Effects of Short and Long Term Ethanol on the Activation of Signal Transducer and Activator Transcription Factor 3 in Normal and Regenerating Liver

1997 ◽  
Vol 239 (3) ◽  
pp. 666-669 ◽  
Author(s):  
Jianping Chen ◽  
Haifeng Bao ◽  
Stephen Sawyer ◽  
George Kunos ◽  
Bin Gao
Keyword(s):  
Transcription Factor ◽  
Signal Transducer ◽  
Regenerating Liver ◽  
Short And Long Term ◽  
Transcription Factor 3

Inhibition of Signal Transducer and Activator Transcription Factor 3 in Rats with Acute Hepatic Failure

2000 ◽  
Vol 273 (1) ◽  
pp. 129-135 ◽  
Author(s):  
Yukio Kamohara ◽  
Nozomu Sugiyama ◽  
Toru Mizuguchi ◽  
Daniel Inderbitzin ◽  
Helene Lilja ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Hepatic Failure ◽  
Acute Hepatic Failure ◽  
Signal Transducer ◽  
Transcription Factor 3

scholarly journals The roles of signal transducer and activator of transcription factor 3 in tumor angiogenesis

Oncotarget ◽  
2017 ◽  
Vol 8 (40) ◽  
pp. 69139-69161 ◽  
Author(s):  
Peng Gao ◽  
Na Niu ◽  
Tianshu Wei ◽  
Hideto Tozawa ◽  
Xiaocui Chen ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Tumor Angiogenesis ◽  
Signal Transducer ◽  
Transcription Factor 3

Temporal Expression of Cytokines and Signal Transducer and Activator of Transcription Factor 3 Activation after Neonatal Hypoxia/Ischemia in Mice

2013 ◽  
Vol 35 (2-3) ◽  
pp. 212-225 ◽  
Author(s):  
K. Shrivastava ◽  
G. Llovera ◽  
M. Recasens ◽  
M. Chertoff ◽  
L. Giménez-Llort ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Signal Transducer ◽  
Temporal Expression ◽  
Neonatal Hypoxia ◽  
Hypoxia Ischemia ◽  
Transcription Factor 3

scholarly journals Short- and Long-Term Adaptation to Altered Levels of Glucose: Fifty Years of Scientific Adventure

2021 ◽  
Vol 90 (1) ◽  
pp. 31-55
Author(s):  
Kosaku Uyeda
Keyword(s):  
Transcription Factor ◽  
Specific Protein ◽  
Metabolic Adaptation ◽  
Bifunctional Enzyme ◽  
Signaling Mechanism ◽  
Glucose Signaling ◽  
Postdoctoral Training ◽  
Glucose And Lipid Metabolism ◽  
Short And Long Term

My graduate and postdoctoral training in metabolism and enzymology eventually led me to study the short- and long-term regulation of glucose and lipid metabolism. In the early phase of my career, my trainees and I identified, purified, and characterized a variety of phosphofructokinase enzymes from mammalian tissues. These studies led us to discover fructose 2,6-P2, the most potent activator of phosphofructokinase and glycolysis. The discovery of fructose 2,6-P2 led to the identification and characterization of the tissue-specific bifunctional enzyme 6-phosphofructo-2-kinase:fructose 2,6-bisphosphatase. We discovered a glucose signaling mechanism by which the liver maintains glucose homeostasis by regulating the activities of this bifunctional enzyme. With a rise in glucose, a signaling metabolite, xylulose 5-phosphate, triggers rapid activation of a specific protein phosphatase (PP2ABδC), which dephosphorylates the bifunctional enzyme, thereby increasing fructose 2,6-P2 levels and upregulating glycolysis. These endeavors paved the way for us to initiate the later phase of my career in which we discovered a new transcription factor termed the carbohydrate response element binding protein (ChREBP). Now ChREBP is recognized as the masterregulator controlling conversion of excess carbohydrates to storage of fat in the liver. ChREBP functions as a central metabolic coordinator that responds to nutrients independently of insulin. The ChREBP transcription factor facilitates metabolic adaptation to excess glucose, leading to obesity and its associated diseases.

Short- and Long-Term Results of Total vs Subtotal Thyroid- ectomies in the Surgical Treatment of Graves' Disease

Swiss Surgery ◽  
2001 ◽  
Vol 7 (1) ◽  
pp. 20-24 ◽  
Author(s):  
Robert ◽  
Mariéthoz ◽  
Pache ◽  
Bertin ◽  
Caulfield ◽  
...  
Keyword(s):  
Recurrent Laryngeal Nerve ◽  
Nerve Palsy ◽  
Recurrent Laryngeal Nerve Palsy ◽  
Laryngeal Nerve ◽  
Long Term Results ◽  
Graves Disease ◽  
Laryngeal Nerve Palsy ◽  
Short And Long Term

Objective: Approximately one out of five patients with Graves' disease (GD) undergoes a thyroidectomy after a mean period of 18 months of medical treatment. This retrospective and non-randomized study from a teaching hospital compares short- and long-term results of total (TT) and subtotal thyroidectomies (ST) for this disease. Methods: From 1987 to 1997, 94 patients were operated for GD. Thirty-three patients underwent a TT (mostly since 1993) and 61 a ST (keeping 4 to 8 grams of thyroid tissue - mean 6 g). All patients had received propylthiouracil and/or neo-mercazole and were in a euthyroid state at the time of surgery; they also took potassium iodide (lugol) for ten days before surgery. Results: There were no deaths. Transient hypocalcemia (< 3 months) occurred in 32 patients (15 TT and 17 ST) and persistent hypocalcemia in 8 having had TT. Two patients developed transient recurrent laryngeal nerve palsy after ST (< 3 months). After a median follow-up period of seven years (1-15) with five patients lost to follow-up, 41 patients having had a ST are in a hypothyroid state (73%), thirteen are euthyroid (23%), and two suffered recurrent hyperthyroidism, requiring completion of thyroidectomy. All 33 patients having had TT - with follow-ups averaging two years (0.5-8) - are receiving thyroxin substitution. Conclusions: There were no instances of persistent recurrent laryngeal nerve palsy in either group, but persistent hypoparathyroidism occurred more frequently after TT. Long after ST, hypothyroidism developed in nearly three of four cases, whereas euthyroidy was maintained in only one-fourth; recurrent hyperthyroidy was rare.

Short- and long-term memory tasks predict working memory performance, and vice versa.

2019 ◽  
Vol 73 (2) ◽  
pp. 79-93 ◽  
Author(s):  
Ian Neath ◽  
Jean Saint-Aubin ◽  
Tamra J. Bireta ◽  
Andrew J. Gabel ◽  
Chelsea G. Hudson ◽  
...  
Keyword(s):  
Working Memory ◽  
Memory Performance ◽  
Long Term Memory ◽  
Term Memory ◽  
Short And Long Term
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