Effect of dietary calcium and phosphorus vitamin D metabolites 25(OH)D and 1,25(OH)2D, and response to bPTH (1-34) in blue duikers

Zoo Biology ◽  
2002 ◽  
Vol 21 (2) ◽  
pp. 171-183 ◽  
Author(s):  
Beverly L. Roeder ◽  
Gabriella A. Varga ◽  
Robert F. Wideman ◽  
Bruce W. Hollis
Keyword(s):  
Vitamin D ◽  
Dietary Calcium ◽  
Vitamin D Metabolites ◽  
Calcium And Phosphorus

Effects of Dietary Calcium and Phosphorus on Vitamin D Metabolism and Calcium Absorption in Hamster

1996 ◽  
Vol 211 (3) ◽  
pp. 281-286 ◽  
Author(s):  
H. P. Schedl ◽  
T. Conway ◽  
R. L. Horst ◽  
D. L. Miller ◽  
C. K. Brown
Keyword(s):  
Vitamin D ◽  
Calcium Absorption ◽  
Dietary Calcium ◽  
Vitamin D Metabolism ◽  
Calcium And Phosphorus

Vitamin D Metabolites and Parathyroid Hormone in Cushing’s Syndrome: Relationship to Calcium and Phosphorus Homeostasis*

1982 ◽  
Vol 54 (5) ◽  
pp. 1039-1044 ◽  
Author(s):  
JAMES W. FINDLING ◽  
NANCY D. ADAMS ◽  
JACOB LEMANN ◽  
RICHARD W. GRAY ◽  
CAROL J. THOMAS ◽  
...  
Keyword(s):  
Vitamin D ◽  
Parathyroid Hormone ◽  
Cushing’S Syndrome ◽  
Cushing's Syndrome ◽  
Vitamin D Metabolites ◽  
Calcium And Phosphorus

scholarly journals Vitamin D Metabolism Alteration in Acromegaly and Its Impact on Calcium-Phosphorus Metabolism

2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. A651-A652
Author(s):  
Alexandra Povaliaeva ◽  
Liudmila Rozhinskaya ◽  
ScD, Artem Zhukov ◽  
Ekaterina A Pigarova ◽  
ScD, Larisa K Dzeranova ◽  
...  
Keyword(s):  
Vitamin D ◽  
Biochemical Parameters ◽  
Control Group ◽  
Vitamin D Metabolites ◽  
Phosphorus Metabolism ◽  
Total Calcium ◽  
Healthy Individuals ◽  
Hydroxylase Activity ◽  
Calcium Phosphorus ◽  
Calcium And Phosphorus

Abstract Objective: to evaluate metabolism of vitamin D and calcium-phosphorus metabolism in patients with an active phase of acromegaly in comparison with healthy individuals. Materials and Methods: The study included 44 patients with an active acromegaly (IGF-1 788 [521; 963] ng/mL), as well as 49 conditionally healthy individuals. There were more men in the Acromegaly group (41% vs. 20%, p <0.05), patients were older (median age 42.7 [35.5; 26.5] vs. 26.3 [25; 33.5] years, p <0.05) and had a higher BMI (28.4 [25.2; 30.2] vs. 22.2 [20.1; 26.1] kg/m2, p <0.05) in a minor way compared with the control group. All participants were tested for vitamin D metabolites (25(OH)D3, 25(OH)D2, 1,25(OH)2D3, 3-epi-25(OH)D3 and 24,25(OH)2D3) by UPLC-MS/MS, free 25(OH)D and vitamin D-binding protein by ELISA, PTH by electrochemiluminescence immunoassay, as well as routine biochemical parameters of blood serum (calcium, phosphorus, creatinine, albumin, magnesium) and urine (calcium and phosphorus-creatinine ratio in spot urine). Results: In the Acromegaly group, we observed significantly higher levels of serum total calcium (2.46 [2.37; 2.56] vs. 2.38 [2.33; 2.45] mmol/L, p <0.05), albumin-corrected calcium (2.33 [2.28; 2.42] vs. 2.26 [2.21; 2.31] mmol/L, p <0.05) and phosphorus (1.39 [1.25; 1.55] vs. 1.15 [1.06; 1.23] mmol/L, p <0.05) as well as lower levels of serum albumin (45 [44; 47] vs. 46 [45; 48] g/L, p <0.05). The rest of the studied biochemical parameters and PTH levels did not differ significantly between the groups. The IGF-1 level in patients with acromegaly positively correlated with the level of total calcium (r = 0.49, p <0.05), albumin-corrected calcium (r = 0.49, p <0.05) and phosphorus (r = 0.55, p <0.05). The Acromegaly group showed lower levels of 25(OH)D3 (14.8 [11.8; 20.5] vs. 20.5 [14.8; 24.6] ng/mL, p <0.05), 3-epi-25(OH)D3 (1.0 [0.7; 1.4] vs. 1.4 [0.9; 1.8] ng/mL, p <0.05), 24,25(OH)2D3 (0.8 [0.4; 1.2] vs. 1.7 [0.9; 2.6] ng/ml, p <0.05) and free 25(OH)D (4.6 [3.7; 5.6] vs. 5.9 [4.0; 7.5] pg/mL, p <0.05), higher levels of 1,25(OH)2D3 (50 [42; 63] vs. 39 [34; 45] pg/mL, p <0.05), a lower 25(OH)D3/1,25(OH)2D3 ratio (289 [226; 443] vs. 517 [340; 641], p <0.05) and a higher 25(OH)D3/24,25(OH)2D3 ratio (19.3 [15.4; 27.7] vs. 11.9 [9.6; 15.2], p <0.05). Conclusion: Our data suggest that high levels of the active vitamin D metabolite (1,25(OH)2D3) resulting from an increase in 1α-hydroxylase activity may contribute to the elevation of calcium and phosphorus serum levels in patients with acromegaly. Our results also indicate a decrease in 24-hydroxylase activity in patients with acromegaly, which may be due to lower levels of 25(OH)D3 in these patients. The results obtained should be evaluated taking into account the observed differences in age, gender and BMI between groups.

scholarly journals Impact of Increasing Dietary Calcium Levels on Calcium Excretion and Vitamin D Metabolites in the Blood of Healthy Adult Cats

PLoS ONE ◽  
2016 ◽  
Vol 11 (2) ◽  
pp. e0149190 ◽  
Author(s):  
Nadine Paßlack ◽  
Bettina Schmiedchen ◽  
Jens Raila ◽  
Florian J. Schweigert ◽  
Friederike Stumpff ◽  
...  
Keyword(s):  
Vitamin D ◽  
Healthy Adult ◽  
Dietary Calcium ◽  
Calcium Excretion ◽  
Vitamin D Metabolites ◽  
Adult Cats
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