scholarly journals Heterogeneity of the HumanSecretorα(1,2)Fucosyltransferase Gene among Lewis(a+b−) Non-secretors

1996 ◽  
Vol 222 (2) ◽  
pp. 390-394 ◽  
Author(s):  
Lung-Chih Yu ◽  
Richard E. Broadberry ◽  
Yun-Hsin Yang ◽  
Yee-Hsiung Chen ◽  
Marie Lin
1995 ◽  
Vol 312 (2) ◽  
pp. 329-332 ◽  
Author(s):  
L C Yu ◽  
Y H Yang ◽  
R E Broadberry ◽  
Y H Chen ◽  
Y S Chan ◽  
...  

A missense mutation (A385 to T), predicting an Ile129 to Phe substitution, in the human Secretor alpha 1,2-fucosyltransferase gene was present in double dose in Lewis(a+b+) individuals, but not in Lewis(a-b+) individuals. Co-segregation of the Lewis(a+b+) phenotype with homozygosity for the mutation was also verified. These results yield a potential molecular basis for the weak Secretor allele (Sew) accounting for the Lewis(a+b+) phenotype.


Glycobiology ◽  
2002 ◽  
Vol 12 (5) ◽  
pp. 299-306 ◽  
Author(s):  
R. Leonard ◽  
G. Costa ◽  
E. Darrambide ◽  
S. Lhernould ◽  
P. Fleurat-Lessard ◽  
...  

1994 ◽  
Vol 269 (3) ◽  
pp. 1595-1598
Author(s):  
C.T. Yuen ◽  
K. Bezouska ◽  
J. O'Brien ◽  
M. Stoll ◽  
R. Lemoine ◽  
...  
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