Identification of an EDG7 Variant, HOFNH30, a G-Protein-Coupled Receptor for Lysophosphatidic Acid

2000 ◽  
Vol 273 (3) ◽  
pp. 805-810 ◽  
Author(s):  
Laura Rydelek Fitzgerald ◽  
George M. Dytko ◽  
Henry M. Sarau ◽  
Ishrat Jahan Mannan ◽  
Catherine Ellis ◽  
...  
Keyword(s):  
G Protein ◽  
Lysophosphatidic Acid ◽  
G Protein Coupled Receptor ◽  
G Protein Coupled

scholarly journals Induction of protein growth factor systems in the ovaries of transgenic mice overexpressing human type 2 lysophosphatidic acid G protein-coupled receptor (LPA2)

Oncogene ◽  
2004 ◽  
Vol 23 (1) ◽  
pp. 122-129 ◽  
Author(s):  
Mei-Chuan Huang ◽  
Hsin-Yu Lee ◽  
Che-Chung Yeh ◽  
Yvonne Kong ◽  
Charles J Zaloudek ◽  
...  
Keyword(s):  
Growth Factor ◽  
Transgenic Mice ◽  
G Protein ◽  
Lysophosphatidic Acid ◽  
G Protein Coupled Receptor ◽  
Human Type ◽  
G Protein Coupled

Effects of Antidepressants on G Protein–coupled Receptor Signaling and Viability in Xenopus laevis  Oocytes

2003 ◽  
Vol 99 (4) ◽  
pp. 911-917 ◽  
Author(s):  
Danja Strümper ◽  
Marcel E. Durieux ◽  
Barbara Tröster ◽  
Klaus Hahnenkamp ◽  
Cristina Vitan ◽  
...  
Keyword(s):  
Xenopus Laevis ◽  
G Protein ◽  
Lysophosphatidic Acid ◽  
Local Anesthetics ◽  
Xenopus Laevis Oocytes ◽  
Receptor Signaling ◽  
G Protein Coupled Receptor ◽  
Prolonged Incubation ◽  
Low Concentrations ◽  
G Protein Coupled

Background Tricyclic antidepressants are structurally related to local anesthetics, suggesting that part of their analgesic action may result from properties shared with local anesthetics. Because local anesthetics block G protein-coupled receptor signaling (which explains, in part, their inflammatory modulating properties), the authors studied whether antidepressants have similar effects. Methods Peak Ca-activated Cl currents induced in Xenopus laevis oocytes by lysophosphatidic acid (10(-4) m) were measured using a voltage clamp. The effects of a 30-, 120-, or 240-min incubation in amitriptyline, nortriptyline, imipramine, or fluoxetine were determined. Results After a 30-min incubation, low concentrations (10(-7)-10(-5) m) of antidepressants had no effect on lysophosphatidic acid-induced currents. After prolonged incubation, only amitriptyline or nortriptyline inhibited lysophosphatidic acid signaling (each to 58% of the control response at 10(-7) m after 240 min). At low concentrations, none of the compounds induced membrane damage (defined as a holding current of > 1 microA, 2% in control cells). Imipramine at 10(-3) m induced damage in 100% of oocytes, and fluoxetine at 10(-4) m induced damage in 71% of oocytes (P < 0.05 vs. control). Amitriptyline and nortriptyline had no effect. Conclusions These findings are in part different from those obtained with local anesthetics and suggest that interference with G protein-coupled signaling might explain, in part, the analgesic properties of some antidepressants. However, use of antidepressants in high concentrations may be associated with cellular toxicity.

scholarly journals Lysophosphatidic Acid Stimulates the G-protein-coupled Receptor EDG-1 as a Low Affinity Agonist

1998 ◽  
Vol 273 (34) ◽  
pp. 22105-22112 ◽  
Author(s):  
Menq-Jer Lee ◽  
Shobha Thangada ◽  
Catherine H. Liu ◽  
Brian D. Thompson ◽  
Timothy Hla
Keyword(s):  
G Protein ◽  
Lysophosphatidic Acid ◽  
G Protein Coupled Receptor ◽  
G Protein Coupled

scholarly journals Characterization of a Novel Subtype of Human G Protein-coupled Receptor for Lysophosphatidic Acid

1998 ◽  
Vol 273 (14) ◽  
pp. 7906-7910 ◽  
Author(s):  
Songzhu An ◽  
Thieu Bleu ◽  
Olivia G. Hallmark ◽  
Edward J. Goetzl
Keyword(s):  
G Protein ◽  
Lysophosphatidic Acid ◽  
G Protein Coupled Receptor ◽  
G Protein Coupled
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