Cell Density-Dependent Regulation of Hepatic Development by a gp130-Independent Pathway

2000 ◽  
Vol 277 (1) ◽  
pp. 152-158 ◽  
Author(s):  
Nobuhiko Kojima ◽  
Taisei Kinoshita ◽  
Akihide Kamiya ◽  
Koji Nakamura ◽  
Kinichi Nakashima ◽  
...  
Keyword(s):  
Cell Density ◽  
Density Dependent ◽  
Hepatic Development ◽  
Density Dependent Regulation

Cell-density-dependent regulation of streptococcal competence

2009 ◽  
pp. 233-268
Author(s):  
M. Dilani Senadheera ◽  
Celine Levesque ◽  
Dennis G. Cvitkovitch
Keyword(s):  
Cell Density ◽  
Density Dependent ◽  
Density Dependent Regulation

scholarly journals Expression of the leucocyte common antigen-related (LAR) tyrosine phosphatase is regulated by cell density through functional E-cadherin complexes

2002 ◽  
Vol 365 (2) ◽  
pp. 513-519 ◽  
Author(s):  
Javelle R. SYMONS ◽  
Charles M. LeVEA ◽  
Robert A. MOONEY
Keyword(s):  
Cell Density ◽  
Contact Inhibition ◽  
Mammary Adenocarcinoma ◽  
Low Density ◽  
Common Antigen ◽  
Regulation Of Expression ◽  
Density Dependent ◽  
Protein Levels ◽  
Density Dependent Regulation ◽  
E Cadherin

The leucocyte common antigen-related phosphatase (LAR) has been implicated in receptor tyrosine kinase signalling pathways while also displaying cell-density-dependency and localization to adherens junctions. Whereas physiological substrates for LAR have not been identified unequivocally, β-catenin associates with LAR and is a substrate in vitro. With the implication that LAR may play a role in regulating E-cadherin-dependent cell—cell communication and contact inhibition, the relationship of LAR with E-cadherin was investigated. LAR expression increased with cell density in the human breast cancer cell line MCF-7 and in Ln 3 cells derived from the 13762NF rat mammary adenocarcinoma. LAR protein levels decreased rapidly when cells were replated at a low density after attaining high expression of LAR at high cell density. COS-7 cells displayed comparable density-dependent regulation of LAR expression when transiently expressing exogenous LAR under the control of a constitutively active promoter, indicating that the regulation of expression is not at the level of gene regulation. Disrupting homophilic E-cadherin complexes by chelating extracellular calcium caused a marked decrease in LAR protein levels. Similarly, blocking E-cadherin interactions with saturating amounts of E-cadherin antibody (HECD-1) also led to a rapid and pronounced loss of cellular LAR. In contrast, mimicking cell-surface E-cadherin engagement by plating cells at low density on to dishes coated with HECD-1 resulted in a 2-fold increase in LAR expression compared with controls. These results suggest that density-dependent regulation of LAR expression is mediated by functional E-cadherin and may play a role in density-dependent contact inhibition by regulating tyrosine phosphorylation in E-cadherin complexes.

scholarly journals Perspectives on Quorum sensing in Fungi

2015 ◽  
Author(s):  
Sarangam Majumdar ◽  
Subhoshmita Mondal
Keyword(s):  
Quorum Sensing ◽  
Cell Density ◽  
Density Dependent ◽  
Sensing Systems ◽  
Fungal Kingdom ◽  
Density Dependent Regulation

Keeping a pace with Quorum sensing, analyzing communication shows the close co-evolution of fungi with organisms present in their environment giving insights into multispecies communication. Subsequently, many examples of cell density dependent regulation by extracellular factors have been found in diverse microorganisms. The widespread incidence of diverse quorum-sensing systems strongly suggests that regulation in accordance with cell density is important for the success of microbes in many environments. The paper includes the basic autoregulatory quorum sensing molecules that has been perceived. Although fungal quorum sensing research is still in its infancy, its discovery has changed our views about the fungal kingdom and could eventually lead to the development of new antifungal therapeutics.

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