Tandem integration of multipleILV5 copies and elevated transcription in polyploid yeast

Yeast ◽  
1995 ◽  
Vol 11 (4) ◽  
pp. 311-316 ◽  
Author(s):  
Suzanne M. Mithieux ◽  
Anthony S. Weiss
Keyword(s):  
Tandem Integration

scholarly journals Nitride-Based Interfacial Layers for Monolithic Tandem Integration of New Solar Energy Materials on Si: The Case of CZTS

2020 ◽  
Vol 3 (5) ◽  
pp. 4600-4609 ◽  
Author(s):  
Filipe Martinho ◽  
Alireza Hajijafarassar ◽  
Simón Lopez-Marino ◽  
Moises Espíndola-Rodríguez ◽  
Sara Engberg ◽  
...  
Keyword(s):  
Solar Energy ◽  
Energy Materials ◽  
Interfacial Layers ◽  
Solar Energy Materials ◽  
Tandem Integration

Tandem integration of complete and defective SV40 genomes in mouse-human somatic cell hybrids

Cell ◽  
1978 ◽  
Vol 15 (4) ◽  
pp. 1411-1426 ◽  
Author(s):  
M.Saveria Campo ◽  
Iain R. Cameron ◽  
M.Elizabeth Rogers
Keyword(s):  
Somatic Cell ◽  
Somatic Cell Hybrids ◽  
Human Somatic Cell ◽  
Cell Hybrids ◽  
Tandem Integration

scholarly journals Secondary Chromosomal Attachment Site and Tandem Integration of the Mobilizable Salmonella Genomic Island 1

PLoS ONE ◽  
2008 ◽  
Vol 3 (4) ◽  
pp. e2060 ◽  
Author(s):  
Benoît Doublet ◽  
George R. Golding ◽  
Michael R. Mulvey ◽  
Axel Cloeckaert
Keyword(s):  
Genomic Island ◽  
Attachment Site ◽  
Tandem Integration

scholarly journals Whole-Genome Sequencing to Identify the Genetic Etiology of a Spontaneous Thymoma Mouse Model

2021 ◽  
Vol 5 (1) ◽  
pp. 01-07
Author(s):  
Milan Radovich
Keyword(s):  
Growth Factor ◽  
Mouse Model ◽  
Whole Genome Sequencing ◽  
Genome Sequencing ◽  
Insertional Mutagenesis ◽  
Transforming Growth Factor ◽  
Insertion Site ◽  
Simian Virus 40 ◽  
Whole Genome ◽  
Tandem Integration

Background: A mouse model for thymoma was previously created serendipitously by the random introduction of a transgene consisting of a mouse α-cardiac promoter, a constitutively active human transforming growth factor-β, and a simian virus 40 integration sequence into C3HeB/FeJ mice. Previous data demonstrated that the likely cause of thymomas in the thymoma mouse model was due to insertional mutagenesis by the transgene. At the time, fluorescence in situ hybridization was used to localize the transgene to the short arm of chromosome 2 (Chr2qF2-G region). In this exploratory study, we aimed to identify the exact insertion site of the transgene as this could provide clues to the genetic causation of thymomas in humans. Materials and Methods: To identify the insertion site of the transgene, germline DNA from the thymoma mouse model was sequenced using low-pass, fragment-library, whole genome sequencing. Long-insert mate pair whole genome sequencing was employed to traverse the repetitive regions of the mouse’s genome and identify the integration site. Results: The transgene was found to be integrated into a repetitive area of the mouse genome, specifically on Chr2qF1 within the intron of the FAM227B gene. Tandem integration of the transgene was observed with enumeration of an estimated 30 copies. Initial results suggested that a nearby gene, fibroblast growth factor 7 (Fgf7), could be affected by the gene insertion. Conclusions: Whole genome sequencing of this thymoma mouse model identified the region of tandem integration of a transgene on Chr2qF1 that may have potential translational implications in helping to understand the genomic etiology of thymoma in humans.

Tandem integration of complete viral genomes can occur in nonpermissive hamster cells transformed by Linear BKV DNA with cohesive ends

Virology ◽  
1982 ◽  
Vol 120 (2) ◽  
pp. 500-503 ◽  
Author(s):  
Maria Pia Grossi ◽  
Alfredo Corallini ◽  
Guerrino Meneguzzi ◽  
Nicole Chenciner ◽  
Giuseppe Barbanti-Brodano ◽  
...  
Keyword(s):  
Viral Genomes ◽  
Tandem Integration

Tandem Integration of Avian Retroviruses in Double-Infected Cells

Intervirology ◽  
1980 ◽  
Vol 13 (4) ◽  
pp. 241-252
Author(s):  
Guido Carloni ◽  
Nicholas Stedman ◽  
Jana Hillova ◽  
Maria Marx ◽  
Miroslav Hill
Keyword(s):  
Infected Cells ◽  
Tandem Integration
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