Advancements in release‐active antimicrobial biomaterials: A journey from release to relief

2021 ◽  
Author(s):  
Brinta Bhattacharjee ◽  
Sreyan Ghosh ◽  
Dipanjana Patra ◽  
Jayanta Haldar
Keyword(s):  
Antimicrobial Biomaterials

Antimicrobial biomaterials based on carbon nanotubes dispersed in poly(lactic-co-glycolic acid)

Nanoscale ◽  
2010 ◽  
Vol 2 (9) ◽  
pp. 1789 ◽  
Author(s):  
Seyma Aslan ◽  
Codruta Zoican Loebick ◽  
Seoktae Kang ◽  
Menachem Elimelech ◽  
Lisa D. Pfefferle ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Glycolic Acid ◽  
Antimicrobial Biomaterials

scholarly journals Antifouling and antimicrobial biomaterials: an overview

Apmis ◽  
2017 ◽  
Vol 125 (4) ◽  
pp. 392-417 ◽  
Author(s):  
Iolanda Francolini ◽  
Claudia Vuotto ◽  
Antonella Piozzi ◽  
Gianfranco Donelli
Keyword(s):  
Antimicrobial Biomaterials

scholarly journals Novel Biocatalytic Polymer-Based Antimicrobial Coatings as Potential Ureteral Biomaterial: Preparation andIn VitroPerformance Evaluation

2010 ◽  
Vol 55 (2) ◽  
pp. 845-853 ◽  
Author(s):  
Rachna N. Dave ◽  
Hiren M. Joshi ◽  
Vayalam P. Venugopalan
Keyword(s):  
Bacterial Colonization ◽  
Antibacterial Properties ◽  
Enzyme Concentration ◽  
Urinary Catheters ◽  
Antimicrobial Coatings ◽  
Modified Polymer ◽  
Release Studies ◽  
Rate Controlled ◽  
Antimicrobial Biomaterials

ABSTRACTCatheters and other indwelling devices placed inside human body are prone to bacterial infection, causing serious risk to patients. Infections associated with implants are difficult to resolve, and hence the prevention of bacterial colonization of such surfaces is quite appropriate. In this context, the development of novel antimicrobial biomaterials is currently gaining momentum. We describe here the preparation and antibacterial properties of an enzyme-embedded polycaprolactone (PCL)-based coating, coimpregnated with the antibiotic gentamicin sulfate (GS). The enzyme uses PCL itself as substrate; as a result, the antibiotic gets released at a rate controlled by the degradation of the PCL base.In vitrodrug release studies demonstrated sustained release of GS from the PCL film throughout its lifetime. By modulating the enzyme concentration in the PCL film, we were able to vary the lifetime of the coating from 33 h to 16 days. In the end, the polymer is completely degraded, delivering the entire load of the antibiotic. The polymer exhibited antibacterial properties against three test isolates:Escherichia coli,Pseudomonas aeruginosa, andStaphylococcus aureus. Foley urinary catheters coated with the modified polymer exhibited sustainedin vitrorelease of GS over a 60-h period. The results suggest that the antibiotic-plus-enzyme-loaded polymer can be used as tunable self-degrading antimicrobial biomaterial coating on catheters.

Bimetallic alginate nanocomposites: New antimicrobial biomaterials for biomedical application

2018 ◽  
Vol 212 ◽  
pp. 32-36 ◽  
Author(s):  
Ivana Malagurski ◽  
Steva Levic ◽  
Miodrag Mitric ◽  
Vladimir Pavlovic ◽  
Suzana Dimitrijevic-Brankovic
Keyword(s):  
Biomedical Application ◽  
Antimicrobial Biomaterials

scholarly journals Antimicrobial biomaterials in the prevention and local treatment of infection in orthopedics

2019 ◽  
Vol 83 (6) ◽  
pp. 221-228
Author(s):  
Irenusz Babiak ◽  
◽  
Piotr Pędzisz ◽  
Jakub Janowicz ◽  
Paweł Małdyk
Keyword(s):  
Local Treatment ◽  
Antimicrobial Biomaterials ◽  
Treatment Of Infection

scholarly journals New Antimicrobial Biomaterials for the Reconstruction of Craniofacial Bone Defects

Coatings ◽  
2020 ◽  
Vol 10 (7) ◽  
pp. 678 ◽  
Author(s):  
Andreea Elena Miron (Lungu) ◽  
Marioara Moldovan ◽  
Cristina Alexandra Prejmerean ◽  
Doina Prodan ◽  
Mihaela Vlassa ◽  
...  
Keyword(s):  
Inhibitory Concentration ◽  
Glass Fibers ◽  
Antimicrobial Effect ◽  
Bone Defects ◽  
Critical Factors ◽  
Term Survival ◽  
Bone Surgery ◽  
Surgical Infections ◽  
Antimicrobial Biomaterials

Reconstructive bone surgery of the head and neck could prove challenging in terms of postoperative healing and recovery. Fighting infection during the healing period is one of the critical factors of the long-term survival of an implant. The aim of the study was to develop an innovative composition suitable for an antibacterial craniofacial implant that should have the capacity to continuously and constantly release the amount of gentamicin necessary to prevent the post-surgical infections. For this purpose, a series of composite materials based on dimethacrylic monomers, hydroxyapatite and ZrO2, with (series B) or without the addition of polymethyl methacrylate (series A), reinforced with woven E-glass fibers (FRC) were obtained using the laminate lay-up process. Gentamicin was included in all FRC sample matrices to confer an antimicrobial effect. The results show that after extraction of the residual monomers from the FRC samples in different solvents (chloroform, acetone and ethyl alcohol), the cumulative amount of released gentamicin after 12 days was between 7.05–11.38 mg for A samples and 11.21–14.52 mg for B samples. The microbiological protocol showed that gentamicin induces a two weeks-lasting antimicrobial effect maintained over the minimal inhibitory concentration for P. aeruginosa and S. aureus.

scholarly journals Infections associated with mesh repairs of abdominal wall hernias: Are antimicrobial biomaterials the longed-for solution?

Biomaterials ◽  
2018 ◽  
Vol 167 ◽  
pp. 15-31 ◽  
Author(s):  
O. Guillaume ◽  
R. Pérez-Tanoira ◽  
R. Fortelny ◽  
H. Redl ◽  
T.F. Moriarty ◽  
...  
Keyword(s):  
Abdominal Wall ◽  
Antimicrobial Biomaterials

Abstracts of a joint meeting of the Association of Clinical Oral Microbiologists and the Biofilm Club held at the Eastman Dental Institute, University College London on 2 March 2004

Biofilms ◽  
2004 ◽  
Vol 1 (2) ◽  
pp. 139-145
Keyword(s):  
Infection Control ◽  
Infection Model ◽  
Periodontal Pathogens ◽  
C Elegans ◽  
University College London ◽  
Dental Unit Waterlines ◽  
Dental Setting ◽  
Antimicrobial Biomaterials

Principles of antimicrobial biomaterials: why they do not (usually) workCharacterization of bacterial adhesion onto surfaces of stainless steel by micromanipulationYersinia spp./C. elegans infection model: biofilms on a biotic surfacePeriodontal pathogens in dental unit waterlinesBiofilms as reservoirs of antibiotic resistanceSystemic antimicrobials and periodontitis – a classic biofilm diseasePrion disease in the dental settingReviewing the role of biofilms in infection controlInfection control in dental technology laboratoriesReview of the treatment aspects of dental unit water systems

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