Human T Helper Cell Epitopes Overlap B Cell and Putative Cytotoxic T Cell Epitopes in the E2 Protein of Human Papillomavirus Type 16

1995 ◽  
Vol 209 (2) ◽  
pp. 541-546 ◽  
Author(s):  
M. Lehtinen ◽  
M.H. Hibma ◽  
G. Stellato ◽  
T. Kuoppala ◽  
J. Paavonen
Keyword(s):  
Human Papillomavirus ◽  
T Cell ◽  
B Cell ◽  
T Helper Cell ◽  
Helper Cell ◽  
Cytotoxic T Cell ◽  
T Cell Epitopes ◽  
T Helper ◽  
E2 Protein ◽  
Human Papillomavirus Type 16

Fewer protective cytotoxic T-cell epitopes than T-helper-cell epitopes on vesicular stomatitis virus.

1993 ◽  
Vol 67 (6) ◽  
pp. 3680-3683 ◽  
Author(s):  
T M Kündig ◽  
I Castelmur ◽  
M F Bachmann ◽  
D Abraham ◽  
D Binder ◽  
...  
Keyword(s):  
T Cell ◽  
Vesicular Stomatitis Virus ◽  
T Helper Cell ◽  
Helper Cell ◽  
Cytotoxic T Cell ◽  
T Cell Epitopes ◽  
T Helper ◽  
Vesicular Stomatitis

A T-helper cell epitope overlaps a major B-cell epitope in human papillomavirus type 18 E2 protein

Apmis ◽  
1992 ◽  
Vol 100 (7-12) ◽  
pp. 1022-1026 ◽  
Author(s):  
MATTI LEHTINEN ◽  
GIOVANNI STELLATO ◽  
HEIKKI HYÖTY ◽  
PEKKA NIEMINEN ◽  
ERVO VESTERINEN ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
B Cell ◽  
Cell Epitope ◽  
T Helper Cell ◽  
Helper Cell ◽  
T Helper ◽  
E2 Protein ◽  
B Cell Epitope

scholarly journals Identification and characterization of enhancer agonist human cytotoxic T-cell epitopes of the human papillomavirus type 16 (HPV16) E6/E7

Vaccine ◽  
2017 ◽  
Vol 35 (19) ◽  
pp. 2605-2611 ◽  
Author(s):  
Kwong Y. Tsang ◽  
Massimo Fantini ◽  
Romaine I. Fernando ◽  
Claudia Palena ◽  
Justin M. David ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
T Cell ◽  
Cytotoxic T Cell ◽  
T Cell Epitopes ◽  
Hpv16 E6 ◽  
Human Papillomavirus Type 16 ◽  
Identification And Characterization

scholarly journals Differential macrophage requirements for T helper cell and T helper cell-induced B lymphocyte proliferation.

1983 ◽  
Vol 157 (1) ◽  
pp. 312-323 ◽  
Author(s):  
A Bandeira ◽  
G Pobor ◽  
S Petterson ◽  
A Coutinho
Keyword(s):  
T Cell ◽  
B Cell ◽  
B Lymphocyte ◽  
T Helper Cell ◽  
Helper Cell ◽  
T Helper ◽  
Helper T Cell ◽  
Cell Responses ◽  
Macrophage Depletion ◽  
B Cell Responses

Major histocompatibility complex-restricted helper T cell clones against "minor" antigens expressed on B cell and macrophage surfaces, when confronted with appropriate T cell-depleted spleen cells, are induced to proliferation and, in turn, activate "target-responder" B cells to polyclonal growth and maturation. Irradiation of helper cell populations, however, demonstrates that their effector functions (and B lymphocyte responses) are independent of proliferative activity. Adherent cell depletion on Sephadex G10 columns, while completely abrogating helper T cell proliferation, does not abolish helper cell-induced B cell responses, demonstrating a remarkable quantitative difference in macrophage requirements for the growth of these two cell types. Because significant B cell responses are detected upon interaction with primed helper T cells under conditions of extreme macrophage depletion, we conclude that the role of macrophages in T-B cell cooperation is limited to expansion of optimal numbers of helper T lymphocytes. It follows that activated helper cells can autonomously produce all B cell-specific growth and maturation factors mediating cooperative antibody responses. In contrast, the profound reduction of LPS-induced responses upon macrophage depletion suggests accessory cell production of such factors in thymus-independent B cell growth and/or maturation.

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