Suppression of Neutral Cholesterol Ester Hydrolase Activity by Antisense DNA of Hormone-Sensitive Lipase

1997 ◽  
Vol 233 (3) ◽  
pp. 655-657 ◽  
Author(s):  
Jun-ichi Osuga ◽  
Shun Ishibashi ◽  
Hitoshi Shimano ◽  
Toshimori Inaba ◽  
Masako Kawamura ◽  
...  
Keyword(s):  
Cholesterol Ester ◽  
Hydrolase Activity ◽  
Hormone Sensitive Lipase ◽  
Cholesterol Ester Hydrolase ◽  
Ester Hydrolase ◽  
Hormone Sensitive ◽  
Antisense Dna

scholarly journals Hormone-sensitive cholesterol ester hydrolase of bovine adrenal cortex

FEBS Letters ◽  
1981 ◽  
Vol 132 (1) ◽  
pp. 10-14 ◽  
Author(s):  
Kenneth G. Cook ◽  
Fook-Thean Lee ◽  
Stephen J. Yeaman
Keyword(s):  
Adrenal Cortex ◽  
Cholesterol Ester ◽  
Cholesterol Ester Hydrolase ◽  
Ester Hydrolase ◽  
Hormone Sensitive

Accumulated lipids, aberrant fatty acid composition and defective cholesterol ester hydrolase activity in cholesterol ester storage disease

2000 ◽  
Vol 37 (2) ◽  
pp. 187-193 ◽  
Author(s):  
Toru Todoroki ◽  
Kojiro Matsumoto ◽  
Kiyoaki Watanabe ◽  
Yukio Tashiro ◽  
Makoto Shimizu ◽  
...  
Keyword(s):  
Fatty Acid Composition ◽  
Fatty Acid ◽  
Acid Composition ◽  
Cholesterol Ester ◽  
Storage Disease ◽  
Control Level ◽  
Hydrolase Activity ◽  
Cholesterol Esters ◽  
Cholesterol Ester Hydrolase ◽  
Ester Hydrolase

We confirmed accumulation of glycogen and lipids, particularly cholesterol esters, in the liver of a patient with cholesterol ester storage disease (CESD). Hepatic cholesterol ester concentration was 100-200 times that found in normal livers. Analysis of the fatty acid composition indicated a higher proportion (41%) of cholesterol linoleate (C18-2), a slightly lower proportion (33%) of cholesterol oleate (C18-1) and normal proportions (14%) of cholesterol palmitate (C16-0) in the CESD patient compared with the control. This fatty acid composition of cholesterol esters and the fatty acid composition of other classes of lipids in the patient's liver resembled that of LDL. We also found that acid cholesterol ester hydrolase activity in the CESD liver was reduced to 5% of that in the control liver, while neutral cholesterol ester hydrolase activity remained at the control level. These results suggest that accumulated cholesterol esters were derived mainly from serum LDL and that the accumulation resulted from lack of acid cholesterol ester hydrolase.

scholarly journals Enzymatic assay for cholesterol ester hydrolase activity.

1978 ◽  
Vol 19 (7) ◽  
pp. 913-916
Author(s):  
L L Gallo ◽  
R Atasoy ◽  
G V Vahouny ◽  
C R Treadwell
Keyword(s):  
Cholesterol Ester ◽  
Enzymatic Assay ◽  
Hydrolase Activity ◽  
Cholesterol Ester Hydrolase ◽  
Ester Hydrolase
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