Kinetics of Methionine Transport and Metabolism by Trypanosoma brucei brucei and Trypanosoma brucei rhodesiense

2000 ◽  
Vol 377 (1) ◽  
pp. 49-57 ◽  
Author(s):  
Burt Goldberg ◽  
Donna Rattendi ◽  
David Lloyd ◽  
Nigel Yarlett ◽  
Cyrus J. Bacchi
Keyword(s):  
Trypanosoma Brucei ◽  
Trypanosoma Brucei Rhodesiense ◽  
Trypanosoma Brucei Brucei ◽  
Kinetics Of ◽  
Methionine Transport

Activity of Extracts and Naphthoquinones from Kigelia pinnata Against Trypanosoma brucei brucei and Trypanosoma brucei rhodesiense

Planta Medica ◽  
1999 ◽  
Vol 65 (6) ◽  
pp. 536-540 ◽  
Author(s):  
S. V.K. Moideen ◽  
P. J. Houghton ◽  
P. Rock ◽  
S. L. Croft ◽  
F. Aboagye-Nyame
Keyword(s):  
Trypanosoma Brucei ◽  
Trypanosoma Brucei Rhodesiense ◽  
Trypanosoma Brucei Brucei ◽  
Kigelia Pinnata

scholarly journals Trypanocidal Activity of 8-Methyl-5′-{[(Z)-4-Aminobut-2-enyl]-(Methylamino)}Adenosine (Genz-644131), an Adenosylmethionine Decarboxylase Inhibitor

2009 ◽  
Vol 53 (8) ◽  
pp. 3269-3272 ◽  
Author(s):  
Cyrus J. Bacchi ◽  
Robert H. Barker ◽  
Aixa Rodriguez ◽  
Bradford Hirth ◽  
Donna Rattendi ◽  
...  
Keyword(s):  
Trypanosoma Brucei ◽  
Dose Range ◽  
System Model ◽  
Drug Resistant ◽  
Trypanosoma Brucei Rhodesiense ◽  
Trypanosoma Brucei Brucei ◽  
African Trypanosomes ◽  
Adenosylmethionine Decarboxylase ◽  
Daily Dose ◽  
Purine Ring

ABSTRACT Genzyme 644131, 8-methyl-5′-{[(Z)-4-aminobut-2-enyl](methylamino)}adenosine, is an analog of the enzyme activated S-adenosylmethionine decarboxylase (AdoMetDC) inhibitor and the trypanocidal agent MDL-7381, 5-{[(Z)-4-aminobut-2-enyl](methylamino)}adenosine. The analog differs from the parent in having an 8-methyl group on the purine ring that bestows favorable pharmacokinetic, biochemical, and trypanocidal activities. The compound was curative in acute Trypanosoma brucei brucei and drug-resistant Trypanosoma brucei rhodesiense model infections, with single-dose activity in the 1- to 5-mg/kg/day daily dose range for 4 days against T. brucei brucei and 25- to 50-mg/kg twice-daily dosing against T. brucei rhodesiense infections. The compound was not curative in the TREU 667 central nervous system model infection but cleared blood parasitemia and extended time to recrudescence in several groups. This study shows that AdoMetDC remains an attractive chemotherapeutic target in African trypanosomes and that chemical changes in AdoMetDC inhibitors can produce more favorable drug characteristics than the lead compound.

scholarly journals De Novo Genome Assembly Shows Genome Wide Similarity between Trypanosoma brucei brucei and Trypanosoma brucei rhodesiense

PLoS ONE ◽  
2016 ◽  
Vol 11 (2) ◽  
pp. e0147660 ◽  
Author(s):  
Mark Sistrom ◽  
Benjamin Evans ◽  
Joshua Benoit ◽  
Oliver Balmer ◽  
Serap Aksoy ◽  
...  
Keyword(s):  
Trypanosoma Brucei ◽  
Genome Assembly ◽  
De Novo ◽  
Trypanosoma Brucei Rhodesiense ◽  
Trypanosoma Brucei Brucei ◽  
De Novo Genome Assembly ◽  
Genome Wide

scholarly journals C-Terminal Mutants of Apolipoprotein L-I Efficiently Kill Both Trypanosoma brucei brucei and Trypanosoma brucei rhodesiense

2009 ◽  
Vol 5 (12) ◽  
pp. e1000685 ◽  
Author(s):  
Laurence Lecordier ◽  
Benoit Vanhollebeke ◽  
Philippe Poelvoorde ◽  
Patricia Tebabi ◽  
Françoise Paturiaux-Hanocq ◽  
...  
Keyword(s):  
Trypanosoma Brucei ◽  
Trypanosoma Brucei Rhodesiense ◽  
Trypanosoma Brucei Brucei
Sign in / Sign up

Export Citation Format

Share Document