, 96 and 120 hours while ALP assay was done on day 1, 3, 7, 10 and 14. Results: MC3T3-E1 cells showed steadier proliferation and differentiation compared to hFOB. Both cell lines expressed responses in dose-dependent manner. The concentration of 10ng for IL-6 and IL-17A in the case of MC3T3-E1 cell line was found to be the most suitable for further studies. Conclusion: IL-6 and IL-17A enhance proliferation and ALP activity of both MC3T3-E1 and hFOB cell lines.

419: Growth of the Prostate Cancer Xenograft Lncap-IL-6+ is Inhibited by an Anti-Interleukin-6 Monoclonal Antibody

2005 ◽  
Vol 173 (4S) ◽  
pp. 114-114
Author(s):  
Hannes Steiner ◽  
Ilaria T.R. Cavarretta ◽  
Andreas P. Berger ◽  
Jasmin Bektic ◽  
Marian Nakada ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Monoclonal Antibody ◽  
Interleukin 6

Retinoid regulation of interleukin-6 in human endometrial cells

1998 ◽  
Vol 5 (1) ◽  
pp. 108A-108A
Author(s):  
S SAWATSRI ◽  
R RAZDAN ◽  
N DESAI ◽  
N SIDELL
Keyword(s):  
Interleukin 6 ◽  
Endometrial Cells
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