Identification of potential cell-surface proteins inCandida albicansand investigation of the role of a putative cell-surface glycosidase in adhesion and virulence

Yeast ◽  
2004 ◽  
Vol 21 (4) ◽  
pp. 285-302 ◽  
Author(s):  
Christine Alberti-Segui ◽  
Arturo J. Morales ◽  
Heming Xing ◽  
Marco M. Kessler ◽  
Debra Aker Willins ◽  
...  
Keyword(s):  
Cell Surface ◽  
Surface Proteins ◽  
Cell Surface Proteins

scholarly journals Find and fuse: Unsolved mysteries in sperm–egg recognition

PLoS Biology ◽  
2020 ◽  
Vol 18 (11) ◽  
pp. e3000953
Author(s):  
Enrica Bianchi ◽  
Gavin J. Wright
Keyword(s):  
Cell Surface ◽  
Sperm Cell ◽  
Surface Proteins ◽  
Secreted Proteins ◽  
Egg Recognition ◽  
Cell Surface Proteins ◽  
Molecular Events ◽  
Eukaryotic Species ◽  
Fundamental Process

Sexual reproduction is such a successful way of creating progeny with subtle genetic variations that the vast majority of eukaryotic species use it. In mammals, it involves the formation of highly specialised cells: the sperm in males and the egg in females, each carrying the genetic inheritance of an individual. The interaction of sperm and egg culminates with the fusion of their cell membranes, triggering the molecular events that result in the formation of a new genetically distinct organism. Although we have a good cellular description of fertilisation in mammals, many of the molecules involved remain unknown, and especially the identity and role of cell surface proteins that are responsible for sperm–egg recognition, binding, and fusion. Here, we will highlight and discuss these gaps in our knowledge and how the role of some recently discovered sperm cell surface and secreted proteins contribute to our understanding of this fundamental process.

The role of cell surface proteins gene expression in diagnosis, prognosis, and drug resistance of colorectal cancer: In silico analysis and validation

2021 ◽  
Vol 123 ◽  
pp. 104688
Author(s):  
Nasrin Nazempour ◽  
Mohammad Hossein Taleqani ◽  
Navid Taheri ◽  
Amir Hossein Haji Ali Asgary Najafabadi ◽  
Alireza Shokrollahi ◽  
...  
Keyword(s):  
Gene Expression ◽  
Colorectal Cancer ◽  
Drug Resistance ◽  
Cell Surface ◽  
In Silico ◽  
In Silico Analysis ◽  
Surface Proteins ◽  
Cell Surface Proteins ◽  
Silico Analysis

scholarly journals Cell Surface Proteins in Hepatocellular Carcinoma: From Bench to Bedside

Vaccines ◽  
2020 ◽  
Vol 8 (1) ◽  
pp. 41
Author(s):  
Gabriel Siracusano ◽  
Maria Tagliamonte ◽  
Luigi Buonaguro ◽  
Lucia Lopalco
Keyword(s):  
Hepatocellular Carcinoma ◽  
Cell Surface ◽  
Intracellular Signaling ◽  
Surface Proteins ◽  
Signaling Proteins ◽  
Cell Surface Proteins ◽  
Neoplastic Diseases ◽  
Extracellular Environment

Cell surface proteins act as the go-between in carrying the information from the extracellular environment to the intracellular signaling proteins. However, these proteins are often deregulated in neoplastic diseases, including hepatocellular carcinoma. This review discusses several recent studies that have investigated the role of cell surface proteins in the occurrence and progression of HCC, highlighting the possibility to use them as biomarkers of the disease and/or targets for vaccines and therapeutics.

scholarly journals Role of SrtA in Pathogenicity of Staphylococcus lugdunensis

2020 ◽  
Vol 8 (12) ◽  
pp. 1975
Author(s):  
Muzaffar Hussain ◽  
Christian Kohler ◽  
Karsten Becker
Keyword(s):  
Cell Wall ◽  
Cell Surface ◽  
Biofilm Formation ◽  
Surface Proteins ◽  
Transcription Level ◽  
Coagulase Negative Staphylococci ◽  
Staphylococcus Lugdunensis ◽  
Cell Surface Proteins ◽  
Mutant Strains

Among coagulase-negative staphylococci (CoNS), Staphylococcus lugdunensis has a special position as causative agent of aggressive courses of infectious endocarditis (IE) more reminiscent of IEs caused by Staphylococcus aureus than those by CoNS. To initiate colonization and invasion, bacterial cell surface proteins are required; however, only little is known about adhesion of S. lugdunensis to biotic surfaces. Cell surface proteins containing the LPXTG anchor motif are covalently attached to the cell wall by sortases. Here, we report the functionality of Staphylococcus lugdunensis sortase A (SrtA) to link LPXTG substrates to the cell wall. To determine the role of SrtA dependent surface proteins in biofilm formation and binding eukaryotic cells, we generated SrtA-deficient mutants (ΔsrtA). These mutants formed a smaller amount of biofilm and bound less to immobilized fibronectin, fibrinogen, and vitronectin. Furthermore, SrtA absence affected the gene expression of two different adhesins on transcription level. Surprisingly, we found no decreased adherence and invasion in human cell lines, probably caused by the upregulation of further adhesins in ΔsrtA mutant strains. In conclusion, the functionality of S. lugdunensis SrtA in anchoring LPXTG substrates to the cell wall let us define it as the pathogen’s housekeeping sortase.

Ecto-ADP-ribose Transferases: Cell-Surface Response to Local Tissue Injury

Physiology ◽  
2005 ◽  
Vol 20 (6) ◽  
pp. 374-381 ◽  
Author(s):  
Anna Zolkiewska
Keyword(s):  
Cell Surface ◽  
Tissue Injury ◽  
Membrane Receptors ◽  
Surface Proteins ◽  
Main Role ◽  
Membrane Stress ◽  
Cell Surface Proteins ◽  
Physiological Conditions ◽  
Arginine Residues

Ecto-ADP-ribose transferases (ecto-ARTs) catalyze the transfer of ADP-ribose from NAD+ to arginine residues in cell-surface proteins. Since the concentration of extracellular NAD+ is very low under normal physiological conditions but rises significantly upon tissue injury or membrane stress, it is postulated that the main role of ecto-ARTs is to ADP-ribosylate and regulate the function of certain membrane receptors in response to elevated levels of NAD+.

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