Orally Active and Long-Term Acting Insulin-Mimetic Vanadyl Complex: Bis(Picolinato)oxovanadium(IV)

1995 ◽  
Vol 214 (3) ◽  
pp. 1095-1101 ◽  
Author(s):  
H. Sakurai ◽  
K. Fujii ◽  
H. Watanabe ◽  
H. Tamura
Keyword(s):  
Insulin Mimetic ◽  
Vanadyl Complex ◽  
Acting Insulin ◽  
Orally Active

A New Type of Orally Active Insulin-Mimetic Vanadyl Complex: Bis(1-oxy-2-pyridinethiolato)oxovanadium(IV) with VO(S2O2) Coordination Mode

1999 ◽  
Vol 28 (9) ◽  
pp. 913-914 ◽  
Author(s):  
Hiromu Sakurai ◽  
Hiromi Sano ◽  
Toshikazu Takino ◽  
Hiroyuki Yasui
Keyword(s):  
Coordination Mode ◽  
Insulin Mimetic ◽  
Vanadyl Complex ◽  
New Type ◽  
Orally Active

A new orally active insulin-mimetic vanadyl complex: bis(pyrrolidine-N-carbodithioato)oxovanadium(IV)

1994 ◽  
Vol 37 (7) ◽  
pp. 876-877 ◽  
Author(s):  
Hiromi Watanabe ◽  
Masami Nakai ◽  
Kyoko Komazawa ◽  
Hiromu Sakurai
Keyword(s):  
Insulin Mimetic ◽  
Vanadyl Complex ◽  
Orally Active

scholarly journals Long-Term Acting and Orally Active Vanadyl-Methylpicolinate Complex with Hypoglycemic Activity in Streptozotocin-Induced Diabetic Rats.

1997 ◽  
Vol 23 (2) ◽  
pp. 113-129 ◽  
Author(s):  
Seiki FUJIMOTO ◽  
Kumiko FUJII ◽  
Hiroyuki YASUI ◽  
Rokuji MATSUSHITA ◽  
Jitsuya TAKADA ◽  
...  
Keyword(s):  
Diabetic Rats ◽  
Hypoglycemic Activity ◽  
Orally Active

Validated HPLC Method for Quantification of a Novel Trk Inhibitor, Larotrectinib in Mice Plasma: Application to a Pharmacokinetic Study

Drug Research ◽  
2020 ◽  
Vol 70 (02/03) ◽  
pp. 101-106
Author(s):  
Harsha K. Tripathy ◽  
S.V. Nair Manju ◽  
Ashok Zakkula ◽  
Ram Murthi Bestha ◽  
Sreekanth Dittakavi ◽  
...  
Keyword(s):  
Pharmacokinetic Study ◽  
High Performance ◽  
Wave Length ◽  
Internal Standard ◽  
Hplc Method ◽  
Long Term Storage ◽  
Development And Validation ◽  
Orally Active ◽  
Regulatory Guideline

AbstractLarotrectinib, is an orally active novel small molecule approved for the treatment of solid tumors in pediatrics and adult patients. It acts by inhibiting tropomyosin receptor kinase. In this paper, we report the development and validation of a high-performance liquid chromatography (HPLC) method for the quantitation of larotrectinib in mice plasma as per the FDA regulatory guideline. Plasma samples processing was accomplished through simple protein precipitation using acetonitrile enriched with internal standard (IS, enasidenib). The chromatographic analysis was performed using a gradient mobile phase comprising 10 mM ammonium acetate and acetonitrile at a flow-rate of 0.8 mL/min on an X-Terra Phenyl column. The UV detection wave length was set at λmax 262 nm. Larotrectinib and the IS eluted at 3.85 and 6.60 min, respectively with a total run time of 8.0 min. The calibration curve was linear over a concentration range of 0.20–5.00 μg/mL (r2=≥0.992). The intra- and inter-day precision and accuracy results were within the acceptable limits. Results of stability studies indicated that larotrectinib was stable on bench-top, in auto-sampler, up to three freeze/thaw cycles and long-term storage at −80°C. The validated HPLC method was successfully applied to a pharmacokinetic study in mice.

New long-term action insulin formulations obtained using polycations for heparin neutralization

2019 ◽  
Vol 15 (3) ◽  
Author(s):  
Kamil Kamiński ◽  
Marta Kaczor-Kamińska ◽  
Izabela Irska ◽  
Iwona Popiołek ◽  
Krzysztof Szczubiałka ◽  
...  
Keyword(s):  
Light Scattering ◽  
Dynamic Light Scattering ◽  
Anticoagulant Activity ◽  
Fluorescence Measurements ◽  
Charged Polymers ◽  
Acting Insulin ◽  
Long Acting ◽  
Heparin Neutralization ◽  
Positively Charged

AbstractPhenomena that occur between an insulin and four different positively charged polymers (protamine, cationic dextran, chitosan, and poliallylamine derivatives) were studied by dynamic light scattering and fluorescence measurements (using fluorescein-labeled polymers). These processes were compared to the reaction of polycations with heparin that is responsible for the neutralization of anticoagulant activity in blood stream.The nature of polycations interaction with heparin is electrostatic, while the interaction with insulin is more complicated.We observed that the presence of zinc atoms (and its complexing by nitrogen from macromolecules) is critical for insulin suspensions formation and stability. The differences between the nature of these two reactions were revealed. The highly immunogenic action of protamine present in long-acting insulin products makes it reasonable to develop similar systems based on the nonprotein polycations.

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