Reduced Connexin 43 Expression in High Grade, Human Prostatic Adenocarcinoma Cells

1996 ◽  
Vol 227 (1) ◽  
pp. 64-69 ◽  
Author(s):  
Harold Tsai ◽  
John Werber ◽  
Michael O. Davia ◽  
Morris Edelman ◽  
Kathryn E. Tanaka ◽  
...  
Keyword(s):  
Connexin 43 ◽  
Prostatic Adenocarcinoma ◽  
High Grade ◽  
Adenocarcinoma Cells

Effect of glucose and confluency on phosphorus metabolites of perfused human prostatic adenocarcinoma cells as determined by31P MRS

1993 ◽  
Vol 29 (2) ◽  
pp. 244-248 ◽  
Author(s):  
Jeffrey M. Macdonald ◽  
John Kurhanewicz ◽  
Rajvir Dahiya ◽  
Maryceline T. Espanol ◽  
Lee-Hong Chang ◽  
...  
Keyword(s):  
Prostatic Adenocarcinoma ◽  
Adenocarcinoma Cells ◽  
Phosphorus Metabolites ◽  
Effect Of Glucose

Expression of Cysteine Protease Protein 32 in Prostatic Adenocarcinoma Correlates With Tumor Grade

2004 ◽  
Vol 128 (6) ◽  
pp. 649-652
Author(s):  
Shahgul Anwar ◽  
Robert A. Ambros ◽  
Timothy A. Jennings ◽  
Jeffrey S. Ross ◽  
Anton Beza ◽  
...  
Keyword(s):  
Gleason Score ◽  
Cysteine Protease ◽  
Tumor Grade ◽  
Cysteine Proteases ◽  
Prostatic Adenocarcinoma ◽  
Gleason Grade ◽  
High Grade ◽  
Cytoplasmic Staining ◽  
Apoptosis Pathway ◽  
High Gleason Score

Abstract Context.—Controlled cell death is mediated by apoptosis-specific genes, tumor suppressor genes, and oncogenes. The caspase family is a group of at least 15 known cysteine proteases that serve as initiator and effector molecules of the apoptosis pathway. On activation, caspases cause cell shrinkage, condensation of chromatin, fragmentation of DNA, and the formation of blebs in the cytoplasmic membrane. Objectives.—The patterns of cysteine protease protein (CCP) 32 (caspase-3) expression have been determined in normal human tissues and a variety of tumors, and have been shown to correlate with the outcome in breast cancer and linked to resistance to chemotherapy in other tumors. This study was performed to determine whether CPP32 is expressed in prostatic adenocarcinoma and to define its relationship with outcome variables. Design.—Formalin-fixed, paraffin-embedded radical prostatectomy specimens from 211 patients with prostatic adenocarcinoma were evaluated for CPP32 expression by immunohistochemistry. Hematoxylin-eosin–stained slides were reviewed, and tumors were graded based on the Gleason grading system. Tumors were scored for CPP32 expression semiquantitatively, based on the staining intensity and distribution patterns. These results were compared with Gleason grade and clinical and pathologic stages. Results.—One hundred thirty-three (63%) of 211 cases showed high expression of CPP32, whereas expression was low in 78 (37%) cases. One hundred three (49%) of 211 cases had a high Gleason score (7 and above). Of 103 cases with a high Gleason score, 74 (72%) showed high CPP32 expression. Strong cytoplasmic staining for CPP32 in high-grade tumors was statistically significant (P = .01). Also, by linear regression analysis a significant correlation was seen between the Gleason score and the cytoplasmic CPP32 expression (P = .001). Expression of CPP32 did not correlate with either clinical stage (P = .28) or pathologic stage (P = .60); however, this study included very few patients with stage IV disease. Conclusion.—The correlation between CPP32 and high tumor grade suggests a CPP32-related high turnover rate in high-grade prostatic adenocarcinoma. Moreover, strong correlation with Gleason grade, a powerful predictor of disease progression and overall survival, suggests potential usefulness of CPP32 as a prognostic factor, especially in limited biopsy samples.

scholarly journals High grade foamy gland prostatic adenocarcinoma, a rare pathological variant treated with radical prostatectomy

2020 ◽  
Vol 38 (2) ◽  
pp. 80
Author(s):  
Malhasi Gunawardena ◽  
Umesh Jayarajah ◽  
Susantha De Silva ◽  
Serozsha Goonewardena ◽  
Chandu De Silva
Keyword(s):  
Radical Prostatectomy ◽  
Prostatic Adenocarcinoma ◽  
High Grade ◽  
Pathological Variant

Effect of thermal variables on frozen human primary prostatic adenocarcinoma cells

Urology ◽  
1996 ◽  
Vol 48 (3) ◽  
pp. 441-447 ◽  
Author(s):  
Kristine Tatsutani ◽  
Boris Rubinsky ◽  
Gary Onik ◽  
Rajvir Dahiya
Keyword(s):  
Prostatic Adenocarcinoma ◽  
Adenocarcinoma Cells

scholarly journals Immunophenotype of High-Grade Prostatic Adenocarcinoma and Urothelial Carcinoma

2000 ◽  
Vol 13 (11) ◽  
pp. 1186-1191 ◽  
Author(s):  
Elizabeth M Genega ◽  
Brian Hutchinson ◽  
Victor E Reuter ◽  
Paul B Gaudin
Keyword(s):  
Urothelial Carcinoma ◽  
Prostatic Adenocarcinoma ◽  
High Grade

scholarly journals ERG and PTEN status of isolated high-grade PIN occurring in cystoprostatectomy specimens without invasive prostatic adenocarcinoma

2016 ◽  
Vol 55 ◽  
pp. 117-125 ◽  
Author(s):  
Carlos L. Morais ◽  
Liana B. Guedes ◽  
Jessica Hicks ◽  
Alexander S. Baras ◽  
Angelo M. De Marzo ◽  
...  
Keyword(s):  
Prostatic Adenocarcinoma ◽  
High Grade

Abstract 4518: Prevalence of high-grade prostatic adenocarcinoma in a black African population

2018 ◽  
Author(s):  
Emeka F. Nnakenyi ◽  
Ifeyinwa D. Nnakenyi ◽  
Okechukwu C. Okafor ◽  
Fred O. Ugwumba
Keyword(s):  
Prostatic Adenocarcinoma ◽  
African Population ◽  
High Grade ◽  
Black African
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