Synthesis, Structure, and Fluorescent Properties of Lanthanide Complexes Based on 8-Hydroxyquinoline-7-carboxylic Acid

2016 ◽  
Vol 642 (5) ◽  
pp. 372-376 ◽  
Author(s):  
Changyan Sun ◽  
Peiying Zhao ◽  
Meiju Wei ◽  
Zhidong Chang ◽  
Wenjun Li
Keyword(s):  
Carboxylic Acid ◽  
Lanthanide Complexes ◽  
Fluorescent Properties

scholarly journals New Samarium(III), Gadolinium(III), and Dysprosium(III) Complexes of Coumarin-3-Carboxylic Acid as Antiproliferative Agents

2007 ◽  
Vol 2007 ◽  
pp. 1-8 ◽  
Author(s):  
Irena Kostova ◽  
Georgi Momekov ◽  
Peya Stancheva
Keyword(s):  
Carboxylic Acid ◽  
Antiproliferative Activity ◽  
Myeloid Leukemia ◽  
Lanthanide Complexes ◽  
Binding Mode ◽  
Bidentate Coordination ◽  
Metal Nitrates ◽  
Samarium Complex ◽  
Physicochemical Data ◽  
Ir And Raman

New complexes of samarium(III), gadolinium(III), and dysprosium(III) with coumarin-3-carboxylic acid (HCCA) were prepared by the reaction of the ligand with respective metal nitrates in ethanol. The structures of the final complexes were determined by means of physicochemical data, elemental analysis, IR and Raman spectra. The metal-ligand binding mode in the new Ln(III) complexes of coumarin-3-carboxylic acid was elucidated. The vibrational study gave evidence for bidentate coordination of CCA− to Ln(III) ions through the carbonylic oxygen and the carboxylic oxygen atoms. The complexes were tested for antiproliferative activitiy on the chronic myeloid leukemia-derived K-562, overexpressing the BCR-ABL fusion protein. Cytotoxicity towards tumor cells was determined for a broad concentration range. The samarium salt exerted a very weak antiproliferative effect on these cells. This is in contrast to the lanthanide complexes, especially samarium complex, which exhibited potent antiproliferative activity. The present study confirms our previous observations that the lanthanide complexes of coumarins exhibit antiproliferative activity towards K-562 cell line.

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