Atrial Natriuretic Peptide Inhibits Endothelin-1-Induced Activation of Mitogen-Activated Protein Kinase in Cultured Rat Mesangial Cells

1993 ◽  
Vol 195 (1) ◽  
pp. 72-78 ◽  
Author(s):  
T. Sugimoto ◽  
R. Kikkawa ◽  
M. Haneda ◽  
Y. Shigeta
Keyword(s):  
Protein Kinase ◽  
Atrial Natriuretic Peptide ◽  
Natriuretic Peptide ◽  
Mesangial Cells ◽  
Mitogen Activated Protein Kinase ◽  
Endothelin 1 ◽  
Mitogen Activated Protein ◽  
Atrial Natriuretic

scholarly journals Atrial Natriuretic Peptide Inhibits Mitogen-activated Protein Kinase through the Clearance Receptor

1996 ◽  
Vol 271 (24) ◽  
pp. 14156-14162 ◽  
Author(s):  
Bruce A. Prins ◽  
Michael J. Weber ◽  
Ren-Ming Hu ◽  
Ali Pedram ◽  
Mark Daniels ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Atrial Natriuretic Peptide ◽  
Natriuretic Peptide ◽  
Mitogen Activated Protein Kinase ◽  
Mitogen Activated Protein ◽  
Clearance Receptor ◽  
Atrial Natriuretic

Phosphorylation of the precursor sequence of rat B-type natriuretic peptide by p34cdc2 and MAP kinase

1994 ◽  
Vol 72 (5-6) ◽  
pp. 227-232 ◽  
Author(s):  
Vasek A. Mezl ◽  
Mark H. Watson ◽  
T. Geoffrey Flynn ◽  
Alan S. Mak
Keyword(s):  
Protein Kinase ◽  
Atrial Natriuretic Peptide ◽  
Natriuretic Peptide ◽  
Leader Sequence ◽  
Mitogen Activated Protein Kinase ◽  
Phosphorylation Sites ◽  
Sea Star ◽  
Mitogen Activated Protein ◽  
Atrial Natriuretic

Atrial natriuretic peptide (ANP) and B-type natriuretic peptide (BNP), two distinct members of the natriuretic peptide family, share many features in common. However, differences in expression indicate that the processing mechanisms must be different. The leader sequence of rat BNP contains three potential phosphorylation sites for proline-directed kinases that are not present in the leader sequence of ANP. This study has examined how these sites are used by two somewhat different proline-directed kinases. A peptide containing these sites was phosphorylated in vitro by HeLa p34cdc2 kinase and by sea star p44mpk kinase at rates that were comparable to the rates with peptide substrates that are used to assay these enzymes. Sequence analysis of the phosphopeptide shows that both kinases phosphorylate only the two potential phosphorylation sites surrounding the cleavage site of the BNP precursor. The enzymatic potential for such a phosphorylation of BNP in cardiac tissue is demonstrated by immunoblots and kinase assays, showing that in fetal and in adult rat heart both the atria and the ventricles contain a mitogen-activated protein kinase homologue that can phosphorylate this preproBNP sequence.Key words: atrial natriuretic peptide, cdc2 kinase, mitogen-activated protein kinase, phosphorylation.

Effect of endothelin-1(1-31) on p38 mitogen-activated protein kinase in cultured human mesangial cells

Life Sciences ◽  
2000 ◽  
Vol 68 (6) ◽  
pp. 635-645 ◽  
Author(s):  
Daisuke Inui ◽  
Masanori Yoshizumi ◽  
Yuki Suzaki ◽  
Kazuyoshi Kirima ◽  
Koichiro Tsuchiya ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Mesangial Cells ◽  
Mitogen Activated Protein Kinase ◽  
Human Mesangial Cells ◽  
Endothelin 1 ◽  
Mitogen Activated Protein

scholarly journals Endothelin-1 (1-31) activates p38 Mitogen-Activated Protein Kinase in Human Mesangial Cells

2000 ◽  
Vol 82 ◽  
pp. 124
Author(s):  
Yuki Suzaki ◽  
Daisuke Inui ◽  
Kazuyoshi Kirima ◽  
Yuichi Ozawa ◽  
Koichiro Tsuchiya ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Mesangial Cells ◽  
Mitogen Activated Protein Kinase ◽  
Human Mesangial Cells ◽  
Endothelin 1 ◽  
Mitogen Activated Protein

scholarly journals Atrial natriuretic peptide inhibits endothelin-1-induced activation of JNK in glomerular mesangial cells

1998 ◽  
Vol 53 (5) ◽  
pp. 1133-1142 ◽  
Author(s):  
Motohide Isono ◽  
Masakazu Haneda ◽  
Shiro Maeda ◽  
Mariko Omatsu-Kanbe ◽  
Ryuichi Kikkawa
Keyword(s):  
Atrial Natriuretic Peptide ◽  
Natriuretic Peptide ◽  
Mesangial Cells ◽  
Glomerular Mesangial Cells ◽  
Endothelin 1 ◽  
Atrial Natriuretic

scholarly journals Endothelin-1-specific Activation of B-type Natriuretic Peptide Gene via p38 Mitogen-activated Protein Kinase and Nuclear ETS Factors

2002 ◽  
Vol 278 (6) ◽  
pp. 3969-3975 ◽  
Author(s):  
Sampsa Pikkarainen ◽  
Heikki Tokola ◽  
Risto Kerkelä ◽  
Theresa Majalahti-Palviainen ◽  
Olli Vuolteenaho ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Natriuretic Peptide ◽  
Mitogen Activated Protein Kinase ◽  
Endothelin 1 ◽  
Mitogen Activated Protein ◽  
Peptide Gene ◽  
Ets Factors
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