Genetic Variability in the TNF-α Promoter Is Not Associated with Type II Diabetes Mellitus (NIDDM)

1995 ◽  
Vol 211 (3) ◽  
pp. 833-839 ◽  
Author(s):  
A. Hamann ◽  
C. Mantzoros ◽  
A. Vidalpuig ◽  
J.S. Flier
Keyword(s):  
Diabetes Mellitus ◽  
Genetic Variability ◽  
Type Ii Diabetes ◽  
Type Ii Diabetes Mellitus ◽  
Type Ii ◽  
Tnf Α

scholarly journals Genetic variability of the SUR1 promoter in relation to beta-cell function and Type II diabetes mellitus

Diabetologia ◽  
2001 ◽  
Vol 44 (10) ◽  
pp. 1330-1334 ◽  
Author(s):  
T. Hansen ◽  
L. Ambye ◽  
N. Grarup ◽  
L. Hansen ◽  
S. M. Echwald ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Genetic Variability ◽  
Beta Cell ◽  
Type Ii Diabetes ◽  
Beta Cell Function ◽  
Cell Function ◽  
Type Ii Diabetes Mellitus ◽  
Type Ii

TNF-α pathway and T-cell immunity are activated early during the development of diabetic nephropathy in Type II Diabetes Mellitus

2020 ◽  
Vol 215 ◽  
pp. 108423
Author(s):  
Ioanna Theologia Lampropoulou ◽  
Μaria Stangou ◽  
Pantelis Sarafidis ◽  
Antigoni Gouliovaki ◽  
Panagiotis Giamalis ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Diabetic Nephropathy ◽  
T Cell ◽  
Type Ii Diabetes ◽  
Type Ii Diabetes Mellitus ◽  
T Cell Immunity ◽  
Type Ii ◽  
Cell Immunity ◽  
Tnf Α

scholarly journals Alstonia boonei Leaf Mitigated Deleterious Effects of Experimental Type-II-Diabetes-Mellitus against Pancreatic and Neurocognitive Functions

2021 ◽  
pp. 19-35
Author(s):  
Violet Olubunmi Falusi ◽  
Sunday Oluwayomi ◽  
Bamidele Imoukhuede ◽  
Gideon Oludare Oladipo
Keyword(s):  
Diabetes Mellitus ◽  
Type Ii Diabetes ◽  
Type Ii Diabetes Mellitus ◽  
Type Ii ◽  
Inflammatory Stress ◽  
Neurocognitive Functions ◽  
Tnf Α ◽  
Experimental Type ◽  
Biochemical Analyses ◽  
Neurocognitive Decline

The search for prompt, less toxic and economically affordable medical therapy has facilitated the increased investigation into the therapeutic potentials and applications of plants samples against common tropical ailments. This study was designed to investigate the reported link between experimental type II diabetes mellitus (T2DM) and neurocognitive decline and the justification for the use Alstonia boonei leaf in similar treatments. Experimental T2DM were treated with 100, 1000 and 1600 mg/kg BWT of the Alstonia boonei leaf and glibenclamide (100 mg/kg BWT). Biochemical analyses were used to determine effects on the pancreatic and neuronal indices of tissues functions; oxidative stress; excitation; and inflammation; blood glucose and insulin concentrations. The study revealed that T2DM and Alstonia boonei leaf affected the activity of tyrosine hydroxylase which is the regulating enzyme for the biosynthesis of dopamine. The oxidative and inflammatory stress exacerbated by T2DM was mitigated by a significant reduction of TNF-α and an increase of GSH, NP-SH, GPx, SOD and GST levels. Alstonia boonei leaf reversed the insulin resistance by the cells, with effective transduction of insulin signal and a corresponding reduction of circulating glucose. Alstonia boonei leaf demonstrated hypoglycaemic effect, and mitigated the neurodegeneration that ensued from the diabetic induction.

ANTIHYPERGLYCEMIC EFFECTS OF THE NORTHERN BERRY EXTRACTS IN THE STREPTOZOTOCIN-INDUCED RAT MODEL OF TYPE II DIABETES MELLITUS

2020 ◽  
Vol 17 (3) ◽  
pp. 193-205
Author(s):  
E.А. Krivykh ◽  
◽  
А.E. Gulyaev ◽  
L.V. Kovalenko ◽  
Z.T. Shulgau ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Resistance ◽  
Gallic Acid ◽  
Type Ii Diabetes ◽  
Type Ii Diabetes Mellitus ◽  
Pancreatic Tissue ◽  
Type Ii ◽  
Tnf Α ◽  
Berry Extracts ◽  
Water Alcohol

The purpose of this study was to study the potential therapeutic properties of water-alcohol extracts of bilberry, blueberries, cowberries, cranberries, on the model of experimental streptozotocin diabetes mellitus. Research material and methods. Wild bilberry, cowberries, cranberries and blueberries collected in the summer and autumn of 2018 in the Surgut district of the Khanty-Mansiysk district of the Tyumen region of the Russian Federation were used to obtain polyphenolic water-alcohol extracts of Northern berries. The extracts were concentrated in a vacuum evaporator to the level of polyphenols in 10 mg / ml. the Rats were injected with polyphenol extracts at the rate of 10 mg / kg (the input volume of 0.2-0.3 ml). Results. The concentration of polyphenols in the samples was studied using a commercial set for determining the concentration of polyphenols «Polyphenols folin-ciocalteu (ENOLOGY line by BioSytems. Spain)», in accordance with the instructions of the reagent manufacturer. The results were expressed in the equivalent of Gallic acid, i.e. mg of Gallic acid/ml of berry extract (mgGAE /ml Conclusion. A model of type II diabetes mellitus obtained in rats with streptozotocin was used to study the effect of extracts of wild bilberry, cowberries, cranberries and blueberries in North-Western Siberia on the level of glycemia and insulin resistance, lipid metabolism, the level of expression of CRP, IL-6 and TNF-α in the liver and adipose tissue of rats, and histopathological changes in pancreatic tissue were also established. Determined that extracts of bilberry, cowberries, cranberries and blueberry on the model of diabetes reduces the severity of insulin resistance such as Metformin, lower blood glucose levels (except lingonberry extract), reduce the concentration of triglycerides (except cowberries extract), reduces the concentration of LDL (except cranberries and cowberries). The use of blueberry extract on the background of diabetes reduces the expression of inflammatory cytokine genes IL-6, TNF-α and CRP. At the same time, extracts of Northern berries in the blood plasma prevent excessive release of free radicals and increase antioxidant activity. Pathomorphological studies of pancreatic tissue document a lower degree of damage to the Langerhans islets against the background of the introduction of Northern berry extracts.

scholarly journals Nitric Oxide Mediates Inflammation in Type II Diabetes Mellitus through the PPARγ/eNOS Signaling Pathway

PPAR Research ◽  
2020 ◽  
Vol 2020 ◽  
pp. 1-7
Author(s):  
Hua Guo ◽  
Qinglan Zhang ◽  
Haipo Yuan ◽  
Lin Zhou ◽  
Fang-fang Li ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Diabetes Mellitus ◽  
Hepg2 Cells ◽  
Type Ii Diabetes ◽  
Type Ii Diabetes Mellitus ◽  
Type Ii ◽  
C Reactive Protein ◽  
No Donor ◽  
Reactive Protein ◽  
Tnf Α

Inflammation accounts for the process of type II diabetes mellitus (T2DM), the specific mechanism of which is still to be elucidated yet. Nitric oxide (NO), a critical inflammation regulator, the role of which is the inflammation of T2DM, is rarely reported. Therefore, our study is aimed at exploring the effect of NO on the inflammation in T2DM and the corresponding mechanism. We analyzed the NO levels in plasma samples from T2DM patients and paired healthy adults by Nitric Oxide Analyzer then measured the expression of inflammatory cytokines (C-reactive protein, heptoglobin, IL-1β, TNF-α, IL-6) in insulin-induced HepG2 cells treated with NO donor or NO scavenger, and the PPARγ, eNOS, C-reactive protein, heptoglobin, IL-1β, TNF-α, and IL-6 levels were detected by RT-PCR and western blot in insulin-induced HepG2 cells transfected with si-PPARγ. The results showed that excess NO increased the inflammation marker levels in T2DM, which is activated by the PPARγ/eNOS pathway. These findings will strengthen the understanding of NO in T2DM and provide a new target for the treatment of T2DM.

scholarly journals Estimation of Plasma Levels of Tumor Necrosis Factor-α, Interleukin-4 and 6 in Patients with Chronic Periodontitis and Type II Diabetes Mellitus

2018 ◽  
Vol 19 (2) ◽  
pp. 166-169 ◽  
Author(s):  
Jasjit Sahota ◽  
Dipanshu Bakshi ◽  
Guneet Kaur ◽  
Deepinder Singh ◽  
Ambika Thakur ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Tumor Necrosis Factor ◽  
Chronic Periodontitis ◽  
Type Ii Diabetes ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Type Ii Diabetes Mellitus ◽  
Type Ii ◽  
Tnf Α ◽  
Factor Α

ABSTRACT Introduction Both periodontitis and type II diabetes mellitus (T2DM) are common diseases with a multifactorial etiology and have influence of cytokines in their pathogenesis and thus may also influence each other. In recent times, more attention has been given to understanding the influences of these inflammatory cytokines which are a main part of oral chronic inflammation on systemic health of the individuals. Therefore, the aim of this study was to evaluate the plasma cytokine levels, specifically tumor necrosis factor-α (TNF-α), interleukin (IL)-6, and IL-4, in chronic periodontitis patients and T2DM patients, so as to investigate the influence of chronic periodontitis in systemic inflammation associated with diabetes mellitus. Materials and methods The present study comprised a total sample size of 60 patients. A detailed history along with complete periodontal examination were done for each person. These patients were subdivided into four study groups with 15 subjects (n = 15) in each group: group I: healthy individuals, group II: chronic periodontitis, group III: diabetes mellitus without chronic periodontitis, and group IV: diabetes mellitus with chronic periodontitis. Venous blood was withdrawn for obtaining serum samples from the subjects. Hemoglobin A1c (HbA1c) levels were measured from the automated chromatography. Using enzyme-linked immunosorbent assay kit, TNF-α, IL-4, and IL-6 were measured. Results It was observed that the difference between almost all the results showed statistical significance. Not much of a difference was seen when TNF-α and IL-6 findings of group II were compared with group III. Furthermore, IL-4 also did not differ when group II was compared with group IV. Conclusion The inflammatory cytokines together control the inflammation process and a balance is maintained. However, in patients with diabetes mellitus, this balance is interrupted, which affects the final development and progression of the disease. Thus, hyperglycemia may be partly associated with the severity of the periodontal status in diabetic patients. Clinical significance Hyperglycemia thus may play a role in increasing the severity of the periodontal status in diabetic patients. Keeping such relationship in mind, better treatment modalities can be provided to the patients. How to cite this article Bakshi D, Kaur G, Singh D, Sahota J, Thakur A, Grover S. Estimation of Plasma Levels of Tumor Necrosis Factor-α, Interleukin-4 and 6 in Patients with Chronic Periodontitis and Type II Diabetes Mellitus. J Contemp Dent Pract 2018;19(2):166-169.

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