L-Type Ca2+Channel-Insulin-like Growth Factor-1 Receptor Signaling Impairment in Aging Rat Skeletal Muscle

1997 ◽  
Vol 235 (3) ◽  
pp. 784-789 ◽  
Author(s):  
M. Renganathan ◽  
W.E. Sonntag ◽  
O. Delbono
Keyword(s):  
Skeletal Muscle ◽  
Growth Factor ◽  
Insulin Like Growth Factor ◽  
Receptor Signaling ◽  
Rat Skeletal Muscle ◽  
Aging Rat

scholarly journals The effect of insulin-like growth factor II on glucose uptake and metabolism in rat skeletal muscle in vitro

1992 ◽  
Vol 286 (2) ◽  
pp. 561-565 ◽  
Author(s):  
S J Bevan ◽  
M Parry-Billings ◽  
E Opara ◽  
C T Liu ◽  
D B Dunger ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Growth Factor ◽  
Glucose Uptake ◽  
Glycogen Synthesis ◽  
Insulin Like Growth Factor ◽  
Rat Skeletal Muscle ◽  
Factor Ii ◽  
Igf Binding ◽  
Uptake And Metabolism

The effect of insulin-like growth factor II (IGF II) on the rates of lactate formation, glycogen synthesis and glucose transport in the presence of a range of concentrations of insulin were investigated using an isolated preparation of rat skeletal muscle. IGF II, at a concentration of 65 ng/ml, caused a small but significant increase in the rates of these processes at a basal physiological insulin concentration (10 muunits/ml), but was without effect in the presence of 1, 100, 1000 or 10,000 muunits of insulin/ml. Hence IGF II increased the insulin sensitivity of this tissue. This effect was removed if the incubation medium was supplemented with an equimolar concentration of IGF binding protein 1 (BP1). It is suggested that changes in the concentration of IGF II and/or BP1 may regulate glucose uptake and metabolism in skeletal muscle and have physiological significance in the control of blood glucose level.

Growth hormone regulates the level of insulin-like growth factor-I mRNA in rat skeletal muscle

1989 ◽  
Vol 120 (1) ◽  
pp. 107-112 ◽  
Author(s):  
J. Isgaard ◽  
A. Nilsson ◽  
K. Vikman ◽  
O. G. P. Isaksson
Keyword(s):  
Skeletal Muscle ◽  
Growth Factor ◽  
Rat Heart ◽  
Insulin Like Growth Factor ◽  
Rat Skeletal Muscle ◽  
Maximum Increase ◽  
Factor I ◽  
Igf I ◽  
Growth Factor I ◽  
Dose Dependent

ABSTRACT Levels of mRNA for the insulin-like growth factor-I (IGF-I) in rat heart and skeletal muscle and its dependence on GH were investigated using a solution hybridization assay. Levels of IGF-I mRNA decreased following hypophysectomy, and replacement therapy with human GH (hGH) normalized heart and skeletal muscle levels. The stimulatory effect of hGH was dose-dependent, the lowest effective dose being 100 μg. A significant increase of IGF-I mRNA was observed 60 min after s.c. administration of 100 μg hGH and the maximum increase was apparent 6–12 h after hGH injection. Administration of 200 μg IGF-I or 11 μg insulin did not significantly change levels of IGF-I mRNA. The results show that GH regulates the level of IGF-I mRNA in rat heart and skeletal muscle and give further support to the hypothesis that locally produced IGF-I might be a local mediator for the direct stimulatory effect of GH on the growth and development of heart and skeletal muscle. Journal of Endocrinology (1989) 120, 107–112

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