Human Betaine–Homocysteine Methyltransferase Is a Zinc Metalloenzyme

1998 ◽  
Vol 356 (1) ◽  
pp. 93-98 ◽  
Author(s):  
Norman S. Millian ◽  
Timothy A. Garrow
Keyword(s):  
Betaine Homocysteine Methyltransferase ◽  
Homocysteine Methyltransferase

Betaine: a key modulator of one-carbon metabolism and homocysteine status

2005 ◽  
Vol 43 (10) ◽  
Author(s):  
Per Magne Ueland ◽  
Pål I. Holm ◽  
Steinar Hustad
Keyword(s):  
Carbon Metabolism ◽  
Individual Variability ◽  
Vitamin B ◽  
Total Homocysteine ◽  
Altered Metabolism ◽  
One Carbon Metabolism ◽  
And Gender ◽  
Betaine Homocysteine Methyltransferase ◽  
Plasma Total Homocysteine ◽  
Homocysteine Methyltransferase

AbstractBetaine serves as a methyl donor in a reaction converting homocysteine to methionine, catalysed by the enzyme betaine-homocysteine methyltransferase. It has been used for years to lower the concentration of plasma total homocysteine (tHcy) in patients with homocystinuria, and has recently been shown to reduce fasting and in particular post-methionine load (PML) tHcy in healthy subjects.Betaine exists in plasma at concentrations of about 30μmol/L; it varies 10-fold (from 9 to 90μmol/L) between individuals, but the intra-individual variability is small. Major determinants are choline, dimethylglycine and folate in plasma, folic acid intake and gender.Recent studies have demonstrated that plasma betaine is a stronger determinant of PML tHcy than are vitamin BTo conclude, betaine status is a component of an individual's biochemical make-up with ramifications to one-carbon metabolism. Betaine status should be investigated in pathologies related to altered metabolism of homocysteine and folate, including cardiovascular disease, cancer and neural tube defects.

Betaine homocysteine methyltransferase (BHMT) as a specific and sensitive blood marker for acute liver injury

Biomarkers ◽  
2014 ◽  
Vol 19 (7) ◽  
pp. 578-584 ◽  
Author(s):  
Huailei Ma ◽  
Jing Ning ◽  
Xin Jin ◽  
Chunming Mao ◽  
Xiangli Bu ◽  
...  
Keyword(s):  
Liver Injury ◽  
Acute Liver Injury ◽  
Blood Marker ◽  
Betaine Homocysteine Methyltransferase ◽  
Homocysteine Methyltransferase

scholarly journals Molecular characterization and analysis of the porcine betaine homocysteine methyltransferase and betaine homocysteine methyltransferase-2 genes

Gene ◽  
2011 ◽  
Vol 473 (2) ◽  
pp. 133-138 ◽  
Author(s):  
Radhika S. Ganu ◽  
Timothy A. Garrow ◽  
Monika Sodhi ◽  
Laurie A. Rund ◽  
Lawrence B. Schook
Keyword(s):  
Molecular Characterization ◽  
Betaine Homocysteine Methyltransferase ◽  
Homocysteine Methyltransferase

Both the folate cycle and betaine‐homocysteine methyltransferase contribute methyl groups for DNA methylation in mouse blastocysts

2014 ◽  
Vol 29 (3) ◽  
pp. 1069-1079 ◽  
Author(s):  
Baohua Zhang ◽  
Michelle M. Denomme ◽  
Carlee R. White ◽  
Kit‐Yi Leung ◽  
Martin B. Lee ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Methyl Groups ◽  
Betaine Homocysteine Methyltransferase ◽  
Folate Cycle ◽  
Homocysteine Methyltransferase

scholarly journals Betaine-homocysteine Methyltransferase Is a Developmentally Regulated Enzyme Crystallin in Rhesus Monkey Lens

1998 ◽  
Vol 273 (46) ◽  
pp. 30669-30674 ◽  
Author(s):  
P. Vasantha Rao ◽  
Timothy A. Garrow ◽  
Faith John ◽  
Donita Garland ◽  
Norman S. Millian ◽  
...  
Keyword(s):  
Rhesus Monkey ◽  
Developmentally Regulated ◽  
Betaine Homocysteine Methyltransferase ◽  
Homocysteine Methyltransferase
Sign in / Sign up

Export Citation Format

Share Document