scholarly journals Calcium Indirectly Increases the Control Exerted by the Adenine Nucleotide Translocator over 2-Oxoglutarate Oxidation in Rat Heart Mitochondria

1995 ◽  
Vol 324 (1) ◽  
pp. 130-134 ◽  
Author(s):  
Vida Mildaziene ◽  
Rasa Baniene ◽  
Zita Nauciene ◽  
Barbara M. Bakker ◽  
Guy C. Brown ◽  
...  
Keyword(s):  
Rat Heart ◽  
Adenine Nucleotide ◽  
Heart Mitochondria ◽  
Adenine Nucleotide Translocator ◽  
Rat Heart Mitochondria

scholarly journals Effect of aging and acetyl-l -carnitine on the activity of cytochrome oxidase and adenine nucleotide translocase in rat heart mitochondria

FEBS Letters ◽  
1994 ◽  
Vol 350 (2-3) ◽  
pp. 213-215 ◽  
Author(s):  
Giuseppe Paradies ◽  
Francesca Maria Ruggiero ◽  
Giuseppe Petrosillo ◽  
Maria Nicola Gadaleta ◽  
Ernesto Quagliariello
Keyword(s):  
Cytochrome Oxidase ◽  
Rat Heart ◽  
Adenine Nucleotide ◽  
Adenine Nucleotide Translocase ◽  
Heart Mitochondria ◽  
Rat Heart Mitochondria

scholarly journals Astaxanthin Prevents Mitochondrial Impairment Induced by Isoproterenol in Isolated Rat Heart Mitochondria

Antioxidants ◽  
2020 ◽  
Vol 9 (3) ◽  
pp. 262 ◽  
Author(s):  
Olga Krestinina ◽  
Yulia Baburina ◽  
Roman Krestinin ◽  
Irina Odinokova ◽  
Irina Fadeeva ◽  
...  
Keyword(s):  
Mitochondrial Dysfunction ◽  
Rat Heart ◽  
Adenine Nucleotide ◽  
Heart Function ◽  
Isolated Rat Heart ◽  
Heart Mitochondria ◽  
Cyclophilin D ◽  
Inner Mitochondrial Membrane ◽  
Respiratory Chain Complexes ◽  
Rat Heart Mitochondria

Mitochondria are considered to be a power station of the cell. It is known that they play a major role in both normal and pathological heart function. Alterations in mitochondrial bioenergetics are one of the main causes of the origin and progression of heart failure since they have an inhibitory effect on the activity of respiratory complexes in the inner mitochondrial membrane. Astaxanthin (AST) is a xanthophyll carotenoid of mainly marine origin. It has both lipophilic and hydrophilic properties and may prevent mitochondrial dysfunction by permeating the cell membrane and co-localizing within mitochondria. The carotenoid suppresses oxidative stress-induced mitochondrial dysfunction and the development of diseases. In the present study, it was found that the preliminary oral administration of AST upregulated the activity of respiratory chain complexes and ATP synthase and the level of their main subunits, thereby improving the respiration of rat heart mitochondria (RHM) in the heart injured by isoproterenol (ISO). AST decreased the level of cyclophilin D (CyP-D) and increased the level of adenine nucleotide translocase (ANT) in this condition. It was concluded that AST could be considered as a potential mitochondrial-targeted agent in the therapy of pathological conditions associated with oxidative damage and mitochondrial dysfunction. AST, as a dietary supplement, has a potential in the prevention of cardiovascular diseases.

Magnolol and honokiol isolated from magnolia officinalis protect rat heart mitochondria against lipid peroxidation

1994 ◽  
Vol 47 (3) ◽  
pp. 549-553 ◽  
Author(s):  
Yu-Chiang Lo ◽  
Teng Che-Ming ◽  
Chen Chieh-Fu ◽  
Chen Chien-Chih ◽  
Hong Chuang-Ye
Keyword(s):  
Lipid Peroxidation ◽  
Rat Heart ◽  
Heart Mitochondria ◽  
Rat Heart Mitochondria ◽  
Magnolia Officinalis
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