Vitamin D Induced Up-Regulation of Keratinocyte Growth Factor (FGF-7/KGF) in MCF-7 Human Breast Cancer Cells

2000 ◽  
Vol 273 (2) ◽  
pp. 675-680 ◽  
Author(s):  
Alex Lyakhovich ◽  
Nickolai Aksenov ◽  
Pasi Pennanen ◽  
Susanna Miettinen ◽  
Merja H. Ahonen ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Vitamin D ◽  
Growth Factor ◽  
Cancer Cells ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Keratinocyte Growth Factor ◽  
Human Breast Cancer Cells ◽  
Human Breast ◽  
Mcf 7

scholarly journals Analogs of GnRH-I and GnRH-II inhibit epidermal growth factor-induced signal transduction and resensitize resistant human breast cancer cells to 4OH-tamoxifen

2005 ◽  
Vol 153 (4) ◽  
pp. 613-625 ◽  
Author(s):  
Andreas R Günthert ◽  
Carsten Gründker ◽  
Agnes Olota ◽  
Julia Läsche ◽  
Nicola Eicke ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Growth Factor ◽  
Cancer Cells ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Human Breast Cancer Cells ◽  
Human Breast ◽  
Antiproliferative Effects ◽  
Epidermal Growth ◽  
Mcf 7

About 50–64% of human breast cancers express receptors for GnRH-I. Direct antiproliferative effects of analogs of GnRH-I on human breast cancer cell lines have been shown. They are at least in part mediated by antagonizing growth promoting effects of estradiol, epidermal growth factor (EGF) or insulin-like growth factor. Recently, expression of a putative receptor for GnRH-II in human tissues was demonstrated. Antiproliferative effects of GnRH-II in human endometrial and ovarian cancer cells were shown not to be mediated through the GnRH-I receptor. Now we demonstrate direct anti-proliferative effects of the GnRH-I analog Triptorelin and the GnRH-II analog [d-Lys6]GnRH-II in MCF-7 and T47D human breast cancer cells expressing GnRH-I receptors and putative GnRH-II receptors. Pretreatment with Triptorelin or [d-Lys6]GnRH-II blocked EGF-induced autophosphoryla-tion of EGF receptor and activation of mitogen-activated protein kinase (extracellular-signal-regulated kinase 1/2 (ERK1/2)) in these cells. In sublines of MCF-7 and T47D cells, which were developed to be resistant to 4OH-tamoxifen, HER-2/p185 was overexpressed. Pretreatment of these cell lines with Triptorelin or [d-Lys6]GnRH-II completely abolished resistance to 4OH-tamoxifen, assessed by 4OH-tamoxifen-induced apoptosis. Analogs of GnRH-I and GnRH-II counteract EGF-dependent signal transduction in human breast cancer cells with expression of receptors for GnRH-I and GnRH-II. Through this mechanism, they probably reverse acquired resistance to 4OH-tamoxifen mediated through overexpression or activation of receptors of the c-erbB family.

scholarly journals Insulin-Like Growth Factor-Binding Protein 3 Induces Caspase-Dependent Apoptosis through a Death Receptor-Mediated Pathway in MCF-7 Human Breast Cancer Cells

2004 ◽  
Vol 64 (6) ◽  
pp. 2229-2237 ◽  
Author(s):  
Ho-Seong Kim ◽  
Angela R. Ingermann ◽  
Junko Tsubaki ◽  
Stephen M. Twigg ◽  
Gillian E. Walker ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Growth Factor ◽  
Cancer Cells ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Death Receptor ◽  
Human Breast Cancer Cells ◽  
Human Breast ◽  
Factor Binding ◽  
Mcf 7

The antiproliferative effect of vitamin D analogs on MCF-7 human breast cancer cells

1995 ◽  
Vol 92 (1) ◽  
pp. 77-82 ◽  
Author(s):  
Richard V. Brenner ◽  
Mohsen Shabahang ◽  
Lisa M. Schumaker ◽  
Russell J. Nauta ◽  
Milan R. Uskokovic ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Vitamin D ◽  
Cancer Cells ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Antiproliferative Effect ◽  
Human Breast Cancer Cells ◽  
Human Breast ◽  
Vitamin D Analogs ◽  
Mcf 7
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