Does Intraduodenal Administration of Sucrose Polyester (Olestra) Cause Satiation in Humans?

Appetite ◽  
1999 ◽  
Vol 33 (2) ◽  
pp. 195-208 ◽  
Author(s):  
M.I.M. MAAS ◽  
W.P.M. HOPMAN ◽  
B.VAN GELDER ◽  
M. JACOBS ◽  
A.F.J. DE HAAN ◽  
...  
Keyword(s):  
Sucrose Polyester ◽  
Intraduodenal Administration

scholarly journals Unhydrolyzed Vegetable Sucrose Polyester in Broiler Diets

2001 ◽  
Vol 80 (10) ◽  
pp. 1506-1508 ◽  
Author(s):  
B.L. Damron ◽  
S.K. Williams ◽  
A.R. Eldred
Keyword(s):  
Sucrose Polyester

Sucrose polyester and covert caloric dilution

1982 ◽  
Vol 35 (6) ◽  
pp. 1352-1359 ◽  
Author(s):  
C J Glueck ◽  
M M Hastings ◽  
C Allen ◽  
E Hogg ◽  
L Baehler ◽  
...  
Keyword(s):  
Sucrose Polyester

The substitution of sucrose polyester for dietary fat in obese, hypercholesterolemic outpatients

1985 ◽  
Vol 41 (1) ◽  
pp. 1-12 ◽  
Author(s):  
M J Mellies ◽  
C Vitale ◽  
R J Jandacek ◽  
G E Lamkin ◽  
C J Glueck
Keyword(s):  
Dietary Fat ◽  
Sucrose Polyester

scholarly journals The endocrine effects of bitter tastant administration in the gastrointestinal system - Intragastric versus intraduodenal administration

2021 ◽  
Author(s):  
Wout Verbeure ◽  
Eveline Deloose ◽  
Joran Tóth ◽  
Jens F. Rehfeld ◽  
Lukas Van Oudenhove ◽  
...  
Keyword(s):  
Feeding Tube ◽  
Gut Peptides ◽  
Nasogastric Feeding ◽  
Physiological Relevance ◽  
Quinine Hydrochloride ◽  
Healthy Female ◽  
Glucagon Like Peptide ◽  
Glucagon Like Peptide 1 ◽  
Acyl Ghrelin ◽  
Intraduodenal Administration

Bitter tastants are recently introduced as potential hunger-suppressive compounds, the so-called "Bitter pill". However, the literature about bitter administration lacks consistency in methods and findings. We want to test whether hunger ratings and hormone plasma levels are affected by: 1) the site of administration: intragastrically (IG) or intraduodenally (ID), 2) the bitter tastant itself, quinine hydrochloride (QHCl) or denatonium benzoate (DB), and 3) the timing of infusion. Therefore, 14 healthy, female volunteers participated in a randomized, placebo-controlled six-visit crossover study. After an overnight fast, DB (1µmol/kg), QHCl (10µmol/kg) or placebo were given IG or ID via a nasogastric feeding tube. Blood samples were taken 10 min prior to administration and every 10 min after administration for a period of 2 hours. Hunger was rated at the same timepoints on a visual analogue scale (VAS). ID bitter administration did not affect hunger sensations, motilin or acyl-ghrelin release compared with its PLC infusion. IG QHCl infusion tended to suppress hunger increase, especially between 50-70 minutes after infusion, simultaneously with reduced motilin values. Here, acyl-ghrelin was not affected. IG DB did not affect hunger or motilin, however acyl-ghrelin levels were reduced 50-70 minutes after infusion. Plasma values of glucagon-like peptide 1 and cholecystokinin were too low to be properly detected or to have any physiological relevance. In conclusion, bitter tastants should be infused into the stomach to reduce hunger sensations and orexigenic gut peptides. QHCl has the best potential to reduce hunger sensations, and it should be infused 60 minutes before food intake.

Optimization of Sucrose Polyester Synthesis Using Response Surface Methodology

1996 ◽  
Vol 61 (1) ◽  
pp. 97-100 ◽  
Author(s):  
CHWEN-JEN SHIEH ◽  
PHILIP E. KOEHLER ◽  
CASIMIR C. AKOH
Keyword(s):  
Response Surface Methodology ◽  
Response Surface ◽  
Sucrose Polyester

scholarly journals Sucrose polyester in human volunteers

1999 ◽  
Vol 81 (2) ◽  
pp. 169-170 ◽  
Author(s):  
Nora Zorich ◽  
Greg Allgood ◽  
John Peters
Keyword(s):  
Sucrose Polyester ◽  
Human Volunteers
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