Staurosporine Induces Telophase Arrest and Apoptosis Blocking Mitosis Exit in Human Chang Liver Cells

1997 ◽  
Vol 236 (3) ◽  
pp. 594-598 ◽  
Author(s):  
Myint Swe ◽  
K.H. Sit
Keyword(s):  
Liver Cells ◽  
Chang Liver

scholarly journals Protective effect of dehydroepiandrosterone against lipid peroxidation in a human liver cell line

1999 ◽  
pp. 35-39 ◽  
Author(s):  
M Gallo ◽  
M Aragno ◽  
V Gatto ◽  
E Tamagno ◽  
E Brignardello ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Protective Effect ◽  
Human Liver ◽  
Antioxidant Properties ◽  
Liver Cells ◽  
Threshold Concentration ◽  
Blue Staining ◽  
Lag Phase ◽  
Human Liver Cell ◽  
Chang Liver

OBJECTIVE: Dehydroepiandrosterone (DHEA) is a widely studied steroid hormone with multi-functional properties. Reports suggest that some of the many activities of DHEA are due to its protective effect against lipid peroxidation. Nevertheless, the antioxidant properties of DHEA are still the subject of debate. The aim was to evaluate whether its two opposed effects on lipid peroxidation reported in the literature may be dependent on schedule and doses used. METHODS: Chang liver cells, a line derived from normal human liver, were grown in media containing either no steroids (control) or DHEA at concentrations ranging from 0.1 micromol/l to 50 micromol/l. At specific times, cultures were halted and cells received a pro-oxidant stimulus (cumene (CuOOH) 0.5 mmol/l), at which time cell viability (by trypan blue staining and lactate dehydrogenase (LDH) release) and thiobarbituric acid reactive substances (TBARS) concentration (spectrophotometrical assay) were evaluated. RESULTS: At concentrations ranging from 0.1 micromol/l to 1 micromol/l, DHEA protects Chang liver cells against lipid peroxidation and/or death induced by cumene. This effect disappears if the concentration is increased to 10 micromol/l; at higher concentrations (50 micromol/l) a pro-oxidant/cytotoxic effect of DHEA appears. CONCLUSIONS: DHEA exhibits two opposed effects on lipid peroxidation; depending on its concentration it acts either to limit or to induce oxidative stress. The threshold concentration at which the pro-oxidant activity of DHEA prevails is not far in excess of that having an antioxidant effect. Either effect of DHEA on lipid peroxidation is only evident after a 'lag-phase'.

scholarly journals The effect of paracetamol on human Chang liver cells infected by different dengue serotypes based on liver enzyme activity

2012 ◽  
Vol 16 ◽  
pp. e107
Author(s):  
H. Roslee ◽  
C. Hui Yee ◽  
S. Fakurazi ◽  
F. Azizi Jalilian ◽  
F. Othman ◽  
...  
Keyword(s):  
Enzyme Activity ◽  
Liver Enzyme ◽  
Liver Cells ◽  
Liver Enzyme Activity ◽  
Chang Liver

scholarly journals Cell Proliferation and Motility Are Inhibited by G1 Phase Arrest in 15-kDa Selenoprotein-Deficient Chang Liver Cells

2015 ◽  
Vol 38 (5) ◽  
pp. 457-465 ◽  
Author(s):  
Jeyoung Bang ◽  
Jang Hoe Huh ◽  
Ji-Woon Na ◽  
Qiao Lu ◽  
Bradley A. Carlson ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Liver Cells ◽  
G1 Phase ◽  
Phase Arrest ◽  
G1 Phase Arrest ◽  
Chang Liver

scholarly journals Anandamide-induced apoptosis in Chang liver cells involves ceramide and JNK/AP-1 pathway

2006 ◽  
Author(s):  
Michela Giuliano ◽  
Giuseppe Calvaruso ◽  
Ornella Pellerito ◽  
Patrizia Portanova ◽  
Daniela Carlisi ◽  
...  
Keyword(s):  
Liver Cells ◽  
Induced Apoptosis ◽  
Chang Liver

L-Ascorbic Acid and α-Tocopherol Reduces Hepatotoxicity Associated with Arsenic Trioxide Chemotherapy by Modulating Nrf2 and Bcl2 Transcription Factors in Chang liver Cells

2018 ◽  
Vol 70 (4) ◽  
pp. 684-696 ◽  
Author(s):  
Radhakrishnan Chandraprabha Vineetha ◽  
Viswanathan Archana ◽  
Prakash Binu ◽  
Pettamanna Arathi ◽  
Raveendran Harikumaran Nair
Keyword(s):  
Ascorbic Acid ◽  
Transcription Factors ◽  
Arsenic Trioxide ◽  
Liver Cells ◽  
Chang Liver
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