scholarly journals Latiglutenase treatment for celiac disease: symptom and quality of life improvement for seropositive patients on a gluten‐free diet

GastroHep ◽  
2019 ◽  
Vol 1 (6) ◽  
pp. 293-301 ◽  
Author(s):  
Jack A. Syage ◽  
Peter H.R. Green ◽  
Chaitan Khosla ◽  
Daniel C. Adelman ◽  
Jennifer A. Sealey‐Voyksner ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Celiac Disease ◽  
Gluten Free Diet ◽  
Disease Symptom ◽  
Gluten Free ◽  
Life Improvement

Impact of a Gluten-Free Diet on Quality of Life and Health Perception in Patients with Type 1 Diabetes and Asymptomatic Celiac Disease

2021 ◽  
Author(s):  
Daniel I Weiman ◽  
Farid H Mahmud ◽  
Antoine B M Clarke ◽  
Esther Assor ◽  
Charlotte McDonald ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Type 1 Diabetes ◽  
Celiac Disease ◽  
Health Perception ◽  
Lifestyle Changes ◽  
Gluten Free Diet ◽  
Gluten Free ◽  
Gi Symptoms

Abstract Context Celiac disease (CD) is a common comorbidity seen in patients with type 1 diabetes (T1D) and is frequently asymptomatic. As chronic conditions requiring significant lifestyle changes, there are limited reports assessing changes in health-related quality of life (HRQoL) during transition to a gluten-free diet (GFD) in patients with both T1D and who are asymptomatic for CD. Objective To prospectively assess HRQoL and health perception in children and adults with T1D and asymptomatic CD after randomization to GFD versus usual diet. Design, Setting, and Participants Patients with T1D aged 8-45 years without CD symptoms were serologically screened for CD, with positive results confirmed with intestinal biopsy. Participants were randomized in an open-label fashion to a GFD or gluten-containing diet (GCD) for 12 months. Generic and diabetes-specific HRQoL and self-perceived wellness (SPW) were assessed longitudinally. Results 2,387 T1D patients were serologically screened. CD was biopsy-confirmed in 82 patients and 51 participants were randomized to a GFD (N=27) or GCD (N=24). Excellent adherence to the assigned diets was observed. Overall, no changes in generic (P=0.73) or diabetes-specific HRQoL (P=0.30), or SPW (P=0.41) were observed between groups over 12 months. HemoglobinA1c (HbA1c) and GI symptoms were consistent predictors of HRQoL and SPW. Conclusions HRQoL and SPW were not significantly impacted by the adoption of a GFD over 12 months, but worsened with symptom onset and increased HbA1c. Our findings indicate that transition to a GFD can be made successfully in this population without adversely impacting quality of life.

Lower Quality of Life and Energy in Adults and Teenagers with Celiac Disease are Associated with Greater Adherence and Knowledge About the Gluten-Free Diet

2017 ◽  
Vol 152 (5) ◽  
pp. S159
Author(s):  
Randi L. Wolf ◽  
Benjamin Lebwohl ◽  
Anne R. Lee ◽  
Norelle R. Reilly ◽  
Jennifer W. Cadenhead ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Celiac Disease ◽  
Gluten Free Diet ◽  
Gluten Free

A Cooking-Based Intervention Promotes Gluten-Free Diet Adherence and Quality of Life for Adults with Celiac Disease

2020 ◽  
Vol 18 (11) ◽  
pp. 2625-2627
Author(s):  
Randi L. Wolf ◽  
Mary Morawetz ◽  
Anne R. Lee ◽  
Pamela A. Koch ◽  
Isobel R. Contento ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Celiac Disease ◽  
Gluten Free Diet ◽  
Gluten Free ◽  
Diet Adherence

scholarly journals Evaluation of Gluten-Free Diet Efficacy for Improving Quality of Life of Patients with Celiac Disease

2021 ◽  
Vol In Press (In Press) ◽  
Author(s):  
Pezhman Alavinejad ◽  
Yosra Shafiolleh Talokdar ◽  
Zahra Shokati Ashkiki
Keyword(s):  
Quality Of Life ◽  
Celiac Disease ◽  
Cross Sectional Study ◽  
Gluten Free Diet ◽  
Gluten Free ◽  
Cross Sectional ◽  
Khuzestan Province ◽  
Before And After ◽  
One Year

Background: As the only effective treatment of celiac disease (CD) is a lifelong commitment to a gluten-free diet (GFD), this study was designed to evaluate the efficacy of GFD in the quality of life (QOL) of patients with CD to persuade them for strict commitment. Methods: In a cross-sectional study, the QOL of CD patients registered in the celiac society of Khuzestan province was evaluated and compared before and at least one year after commencing GFD using the QOL SF-36 questionnaire. Results: Overall, 200 CD patients (66 males and 134 females) were evaluated. The average age of male and female participants was 26.3 and 30.34 years, respectively (61% between 20 and 60-years-old). After GFD, complaints such as bloating (P = 0.001), abdominal pain (P = 0.001), diarrhea (P = 0.001), nausea (P = 0.001), vomiting (P = 0.03), reflux and regurgitation (P = 0.025), anorexia (P = 0.001), fatigue (P = 0.001), headache (P = 0.008), oral aphthous lesions (P = 0.014), weight loss (P = 0.001), and bone pain (P = 0.005) significantly improved while other symptoms such as muscular pain (P = 0.157), dermatitis (P = 0.083), and numbness (P = 0.317) did not show any major improvement. The average scores of QOL before and after GFD were 0.74 and 3.41, respectively, which demonstrated significant improvement (P = 0.001). This improvement was even seen among cases with sub-optimal compliance (average QOL score 3.28, P = 0.001). Conclusion: A gluten-free diet could significantly improve the quality of life of patients with celiac disease, and they should be encouraged as much as possible to be committed to this regimen.

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