Expression of Anaphase-Promoting Complex 5 in Balloon Angioplasty-Injured Rat Carotid Arteries and Mitogen-Stimulated Human Vascular Smooth Muscle Cells

2001 ◽  
Vol 282 (3) ◽  
pp. 723-728 ◽  
Author(s):  
Michael V. Autieri
Keyword(s):  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Vascular Smooth Muscle Cells ◽  
Balloon Angioplasty ◽  
Carotid Arteries ◽  
Muscle Cells ◽  
Anaphase Promoting Complex

Nonselective ETA/ETB receptor antagonist blocks proliferation of rat vascular smooth muscle cells after balloon angioplasty

Life Sciences ◽  
1995 ◽  
Vol 56 (25) ◽  
pp. PL449-PL454 ◽  
Author(s):  
Motoyoshi Tsujino ◽  
Yukio Hirata ◽  
Satoru Eguchi ◽  
Toshifumi Watanabe ◽  
Fumio Chatani ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Receptor Antagonist ◽  
Vascular Smooth Muscle Cells ◽  
Balloon Angioplasty ◽  
Muscle Cells ◽  
Etb Receptor

Dihydroartemisinin ameliorates balloon injury-induced neointimal formation through suppressing autophagy in vascular smooth muscle cells

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Xiaoyuan Wang ◽  
Junpeng Wu ◽  
Haiyang Zhang ◽  
Bei Sun ◽  
Renping Huang
Keyword(s):  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Vascular Smooth Muscle Cells ◽  
Carotid Arteries ◽  
Muscle Cells ◽  
Therapeutic Effects ◽  
Balloon Injury ◽  
Neointimal Formation ◽  
Phenotypic Transition

Abstract The present study was designed to investigate the therapeutic effects of injection of dihydroartemisinin (DHA) into the balloon-injured carotid arteries on balloon injury-induced neointimal formation and to explore whether autophagy is involved in the action of DHA. Percutaneous transluminal balloon angioplasty was performed in Sprague-Dawley rats to induce neointimal formation, immediately after which DHA (100 μmol/l×1 ml) and/or Rapamycin (1 mg/100 μl), were injected into the balloon-injured carotid arteries. After 14 d, the serum samples and carotid artery tissues were harvested for analysis. Rat aortic vascular smooth muscle cells (VSMCs) were pretreated with DMSO (vehicle), DHA (1, 10, and 100 μmol/l), or 3-methyladenine (3-MA; 10 mM) for 1 h and then stimulated with plateletderived growth factor-BB (PDGF-BB; 10 ng/ml) for another 24 h. Animal experiments showed that DHA attenuated the balloon injury-induced neointimal formation, inflammation and VSMC phenotypic transition by inhibiting the balloon injury-induced autophagy activation. In vitro results showed that DHA attenuated the PDGF-BB-induced VSMC phenotypic transition, proliferation, and migration by inhibiting the PDGF-BB-induced autophagy activation. Taken together, DHA ameliorates balloon injury-induced neointimal formation through suppressing autophagy. This study provides insights into the development of a drug-eluting stent using DHA.

Suppressive activities and mechanisms of ugonin J on vascular smooth muscle cells and balloon angioplasty-induced neointimal hyperplasia

2017 ◽  
Vol 32 (2) ◽  
pp. 312-320 ◽  
Author(s):  
Chun-Hsu Pan ◽  
Pei-Chuan Li ◽  
Yi-Chung Chien ◽  
Wan-Ting Yeh ◽  
Chih-Chuang Liaw ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Vascular Smooth Muscle Cells ◽  
Balloon Angioplasty ◽  
Neointimal Hyperplasia ◽  
Muscle Cells
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