scholarly journals Diagnostic accuracy of serum pepsinogens for atrophic gastritis in Myanmar

GastroHep ◽  
2021 ◽  
Author(s):  
Myint N. Tun ◽  
Khin S. Aye ◽  
Than T. Aye
Keyword(s):  
Diagnostic Accuracy ◽  
Atrophic Gastritis ◽  
Serum Pepsinogens

Correlation of serum pepsinogens and gastrin-17 with atrophic gastritis in gastroesophageal reflux patients: A matched-pairs study

2010 ◽  
Vol 26 (1) ◽  
pp. 82-89 ◽  
Author(s):  
Ulrich Peitz ◽  
Thomas Wex ◽  
Michael Vieth ◽  
Manfred Stolte ◽  
Stefan Willich ◽  
...  
Keyword(s):  
Gastroesophageal Reflux ◽  
Atrophic Gastritis ◽  
Matched Pairs ◽  
Serum Pepsinogens

scholarly journals An international survey on recognition and characterization of atrophic gastritis and intestinal metaplasia

2020 ◽  
Vol 08 (10) ◽  
pp. E1365-E1370
Author(s):  
Hon Chi Yip ◽  
Noriya Uedo ◽  
Shannon M. Chan ◽  
Anthony Yuen Bun Teoh ◽  
Simon Kin Hung Wong ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Diagnostic Accuracy ◽  
Atrophic Gastritis ◽  
Intestinal Metaplasia ◽  
Classification Systems ◽  
International Survey ◽  
Screening And Surveillance ◽  
The World ◽  
The Difference

Abstract Background and study aims Atrophic gastritis (AG) and intestinal metaplasia (IM) are premalignant conditions of gastric cancer and endoscopic recognition and characterization may help in stratifying the gastric cancer risk for screening and surveillance. However, there is currently lack of consensus in defining the severity of AG and IM. We aimed to conduct an international survey to understand the current practice of endoscopists worldwide. Methods An online survey was designed to collect data regarding participants’ practice in endoscopic assessment of AG & IM. A test using images was conducted to evaluate the difference in accuracy of characterization of AG & IM. Results From July to October 2017, 249 endoscopists responded to the survey. Around 70 % of participants received some form of training on recognition of AG & IM. There was significant variety in the training received across different continents. One hundred seventy-six participants (70 %) would document the presence of both AG and IM, but the classification systems used were inconsistent between endoscopists. Overall accuracy in diagnosis of AG & IM in the image test was 84.5 % and 80.7 % respectively. The diagnostic accuracy was significantly higher among Japanese and Korean endoscopists compared to the rest of the world. Conclusion Training regarding endoscopic recognition of AG & IM differs significantly in different parts of the world. The difference in diagnostic accuracy for these premalignant gastric conditions may also explain the discrepancy in the early cancer detection rates among different countries. A simple unified classification system may be beneficial for better stratification of cancer risks.

Serum Pepsinogens as a Predicator of the Topography of Intestinal Metaplasia in Patients with Atrophic Gastritis

2004 ◽  
Vol 49 (5) ◽  
pp. 795-801 ◽  
Author(s):  
Yoshihisa Urita ◽  
Kazuo Hike ◽  
Naotaka Torii ◽  
Yoshinori Kikuchi ◽  
Eiko Kanda ◽  
...  
Keyword(s):  
Atrophic Gastritis ◽  
Intestinal Metaplasia ◽  
Serum Pepsinogens

scholarly journals Usefulness of Serum Pepsinogens to Identify Chronic Atrophic Gastritis

2011 ◽  
Vol 140 (5) ◽  
pp. S-318
Author(s):  
Francesco Di Mario ◽  
Massimo Rugge ◽  
Giulia M. Cavestro ◽  
Carmelo Scarpignato ◽  
Patrizia Perazzo ◽  
...  
Keyword(s):  
Atrophic Gastritis ◽  
Chronic Atrophic Gastritis ◽  
Serum Pepsinogens

M1141 Diagnostic Accuracy of Serum Pepsinogens and Gastrin to Follow-up Helicobacter pylori Infection: A Pilot Study

2010 ◽  
Vol 138 (5) ◽  
pp. S-340
Author(s):  
Luigi Gatta ◽  
Francesco Di Mario ◽  
Dino Vaira ◽  
Massimo Rugge ◽  
Carmelo Scarpignato ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Pilot Study ◽  
Diagnostic Accuracy ◽  
Helicobacter Pylori Infection ◽  
Serum Pepsinogens

scholarly journals DIAGNOSTIC ACCURACY OF GASTROPANEL® FOR ATROPHIC GASTRITIS IN BRAZILIAN SUBJECTS AND THE EFFECT OF PROTON PUMP INHIBITORS

2020 ◽  
Vol 57 (2) ◽  
pp. 154-160
Author(s):  
Rejane MATTAR ◽  
Sergio Barbosa MARQUES ◽  
Igor Braga RIBEIRO ◽  
Thiago Arantes de Carvalho VISCONTI ◽  
Mateus FUNARI ◽  
...  
Keyword(s):  
Diagnostic Accuracy ◽  
Atrophic Gastritis ◽  
Likelihood Ratio ◽  
Proton Pump Inhibitors ◽  
Proton Pump ◽  
Positive Likelihood Ratio ◽  
Negative Likelihood Ratio ◽  
High Sensitivity ◽  
H Pylori ◽  
Ig G

ABSTRACT BACKGROUND: It has been proposed that the combination of gastrin-17 (G-17), pepsinogens I and II (PGI and PGII), and anti-Helicobacter pylori (H. pylori) antibodies (GastroPanel®, BIOHIT HealthCare, Helsinki, Finland) could serve as biomarkers of atrophic gastritis. OBJECTIVE: This study aimed to ensure the diagnostic accuracy of GastroPanel® and evaluate the effect of proton pump inhibitors (PPIs) on these biomarkers. METHODS: Dyspeptic patients who underwent gastrointestinal endoscopy were enrolled in the present study. Histological findings, which were the gold standard to stratify groups, were as follows: no atrophy (controls); antrum atrophy; corpus atrophy; multifocal atrophy; and neoplasia. G-17, PGI, PGII, and anti-H. pylori immunoglobulin (Ig)G antibodies were assayed using commercially available kits. The ratio of PGI/PGII was calculated. RESULTS: Among 308 patients, 159 (51.6%) were PPI users. The overall prevalence of atrophy was 43.8% (n=135). Ninety-two (29.9%) patients were H. pylori positive according to anti-H. pylori IgG levels. G-17 levels were not low in those with antrum atrophy but were high in those with corpus and multifocal atrophies. PGI levels were significantly lower in those with corpus and multifocal atrophies. The sensitivity of PGI <30 µg/L to detect corpus atrophy was 50% (95% CI 27.8-72.1%), with a specificity of 93.2% (95% CI 84.3-97.5%), a positive likelihood ratio of 7.4 (95% CI 2.9-19.2), and a negative likelihood ratio of 0.5 (95% CI 0.3-0.8). A small number of subjects (n=6) exhibited moderate to intense atrophy (4%), among whom 66.7% exhibited decreased PGI levels. PPI significantly increased the levels of G-17 and PGI, except in those with corpus and multifocal atrophies, in whom PGI levels were not increased by PPIs. CONCLUSION: GastroPanel® (Gastrin-17, PGI, and PGI/PGII ratio) did not demonstrate high sensitivity for detecting gastric atrophy.

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