Existence of an Enzymatic Pathway Furnishing Arachidonic Acid for Prostaglandin Synthesis from Arachidonoyl CoA in Rabbit Kidney Medulla

1994 ◽  
Vol 202 (2) ◽  
pp. 1054-1059 ◽  
Author(s):  
S. Sakuma ◽  
Y. Fujimoto ◽  
K. Doi ◽  
S. Nagamatsu ◽  
H. Nishida ◽  
...  
Keyword(s):  
Arachidonic Acid ◽  
Prostaglandin Synthesis ◽  
Rabbit Kidney ◽  
Kidney Medulla

scholarly journals The interaction between lipid peroxidation and prostaglandin synthesis in rabbit kidney-medulla slices

1983 ◽  
Vol 212 (1) ◽  
pp. 167-171 ◽  
Author(s):  
Y Fujimoto ◽  
H Tanioka ◽  
I Keshi ◽  
T Fujita
Keyword(s):  
Lipid Peroxidation ◽  
Ascorbic Acid ◽  
Arachidonic Acid ◽  
Prostaglandin E2 ◽  
Inhibitory Effect ◽  
Prostaglandin Synthesis ◽  
Rabbit Kidney ◽  
Kidney Medulla ◽  
Prostaglandin Endoperoxide Synthase ◽  
Generating System

Lipid peroxidation induced by ascorbic acid and Fe2+ was inhibited by mepacrine (phospholipase A2 inhibitor) and aspirin (prostaglandin cyclo-oxygenase inhibitor) in rabbit kidney-medulla slices. Moreover, ascorbic acid and Fe2+ potentiated the inhibitory effect on prostaglandin E2 formation by mepacrine, but they had no influence on prostaglandin E2 production decreased by aspirin. Lipid peroxidation induced by ascorbic acid and Fe2+ appears to be affecting the activity of prostaglandin endoperoxide synthase. These results suggest that lipid peroxidation is connected closely with the prostaglandin-generating system, and it has the potential to modulate the turnover of arachidonic acid and prostaglandin synthesis.

Existence of acyl-CoA hydrolase-mediated pathway supplying arachidonic acid for prostaglandin synthesis in microsomes from rabbit kidney medulla

1999 ◽  
Vol 57 (2-3) ◽  
pp. 63-72 ◽  
Author(s):  
Satoru Sakuma ◽  
Yohko Fujimoto ◽  
Takashi Sawada ◽  
Kazuki Saeki ◽  
Manabu Akimoto ◽  
...  
Keyword(s):  
Arachidonic Acid ◽  
Prostaglandin Synthesis ◽  
Rabbit Kidney ◽  
Kidney Medulla ◽  
Coa Hydrolase

Comparison of the effects of Fe2+ and Cu2+ on prostaglandin synthesis in rabbit kidney medulla slices

1987 ◽  
Vol 39 (3) ◽  
pp. 230-233 ◽  
Author(s):  
Tadashi Fujita ◽  
Noboru Ohtani ◽  
Midori Aihara ◽  
Kazuyuki Nishioka ◽  
Yohko Fujimoto
Keyword(s):  
Prostaglandin Synthesis ◽  
Rabbit Kidney ◽  
Kidney Medulla
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