Tissue-Specific Involvement of Multiple Mitochondrial DNA Deletions in Familial Mitochondrial Myopathy

1998 ◽  
Vol 247 (1) ◽  
pp. 24-27 ◽  
Author(s):  
Satoshi Nishizuka ◽  
Gen Tamura ◽  
Yu-ichi Goto ◽  
Kumiko Murayama ◽  
Toshiaki Konno ◽  
...  
Keyword(s):  
Mitochondrial Dna ◽  
Mitochondrial Myopathy ◽  
Tissue Specific ◽  
Dna Deletions

Mitochondrial myopathy: correlation between oxidative defect and mitochondrial DNA deletions at single fiber level

1994 ◽  
Vol 87 (4) ◽  
pp. 371-376 ◽  
Author(s):  
A. Prelle ◽  
G. Fagiolari ◽  
N. Checcarelli ◽  
M. Moggio ◽  
A. Battistel ◽  
...  
Keyword(s):  
Mitochondrial Dna ◽  
Mitochondrial Myopathy ◽  
Single Fiber ◽  
Dna Deletions

Widespread tissue distribution of multiple mitochondrial DNA deletions in familial mitochondrial myopathy

1994 ◽  
Vol 17 (7) ◽  
pp. 741-746 ◽  
Author(s):  
Shingo Kawashima ◽  
Shigeo Ohta ◽  
Yasuo Kagawa ◽  
Mitsuo Yoshida ◽  
Masatoyo Nishizawa
Keyword(s):  
Mitochondrial Dna ◽  
Tissue Distribution ◽  
Mitochondrial Myopathy ◽  
Dna Deletions

Mitochondrial myopathy: correlation between oxidative defect and mitochondrial DNA deletions at single fiber level

1994 ◽  
Vol 87 (4) ◽  
pp. 371-376
Author(s):  
A. Prelle ◽  
G. Fagiolari ◽  
N. Checcarelli ◽  
M. Moggio ◽  
A. Battistel ◽  
...  
Keyword(s):  
Mitochondrial Dna ◽  
Mitochondrial Myopathy ◽  
Single Fiber ◽  
Dna Deletions

Multiple mitochondrial DNA deletions in a patient with mitochondrial myopathy and cardiomyopathy but no ophthalmoplegia

1995 ◽  
Vol 18 (11) ◽  
pp. 1321-1325 ◽  
Author(s):  
Yo-Ichi Takei ◽  
Shu-Ichi Ikeda ◽  
Nobuo Yanagisawa ◽  
Wataru Takahashi ◽  
Morie Sekiguchi ◽  
...  
Keyword(s):  
Mitochondrial Dna ◽  
Mitochondrial Myopathy ◽  
Dna Deletions

Increased Mitochondrial DNA Deletions in Substantia Nigra Dopamine Neurons of the Aged Rat

2015 ◽  
Vol 7 (3) ◽  
pp. 155-160 ◽  
Author(s):  
Gemma M. Parkinson ◽  
Christopher V. Dayas ◽  
Doug W. Smith
Keyword(s):  
Mitochondrial Dna ◽  
Substantia Nigra ◽  
Dopamine Neurons ◽  
Aged Rat ◽  
Dna Deletions

scholarly journals Mitochondrial DNA Heteroplasmy as an Informational Reservoir Dynamically Linked to Metabolic and Immunological Processes Associated with COVID-19 Neurological Disorders

2021 ◽  
Author(s):  
George B. Stefano ◽  
Richard M. Kream
Keyword(s):  
Mitochondrial Dna ◽  
Mitochondrial Function ◽  
Neurological Disorders ◽  
Nuclear Dna ◽  
Mitochondrial Dynamics ◽  
Cell Types ◽  
Tissue Specific ◽  
Copy Numbers ◽  
The Central Nervous System ◽  
Mitochondrial Dna Heteroplasmy

AbstractMitochondrial DNA (mtDNA) heteroplasmy is the dynamically determined co-expression of wild type (WT) inherited polymorphisms and collective time-dependent somatic mutations within individual mtDNA genomes. The temporal expression and distribution of cell-specific and tissue-specific mtDNA heteroplasmy in healthy individuals may be functionally associated with intracellular mitochondrial signaling pathways and nuclear DNA gene expression. The maintenance of endogenously regulated tissue-specific copy numbers of heteroplasmic mtDNA may represent a sensitive biomarker of homeostasis of mitochondrial dynamics, metabolic integrity, and immune competence. Myeloid cells, monocytes, macrophages, and antigen-presenting dendritic cells undergo programmed changes in mitochondrial metabolism according to innate and adaptive immunological processes. In the central nervous system (CNS), the polarization of activated microglial cells is dependent on strategically programmed changes in mitochondrial function. Therefore, variations in heteroplasmic mtDNA copy numbers may have functional consequences in metabolically competent mitochondria in innate and adaptive immune processes involving the CNS. Recently, altered mitochondrial function has been demonstrated in the progression of coronavirus disease 2019 (COVID-19) due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Accordingly, our review is organized to present convergent lines of empirical evidence that potentially link expression of mtDNA heteroplasmy by functionally interactive CNS cell types to the extent and severity of acute and chronic post-COVID-19 neurological disorders.

Mitochondrial DNA deletions in the peripheral blood of workers at the Mayak PA who were exposed to long-term combined effects of external γ- and internal α-radiation

BIOPHYSICS ◽  
2016 ◽  
Vol 61 (6) ◽  
pp. 1026-1032
Author(s):  
L. V. Malakhova ◽  
M. G. Lomaeva ◽  
M. L. Zakharova ◽  
E. N. Kirillova ◽  
S. N. Sokolova ◽  
...  
Keyword(s):  
Mitochondrial Dna ◽  
Peripheral Blood ◽  
Combined Effects ◽  
Dna Deletions
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