Flavone Acetic Acid Stimulates Nitric Oxide and Peroxynitrite Production in Subcutaneous Mouse Tumors

1997 ◽  
Vol 235 (3) ◽  
pp. 509-514 ◽  
Author(s):  
Steven R. Harris ◽  
Unnur P. Thorgeirsson
Keyword(s):  
Nitric Oxide ◽  
Acetic Acid ◽  
Flavone Acetic Acid ◽  
Mouse Tumors

Synthesis and biological study of a flavone acetic acid analogue containing an azido reporting group designed as a multifunctional binding site probe

2005 ◽  
Vol 13 (8) ◽  
pp. 2717-2722 ◽  
Author(s):  
Krishnan Malolanarasimhan ◽  
Christopher C. Lai ◽  
James A. Kelley ◽  
Lynn Iaccarino ◽  
Della Reynolds ◽  
...  
Keyword(s):  
Acetic Acid ◽  
Binding Site ◽  
Biological Study ◽  
Flavone Acetic Acid ◽  
Acid Analogue

scholarly journals Response to flavone acetic acid (NSC 347512) of primary and metastatic human colorectal carcinoma xenografts

1988 ◽  
Vol 57 (3) ◽  
pp. 277-280 ◽  
Author(s):  
R Giavazzi ◽  
A Garofalo ◽  
G Damia ◽  
S Garattini ◽  
M D'Incalci
Keyword(s):  
Acetic Acid ◽  
Colorectal Carcinoma ◽  
Flavone Acetic Acid ◽  
Human Colorectal Carcinoma

Thein vivointeraction between flavone acetic acid and hyperthermia

1996 ◽  
Vol 12 (6) ◽  
pp. 779-789 ◽  
Author(s):  
M. R. Horsman ◽  
L. E. Sampson ◽  
D. J. Chaplin ◽  
J. Overgaard
Keyword(s):  
Acetic Acid ◽  
Flavone Acetic Acid

scholarly journals AGE-RELATED CHANGES IN PROSTAGLANDIN E2, NITRIC OXIDE, AND VASCULAR ENDOTHELIAL GROWTH FACTOR LEVELS IN GASTRIC MUCOSA DURING THE HEALING OF ACETIC ACID-INDUCED ULCER

2018 ◽  
Vol 11 (10) ◽  
pp. 517
Author(s):  
Ayodeji Folorunsho Ajayi ◽  
Busuyi David Kehinde ◽  
Olubodun Micheal Lateef ◽  
Bolaji Aderibigbe Akorede
Keyword(s):  
Nitric Oxide ◽  
Vascular Endothelial Growth Factor ◽  
Acetic Acid ◽  
Growth Factor ◽  
Gastric Mucosa ◽  
Prostaglandin E2 ◽  
Ulcer Healing ◽  
Vascular Endothelial ◽  
Epithelial Restitution ◽  
Endothelial Growth Factor

Objective: Nitric oxide (NO), prostaglandin E2 (PgE2), and vascular endothelial growth factor (VEGF) are fundamental regulators of epithelial restitution and angiogenesis. They play important roles in ulcer healing. Insights into their possible changes during gastric ulcer healing putting age into consideration could give a guide to the proper management of ulcers in the aging population. This study, therefore, examined alterations in the concentrations of PgE2, NO, and VEGF in the gastric mucosa of rats of different ages after induction of ulcer and during healing.Methods: Male Wister rats (aged 3, 6, and 18 months old) were divided into three groups according to their ages. The ulcer was induced using the acetic acid ulcer model. Healing indices studied on days 3, 7, and 14 were the macroscopic dimension of ulcer, stomach tissue concentration of PgE2, NO, and VEGF, with the immunohistochemical expression of VEGF.Results: Outcome of this study showed 100%, 88.36%, and 62.30% area of mucosa healed in 3-, 6-, and 18-month-old rats respectively, on day 14 post-induction of ulcer. PgE2, NO, and VEGF concentrations were inversely proportional to age during healing. Immunohistochemical staining showed that younger rat (3 and 6 months old) had higher expression of VEGF throughout the healing period.Conclusion: It was therefore concluded that the slower rate of healing in older rats could be due to reduced gastroprotection, epithelial restitution, and angiogenesis as age increases.

(S,R)-3-Phenyl-4,5-dihydro-5-isoxazole acetic acid–Nitric Oxide (GIT-27NO) – New Dress for Nitric Oxide Mission

2010 ◽  
pp. 443-457
Author(s):  
Sanja Mijatovic ◽  
Danijela Maksimovic-Ivanic ◽  
Marco Donia ◽  
Stanislava Stosic-Grujicic ◽  
Gianni Garotta ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Acetic Acid

Flavone acetic acid (LM-975; NSC-347512) activation to cytotoxic species in vivo and in vitro

1989 ◽  
Vol 24 (5) ◽  
pp. 273-276 ◽  
Author(s):  
Guy G. Chabot ◽  
Marie-Christine Bissery ◽  
Alain Gouyette
Keyword(s):  
Acetic Acid ◽  
Flavone Acetic Acid
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