Signal Transduction via CD43 (Leukosialin, Sialophorin) and Associated Biological Effects in a Human Mast Cell Line (HMC-1)

1998 ◽  
Vol 243 (1) ◽  
pp. 163-169 ◽  
Author(s):  
Magda Babina ◽  
Sylvia Weber ◽  
Kerstin Mammeri ◽  
Beate M. Henz
Keyword(s):  
Signal Transduction ◽  
Mast Cell ◽  
Cell Line ◽  
Biological Effects ◽  
Human Mast Cell ◽  
Mast Cell Line

scholarly journals Transcriptional complexity of the HSPG2 gene in the human mast cell line, HMC-1

2014 ◽  
Vol 35 ◽  
pp. 123-131 ◽  
Author(s):  
Megan S. Lord ◽  
MoonSun Jung ◽  
Bill Cheng ◽  
John M. Whitelock
Keyword(s):  
Mast Cell ◽  
Cell Line ◽  
Human Mast Cell ◽  
Mast Cell Line

Cytokine release from a human mast cell line (HMC-1) in response to stimulation with anti-IgE and other secretagogues

2000 ◽  
Vol 49 (S1) ◽  
pp. 7-8 ◽  
Author(s):  
J. Wierecky ◽  
J. Grabbe ◽  
H. H. Wolff ◽  
B. F. Gibbs
Keyword(s):  
Mast Cell ◽  
Cell Line ◽  
Human Mast Cell ◽  
Cytokine Release ◽  
Mast Cell Line

The Human Mast Cell Line HMC‐1 Expresses C5a Receptors and Responds to C5a but not to C5a(desArg)

1996 ◽  
Vol 44 (1) ◽  
pp. 30-36 ◽  
Author(s):  
T. WERFEL ◽  
M. OPPERMANN ◽  
J. H. BUTTERFIELD ◽  
G. BEGEMANN ◽  
J. ELSNER ◽  
...  
Keyword(s):  
Mast Cell ◽  
Cell Line ◽  
Human Mast Cell ◽  
C5a Receptors ◽  
Mast Cell Line

Quercetin inhibits expression of inflammatory cytokines through attenuation of NF-κB and p38 MAPK in HMC-1 human mast cell line

2007 ◽  
Vol 56 (5) ◽  
pp. 210-215 ◽  
Author(s):  
Y.-D. Min ◽  
C.-H. Choi ◽  
H. Bark ◽  
H.-Y. Son ◽  
H.-H. Park ◽  
...  
Keyword(s):  
Mast Cell ◽  
Cell Line ◽  
P38 Mapk ◽  
Inflammatory Cytokines ◽  
Human Mast Cell ◽  
Mast Cell Line

The potential anti-proliferative effect of β-sitosterol on human mast cell line-1 cells

2015 ◽  
Vol 93 (11) ◽  
pp. 979-983 ◽  
Author(s):  
Na-Ra Han ◽  
Hyung-Min Kim ◽  
Hyun-Ja Jeong
Keyword(s):  
Cell Proliferation ◽  
Mast Cell ◽  
Mrna Expression ◽  
Cell Line ◽  
Allergic Diseases ◽  
Human Mast Cell ◽  
Ki 67 ◽  
Proliferative Effect ◽  
P53 Activation ◽  
Mast Cell Line

Thymic stromal lymphopoietin (TSLP) was reported to induce mast cell proliferation and aggravate allergic reactions through activation of mouse double minute 2 (MDM2). We aimed to ascertain that β-sitosterol (SI), which is one of the several phytosterols found mostly in foods, would regulate TSLP-induced mast cell proliferation. The results showed that SI significantly decreased the proliferation of human mast cell line (HMC-1) cells promoted by TSLP. SI significantly decreased the mRNA expression of Ki-67 in the TSLP-treated HMC-1 cells. SI significantly suppressed the production and mRNA expression of interleukin-13 in the TSLP-treated HMC-1 cells. Furthermore, SI downregulated the expression of MDM2 and phosphorylation of STAT6, whereas it upregulated the expression of p53, activation of caspase-3, and cleavage of poly ADP-ribose polymerase in the TSLP-treated HMC-1 cells. Results of this study suggest that SI may be a potential therapeutic agent for mast cell-mediated allergic diseases.

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