Efficient Regulation of Gene Expression by Adenovirus Vector-Mediated Delivery of the CRE Recombinase

1995 ◽  
Vol 217 (2) ◽  
pp. 393-401 ◽  
Author(s):  
K. Sakai ◽  
K. Mitani ◽  
J. Miyazaki
Keyword(s):  
Gene Expression ◽  
Regulation Of Gene Expression ◽  
Adenovirus Vector ◽  
Cre Recombinase

scholarly journals Dual regulation of gene expression mediated by tetracycline and Cre recombinase

BioTechniques ◽  
2004 ◽  
Vol 36 (3) ◽  
pp. 390-396 ◽  
Author(s):  
Jae Yoon Park ◽  
Qing Luo ◽  
Wei Jiang ◽  
Quan Kang ◽  
Ying Peng ◽  
...  
Keyword(s):  
Gene Expression ◽  
Regulation Of Gene Expression ◽  
Cre Recombinase

Linking transcription, RNA polymerase II elongation and alternative splicing

2020 ◽  
Vol 477 (16) ◽  
pp. 3091-3104 ◽  
Author(s):  
Luciana E. Giono ◽  
Alberto R. Kornblihtt
Keyword(s):  
Gene Expression ◽  
Alternative Splicing ◽  
Rna Polymerase Ii ◽  
Environmental Changes ◽  
Transcription Elongation ◽  
Single Gene ◽  
Regulation Of Gene Expression ◽  
Regulation Of Transcription ◽  
Stepping Stones ◽  
Eukaryotic Transcription

Gene expression is an intricately regulated process that is at the basis of cell differentiation, the maintenance of cell identity and the cellular responses to environmental changes. Alternative splicing, the process by which multiple functionally distinct transcripts are generated from a single gene, is one of the main mechanisms that contribute to expand the coding capacity of genomes and help explain the level of complexity achieved by higher organisms. Eukaryotic transcription is subject to multiple layers of regulation both intrinsic — such as promoter structure — and dynamic, allowing the cell to respond to internal and external signals. Similarly, alternative splicing choices are affected by all of these aspects, mainly through the regulation of transcription elongation, making it a regulatory knob on a par with the regulation of gene expression levels. This review aims to recapitulate some of the history and stepping-stones that led to the paradigms held today about transcription and splicing regulation, with major focus on transcription elongation and its effect on alternative splicing.

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