Glutamic Acid 141 of the Diphtheria Toxin Receptor (HB-EGF Precursor) Is Critical for Toxin Binding and Toxin Sensitivity

1996 ◽  
Vol 220 (3) ◽  
pp. 675-680 ◽  
Author(s):  
Kyle P. Hooper ◽  
Leon Eidels
Keyword(s):  
Glutamic Acid ◽  
Diphtheria Toxin ◽  
Toxin Binding ◽  
Diphtheria Toxin Receptor ◽  
Toxin Receptor ◽  
Toxin Sensitivity

scholarly journals Structure-Function Analysis of the Diphtheria Toxin Receptor Toxin Binding Site by Site-directed Mutagenesis

1997 ◽  
Vol 272 (43) ◽  
pp. 27084-27090 ◽  
Author(s):  
Toshihide Mitamura ◽  
Toshiyuki Umata ◽  
Fumie Nakano ◽  
Yuji Shishido ◽  
Tetsuro Toyoda ◽  
...  
Keyword(s):  
Structure Function ◽  
Binding Site ◽  
Diphtheria Toxin ◽  
Function Analysis ◽  
Site Directed Mutagenesis ◽  
Directed Mutagenesis ◽  
Toxin Binding ◽  
Diphtheria Toxin Receptor ◽  
Toxin Receptor

scholarly journals CD206+ macrophage is an accelerator of endometriotic-like lesion via promoting angiogenesis in the endometriosis mouse model

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Yosuke Ono ◽  
Osamu Yoshino ◽  
Takehiro Hiraoka ◽  
Erina Sato ◽  
Akiko Furue ◽  
...  
Keyword(s):  
Mouse Model ◽  
Diphtheria Toxin ◽  
Immunohistochemical Study ◽  
Mrna Levels ◽  
Cytokines And Chemokines ◽  
Diphtheria Toxin Receptor ◽  
Endothelial Cell Marker ◽  
Toxin Receptor ◽  
Group A

AbstractIn endometriosis, M2 MΦs are dominant in endometriotic lesions, but the actual role of M2 MΦ is unclear. CD206 positive (+) MΦ is classified in one of M2 type MΦs and are known to produce cytokines and chemokines. In the present study, we used CD206 diphtheria toxin receptor mice, which enable to deplete CD206+ cells with diphtheria toxin (DT) in an endometriosis mouse model. The depletion of CD206+ MΦ decreased the total weight of endometriotic-like lesions significantly (p < 0.05). In the endometriotic-like lesions in the DT group, a lower proliferation of endometriotic cells and the decrease of angiogenesis were observed. In the lesions, the mRNA levels of VEGFA and TGFβ1, angiogenic factors, in the DT group significantly decreased to approximately 50% and 30% of control, respectively. Immunohistochemical study revealed the expressions of VEGFA and an endothelial cell marker CD31 in lesions of the DT group, were dim compared to those in control. Also, the number of TGFβ1 expressing MΦ was significantly reduced compared to control. These data suggest that CD206+ MΦ promotes the formation of endometriotic-like lesions by inducing angiogenesis around the lesions.

Expression cloning of a diphtheria toxin receptor: Identity with a heparin-binding EGF-like growth factor precursor

Cell ◽  
1992 ◽  
Vol 69 (6) ◽  
pp. 1051-1061 ◽  
Author(s):  
Joseph G. Naglich ◽  
James E. Metherall ◽  
David W. Russell ◽  
Leon Eidels
Keyword(s):  
Growth Factor ◽  
Diphtheria Toxin ◽  
Expression Cloning ◽  
Heparin Binding ◽  
Diphtheria Toxin Receptor ◽  
Toxin Receptor
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