The Voltage-Dependent Non-selective Cation Channel Sensitive to the L-Type Calcium Channel Blocker Efonidipine Regulates Ca2+Influx in Brain Vascular Smooth Muscle Cells

1997 ◽  
Vol 240 (2) ◽  
pp. 484-487 ◽  
Author(s):  
Toshiyuki Matsuoka ◽  
Tomoyuki Nishizaki ◽  
Tamotsu Nomura
Keyword(s):  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Calcium Channel ◽  
Calcium Channel Blocker ◽  
Vascular Smooth Muscle Cells ◽  
Channel Blocker ◽  
Muscle Cells ◽  
Cation Channel ◽  
Voltage Dependent

L‐type calcium channel expression depends on the differentiated state of vascular smooth muscle cells

1998 ◽  
Vol 12 (7) ◽  
pp. 593-601 ◽  
Author(s):  
Maik Gollasch ◽  
Hannelore Haase ◽  
Christian Ried ◽  
Carsten Lindschau ◽  
Ingo Morano ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Calcium Channel ◽  
Vascular Smooth Muscle Cells ◽  
Muscle Cells ◽  
Channel Expression

Altered L-type Ca2+ channel currents in vascular smooth muscle cells from experimental diabetic rats

2000 ◽  
Vol 278 (3) ◽  
pp. H714-H722 ◽  
Author(s):  
Rui Wang ◽  
Yuejin Wu ◽  
Guanghua Tang ◽  
Lingyun Wu ◽  
Salma Toma Hanna
Keyword(s):  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Vascular Smooth Muscle Cells ◽  
Vascular Complications ◽  
Muscle Cells ◽  
Inhibitory Effect ◽  
Diabetic Rats ◽  
High Concentration ◽  
Voltage Dependent

Vascular complications of diabetes are associated with abnormal Ca2+ handling by vascular smooth muscle cells (SMCs) in which the alteration in L-type voltage-dependent Ca2+ channel (VDCC) currents may play an important role. In the present study, the characteristics of L-type VDCC currents in tail artery SMCs from streptozotocin-induced diabetic rats were examined. The densities, but not the voltage dependence, of L-type VDCC currents were reduced as diabetes progressed from 1 wk to 3 mo. The inhibitory effect of dibutyryl-cAMP on L-type VDCC currents was greater in diabetic SMCs than in age-matched control cells ( P < 0.01). Both the stimulatory effect of BAY K 8644 and the inhibitory effect of nifedipine on L-type VDCC currents were significantly enhanced in diabetic cells. The diabetes-related abnormalities in L-type VDCC currents were mimicked by culturing SMCs with a high concentration of glucose. Our results suggest that the properties of L-type VDCC in diabetic vascular SMCs were significantly altered, partially related to the increased L-type VDCC sensitivity to cAMP and hyperglycemia.

Sign in / Sign up

Export Citation Format

Share Document