Selective Pituitary Resistance to Thyroid Hormone Produced by Expression of a Mutant Thyroid Hormone Receptor β Gene in the Pituitary Gland of Transgenic Mice

1998 ◽  
Vol 245 (1) ◽  
pp. 204-210 ◽  
Author(s):  
Yoshitaka Hayashi ◽  
Jun Xie ◽  
Roy E. Weiss ◽  
Joachim Pohlenz ◽  
Samuel Refetoff
Keyword(s):  
Thyroid Hormone ◽  
Transgenic Mice ◽  
Pituitary Gland ◽  
Hormone Receptor ◽  
Thyroid Hormone Receptor ◽  
Resistance To Thyroid Hormone ◽  
Thyroid Hormone Receptor Β

scholarly journals Thyroid hormone receptor β mutations in the ‘hot-spot region’ are rare events in thyroid carcinomas

2007 ◽  
Vol 192 (1) ◽  
pp. 83-86 ◽  
Author(s):  
Ana Sofia Rocha ◽  
Ricardo Marques ◽  
Inês Bento ◽  
Ricardo Soares ◽  
João Magalhães ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Thyroid Hormone ◽  
Transgenic Mice ◽  
Cell Lines ◽  
Hormone Receptor ◽  
Thyroid Hormone Receptor ◽  
Hot Spot ◽  
Direct Sequencing ◽  
Human Thyroid ◽  
Thyroid Hormone Receptor Β

Thyroid cancer constitutes the most frequent endocrine neoplasia. Targeted expression of rearranged during transfection (RET)/papillary thyroid carcinoma (PTC) and V600E V-raf murine sarcoma viral oncogene homolog B1 (BRAF) to the thyroid glands of transgenic mice results in tumours similar to those of human PTC, providing evidence for the involvement of these oncogenes in PTC. Kato et al. developed a mouse model that mimics the full spectrum of the human follicular form of thyroid cancer (FTC). FTC rapidly develops in these mice through introduction of the thyroid hormone receptor β (THRB)PV mutant on the background of the inactivated THRB wt locus. Our aim was to verify if, in the context of human follicular thyroid carcinogenesis, THRB acted as a tumour suppressor gene. We screened for mutations of the THRB gene in the hot-spot region, spanning exons 7–10, in 51 thyroid tumours and six thyroid cancer cell lines by PCR and direct sequencing. We did not find mutations in any of the tumours or cell lines analysed. Our findings suggest that, in contrast to the findings on the THRB-mutant transgenic mice, THRB gene mutations are not a relevant mechanism for human thyroid carcinogenesis.

A Novel Point Mutation of Thyroid Hormone Receptor β Gene in a Family with Resistance to Thyroid Hormone

Thyroid ◽  
1997 ◽  
Vol 7 (5) ◽  
pp. 771-773 ◽  
Author(s):  
TOMOHISA NAGASHIMA ◽  
HIDEKI YAGI ◽  
KANJI NAGASHIMA ◽  
AKIHIRO SAKURAI ◽  
KAZUMICHI ONIGATA ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Point Mutation ◽  
Hormone Receptor ◽  
Thyroid Hormone Receptor ◽  
Resistance To Thyroid Hormone ◽  
Thyroid Hormone Receptor Β

A Novel Resistance to Thyroid Hormone Associated with a New Mutation (T329N) in the Thyroid Hormone Receptor β Gene

Thyroid ◽  
1999 ◽  
Vol 9 (2) ◽  
pp. 165-171 ◽  
Author(s):  
GAIANE SARKISSIAN ◽  
ALEXANDRA DACE ◽  
ANNE MESMACQUE ◽  
HELENE BONY-TRIFUNOVIC ◽  
CHRISTIANE MALEZET-DESMOULINS ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Hormone Receptor ◽  
Thyroid Hormone Receptor ◽  
New Mutation ◽  
Resistance To Thyroid Hormone ◽  
Thyroid Hormone Receptor Β

scholarly journals ADe NovoMutation in an Already Mutant Nucleotide of the Thyroid Hormone Receptor β Gene Perpetuates Resistance to Thyroid Hormone

2005 ◽  
Vol 90 (3) ◽  
pp. 1760-1767 ◽  
Author(s):  
Joaquin Lado-Abeal ◽  
Alexandra M. Dumitrescu ◽  
Xiao-Hui Liao ◽  
Ronald N. Cohen ◽  
Joachim Pohlenz ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Hormone Receptor ◽  
Thyroid Hormone Receptor ◽  
Resistance To Thyroid Hormone ◽  
Thyroid Hormone Receptor Β

scholarly journals Reduced pituitary size in subjects with mutations in the THRB gene and thyroid hormone resistance

2021 ◽  
Author(s):  
Marcus Heldmann ◽  
Krishna Chatterjee ◽  
Carla Moran ◽  
Berenike Rogge ◽  
Julia Steinhardt ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Pituitary Gland ◽  
Hormone Receptors ◽  
Thyroid Hormone Receptor ◽  
Magnetic Resonance Images ◽  
Healthy Controls ◽  
Hormone Action ◽  
Resistance To Thyroid Hormone ◽  
Thyroid Hormone Action ◽  
Thyroid Hormone Receptor Β

Background: Thyroid hormone action is mediated by two forms of thyroid hormone receptors (α,β) with differential tissue distribution. Thyroid hormone receptor β (TRβ) mutations lead to resistance to thyroid hormone action in tissues predominantly expressing the β form of the receptor (pituitary, liver). This study seeks to identify effects of mutant TRβ on pituitary size. Methods: High-resolution 3D T1-weighted magnetic resonance images were acquired in 19 patients with RTHβ in comparison to 19 healthy matched controls. Volumetric measurements of the pituitary gland were performed independently and blinded by four different raters (two neuroradiologists, one neurologist, one neuroscientist). Results: Patients with mutant TRβ (Resistance to Thyroid Hormone β,RΤΗβ) showed elevated fT3/4 levels with normal TSH levels, whereas healthy controls showed normal thyroid hormone levels. Imaging revealed smaller pituitary size in RTHβ patients in comparison to healthy controls (F(1,35)=7.05, p=0.012, partial η2 =0.17). Conclusion: RTHβ subjects have impaired sensitivity to thyroid hormones, along with decreased size of the pituitary gland.

A novel missense mutation in the thyroid hormone receptor β gene in a kindred with resistance to thyroid hormone

1996 ◽  
Vol 97 (3) ◽  
pp. 407-408 ◽  
Author(s):  
Hiromichi Kijima ◽  
Mitsumasa Kubo ◽  
Tatsuya Ishizuka ◽  
Mitsuaki Kakinuma ◽  
Takao Koike
Keyword(s):  
Thyroid Hormone ◽  
Missense Mutation ◽  
Hormone Receptor ◽  
Thyroid Hormone Receptor ◽  
Resistance To Thyroid Hormone ◽  
Thyroid Hormone Receptor Β
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