scholarly journals Understanding the potential of hepatitis C virus internal ribosome entry site domains to modulate translation initiation via their structure and function

2014 ◽  
Vol 6 (2) ◽  
pp. 211-224 ◽  
Author(s):  
Anas Khawaja ◽  
Vaclav Vopalensky ◽  
Martin Pospisek
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Translation Initiation ◽  
Internal Ribosome Entry Site ◽  
Structure And Function ◽  
Entry Site ◽  
Internal Ribosome Entry ◽  
And Function ◽  
Virus Internal Ribosome Entry

The Hepatitis C Virus Internal Ribosome Entry Site Adopts an Ion-dependent Tertiary Fold

1999 ◽  
Vol 292 (3) ◽  
pp. 513-529 ◽  
Author(s):  
Jeffrey S. Kieft ◽  
Kaihong Zhou ◽  
Ronald Jubin ◽  
Michael G. Murray ◽  
Johnson Y.N. Lau ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Internal Ribosome Entry Site ◽  
Entry Site ◽  
Internal Ribosome Entry ◽  
Virus Internal Ribosome Entry

The hepatitis C virus internal ribosome-entry site: a new target for antiviral research

2002 ◽  
Vol 30 (2) ◽  
pp. 140-145 ◽  
Author(s):  
J. Gallego ◽  
G. Varani
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Translation Initiation ◽  
Internal Ribosome Entry Site ◽  
Ribosomal Subunit ◽  
Initiation Factor ◽  
Entry Site ◽  
Viral Protein Synthesis ◽  
Initiation Mechanism ◽  
Internal Ribosome Entry

The hepatitis C virus (HCV) is the main causative agent of non-A, non-B hepatitis in humans and a major cause of mortality and morbidity in the world. Currently there is no effective treatment available for the infection caused by this virus, whose replication depends on an unusual translation-initiation mechanism. The viral RNA contains an internal ribosome-entry site (IRES) that is recognized specifically by the small ribosomal subunit and by eukaryotic initiation factor 3, and these interactions allow cap (7-methylguanine nucleotide)-independent initiation of viral protein synthesis. In this article, we review the structure and mechanism of translation initiation of the HCV IRES, and its potential as a target for novel antivirals.

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