scholarly journals Opportunities and challenges for the clinical translation of structured DNA assemblies as gene therapeutic delivery and vaccine vectors

2020 ◽  
Vol 13 (1) ◽  
Author(s):  
Marina A. Dobrovolskaia ◽  
Mark Bathe
Keyword(s):  
Clinical Translation ◽  
Vaccine Vectors ◽  
Therapeutic Delivery

Nonlinear dynamics of a shell encapsulated microbubble near solid boundary in an ultrasonic field

2020 ◽  
Vol 14 (3) ◽  
pp. 7235-7243
Author(s):  
N.M. Ali ◽  
F. Dzaharudin ◽  
E.A. Alias
Keyword(s):  
Oscillation Amplitude ◽  
Ultrasonic Field ◽  
Dynamical Behaviour ◽  
Ultrasound Contrast Agents ◽  
Chaotic Behaviour ◽  
Solid Boundary ◽  
Driving Frequency ◽  
Pressure Amplitude ◽  
Radial Expansion ◽  
Therapeutic Delivery

Microbubbles have the potential to be used for diagnostic imaging and therapeutic delivery. However, the transition from microbubbles currently being used as ultrasound contrast agents to achieve its’ potentials in the biomedical field requires more in depth understanding. Of particular importance is the influence of microbubble encapsulation of a microbubble near a vessel wall on the dynamical behaviour as it stabilizes the bubble. However, many bubble studies do not consider shell encapsulation in their studies. In this work, the dynamics of an encapsulated microbubble near a boundary was studied by numerically solving the governing equations for microbubble oscillation. In order to elucidate the effects of a boundary to the non-linear microbubble oscillation the separation distances between microbubble will be varied along with the acoustic driving. The complex nonlinear vibration response was studied in terms of bifurcation diagrams and the maximum radial expansion. It was found that the increase in distance between the boundary and the encapsulated bubble will increase the oscillation amplitude. When the value of pressure amplitude increased the single bubble is more likely to exhibit the chaotic behaviour and maximum radius also increase as the inter wall-bubble distance is gradually increased. While, with higher driving frequency the maximum radial expansion decreases and suppress the chaotic behaviour.

Baculoviruses as vaccine vectors

2009 ◽  
Vol 24 (6) ◽  
pp. 608-615
Author(s):  
Takayuki Abe ◽  
Hideki Tani ◽  
Yoshiharu Matsuura
Keyword(s):  
Vaccine Vectors

Species Differences in Hepatocyte-Directed Gene Transfer: Implications for Clinical Translation

2009 ◽  
Vol 9 (2) ◽  
pp. 83-90 ◽  
Author(s):  
Frank Jacobs ◽  
Yingmei Feng ◽  
Eline Craeyveld ◽  
Joke Lievens ◽  
Jan Snoeys ◽  
...  
Keyword(s):  
Gene Transfer ◽  
Species Differences ◽  
Clinical Translation

A Comprehensive Review on Role of Nanoparticles in Therapeutic Delivery of Medicine

2018 ◽  
Vol 5 (4) ◽  
Author(s):  
Sandeep Rathor ◽  
D.C Bhatt ◽  
Sheikh Aamir ◽  
S.K. Singh ◽  
Vikash Kumar
Keyword(s):  
Comprehensive Review ◽  
Therapeutic Delivery

Phosphatase Makes Recombinant Salmonella Vaccine Vectors Safer

2011 ◽  
Vol 6 (11) ◽  
pp. 471-472
Author(s):  
Carol Potera
Keyword(s):  
Vaccine Vectors

scholarly journals Preparation and clinical translation of 99mTc-PSMA-11 for SPECT imaging of prostate cancer

MedChemComm ◽  
2019 ◽  
Vol 10 (12) ◽  
pp. 2111-2117 ◽  
Author(s):  
Kusum Vats ◽  
Kanhaiyalal Agrawal ◽  
Rohit Sharma ◽  
Haladhar Dev Sarma ◽  
Drishty Satpati ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Patients ◽  
Spect Imaging ◽  
Clinical Translation

This study explores the feasibility of radiolabeling the HBED-CC-PSMA (PSMA-11) ligand with Tc-99m for SPECT imaging of prostate cancer patients.

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