Identification of the Hydrophobic Amino Acid Residues Required for Heme Assembly in the Rhizobial Oxygen Sensor Protein FixL

1998 ◽  
Vol 247 (2) ◽  
pp. 427-431 ◽  
Author(s):  
Hiro Nakamura ◽  
Ken Saito ◽  
Eiichi Ito ◽  
Koji Tamura ◽  
Terumasa Tsuchiya ◽  
...  
Keyword(s):  
Amino Acid ◽  
Oxygen Sensor ◽  
Amino Acid Residues ◽  
Hydrophobic Amino Acid ◽  
Sensor Protein

scholarly journals Mitigating the Adverse Effects of Polychlorinated Biphenyl Derivatives on Estrogenic Activity via Molecular Modification Techniques

2021 ◽  
Vol 18 (9) ◽  
pp. 4999
Author(s):  
Wei He ◽  
Wenhui Zhang ◽  
Zhenhua Chu ◽  
Yu Li
Keyword(s):  
Amino Acid ◽  
Binding Site ◽  
Hydrophobic Interaction ◽  
Oestrogen Receptor ◽  
Polychlorinated Biphenyl ◽  
Hydrophobic Interactions ◽  
Estrogenic Activity ◽  
Average Distance ◽  
Amino Acid Residues ◽  
Hydrophobic Amino Acid

The aim of this paper is to explore the mechanism of the change in oestrogenic activity of PCBs molecules before and after modification by designing new PCBs derivatives in combination with molecular docking techniques through the constructed model of oestrogenic activity of PCBs molecules. We found that the weakened hydrophobic interaction between the hydrophobic amino acid residues and hydrophobic substituents at the binding site of PCB derivatives and human oestrogen receptor alpha (hERα) was the main reason for the weakened binding force and reduced anti-oestrogenic activity. It was consistent with the information that the hydrophobic field displayed by the 3D contour maps in the constructed oestrogen activity CoMSIA model was one of the main influencing force fields. The hydrophobic interaction between PCB derivatives and oestrogen-active receptors was negatively correlated with the average distance between hydrophobic substituents and hydrophobic amino acid residues at the hERα-binding site, and positively correlated with the number of hydrophobic amino acid residues. In other words, the smaller the average distance between the hydrophobic amino acid residues at the binding sites between the two and the more the number of them, and the stronger the oestrogen activity expression degree of PCBS derivative molecules. Therefore, hydrophobic interactions between PCB derivatives and the oestrogen receptor can be reduced by altering the microenvironmental conditions in humans. This reduces the ability of PCB derivatives to bind to the oestrogen receptor and can effectively modulate the risk of residual PCB derivatives to produce oestrogenic activity in humans.

Enhanced stability of Cu2+–ATCUN complexes under physiologically relevant conditions by insertion of structurally bulky and hydrophobic amino acid residues into the ATCUN motif

2016 ◽  
Vol 45 (23) ◽  
pp. 9436-9445 ◽  
Author(s):  
Takaaki Miyamoto ◽  
Yuta Fukino ◽  
Shinichiro Kamino ◽  
Masashi Ueda ◽  
Shuichi Enomoto
Keyword(s):  
Amino Acid ◽  
Amino Acid Residues ◽  
Hydrophobic Amino Acid ◽  
Hydrophobic Residues ◽  
The Stability ◽  
Enhanced Stability

The stability of Cu2+–ATCUN complexes under physiologically relevant conditions is enhanced by inserting bulky and hydrophobic residues at positions 1 and 2 of the ATCUN peptide.

Freezing-induced exposure of hydrophobic amino acid residues from actomyosin.

1986 ◽  
Vol 52 (5) ◽  
pp. 859-862 ◽  
Author(s):  
Eiji Niwa ◽  
Shin-ichiro Kohda ◽  
Teruo Nakayama
Keyword(s):  
Amino Acid ◽  
Amino Acid Residues ◽  
Hydrophobic Amino Acid

Hydrophobic Amino Acid Residues of Human Anticoagulation Protein C That Contribute to Its Functional Binding to Phospholipid Vesicles

Biochemistry ◽  
1995 ◽  
Vol 34 (33) ◽  
pp. 10376-10382 ◽  
Author(s):  
William T. Christiansen ◽  
Louise R. Jalbert ◽  
Rolanda M. Robertson ◽  
Ashish Jhingan ◽  
Mary Prorok ◽  
...  
Keyword(s):  
Amino Acid ◽  
Protein C ◽  
Phospholipid Vesicles ◽  
Amino Acid Residues ◽  
Hydrophobic Amino Acid

Influence of hydrophobic amino acid residues on the esterification of dipeptides by papain

1989 ◽  
Vol 11 (7) ◽  
pp. 493-498 ◽  
Author(s):  
Dani�le Cantacuzene ◽  
Catherine Guerreiro ◽  
Sandra Attal
Keyword(s):  
Amino Acid ◽  
Amino Acid Residues ◽  
Hydrophobic Amino Acid
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