2,3,7,8-Tetrachlorodibenzo-p-dioxin Increases mRNA Levels for Interleukin-1β, Urokinase Plasminogen Activator, and Tumor Necrosis Factor-α in Human Uterine Endometrial Adenocarcinoma RL95-2 Cells

1997 ◽  
Vol 238 (2) ◽  
pp. 338-342 ◽  
Author(s):  
Grantley D. Charles ◽  
Kathleen T. Shiverick
Keyword(s):  
Tumor Necrosis Factor ◽  
Plasminogen Activator ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Endometrial Adenocarcinoma ◽  
Urokinase Plasminogen Activator ◽  
Interleukin 1Β ◽  
Mrna Levels ◽  
Factor Α ◽  
Necrosis Factor

scholarly journals The novel piperazino-enaminone JOAB-40 reduced colitis severity in mice via inhibition tumor necrosis factor-α and interleukin-1β

2021 ◽  
Vol 141 ◽  
pp. 111852
Author(s):  
Maitham A. Khajah ◽  
Sanaa Hawai ◽  
Doreen E. Szollosi ◽  
Ashley Bill ◽  
Ola Ghoneim ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Interleukin 1Β ◽  
The Novel ◽  
Factor Α ◽  
Necrosis Factor

Tumor Necrosis Factor-α is a Potent ACTH Secretagogue: Comparison to Interleukin-1β

Endocrinology ◽  
1989 ◽  
Vol 124 (6) ◽  
pp. 3131-3133 ◽  
Author(s):  
BURT M. SHARP ◽  
SHANNON G. MATTA ◽  
PHILLIP K. PETERSON ◽  
ROBERT NEWTON ◽  
CHUN CHAO ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Interleukin 1Β ◽  
Factor Α ◽  
Necrosis Factor

Tumor necrosis factor-α and interleukin-1β gene polymorphisms and risk of brain abscess in North Indian population

Cytokine ◽  
2015 ◽  
Vol 75 (1) ◽  
pp. 159-164 ◽  
Author(s):  
Priyanka Mishra ◽  
Kashi Nath Prasad ◽  
Kamini Singh ◽  
Anamika Bajpai ◽  
Rabi Narayan Sahu ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
Brain Abscess ◽  
Gene Polymorphisms ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Indian Population ◽  
Interleukin 1Β ◽  
North Indian Population ◽  
Factor Α ◽  
Necrosis Factor

Effect of endothelin antagonism on the production of cytokines in eosinophilic airway inflammation

2001 ◽  
Vol 280 (4) ◽  
pp. L659-L665 ◽  
Author(s):  
Finn Finsnes ◽  
Torstein Lyberg ◽  
Geir Christensen ◽  
Ole H. Skjønsberg
Keyword(s):  
Tumor Necrosis Factor ◽  
Airway Inflammation ◽  
Bronchial Asthma ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Mrna Level ◽  
Mrna Levels ◽  
Proinflammatory Mediators ◽  
Factor Α ◽  
Necrosis Factor

Endothelin (ET)-1 has been launched as an important mediator in bronchial asthma, which is an eosinophilic airway inflammation. However, the interplay between ET-1 and other proinflammatory mediators during the development of airway inflammation has not been elucidated. We wanted to study 1) whether the production of ET-1 precedes the production of other proinflammatory mediators and 2) whether ET-1 stimulates the production of these mediators within the airways. These hypotheses were studied during the development of an eosinophilic airway inflammation in rats. The increase in ET-1 mRNA level in lung tissue preceded the increase in mRNA levels of tumor necrosis factor-α, interleukin (IL)-1β, and IL-8. Treatment of the animals with the ET receptor antagonist bosentan resulted in a substantial decrease in the concentrations of tumor necrosis factor-α, IL-4, IL-1β, interferon-γ, and ET-1 in bronchoalveolar lavage fluid. In conclusion, the synthesis of ET-1 as measured by increased mRNA level precedes the synthesis of other proinflammatory cytokines of importance for the development of an eosinophilic airway inflammation, and ET antagonism inhibits the production of these mediators within the airways. Whether treatment with ET antagonists will prove beneficial for patients with eosinophilic airway inflammations like bronchial asthma is not yet known.

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