Dendrimer-entrapped metal colloids as imaging agents

2015 ◽  
Vol 7 (5) ◽  
pp. 678-690 ◽  
Author(s):  
Du Li ◽  
Shihui Wen ◽  
Xiangyang Shi
Keyword(s):  
Imaging Agents ◽  
Metal Colloids

EVIDENCE FOR POTASSIUM METAL COLLOIDS IN ION-IRRADIATED KI

1976 ◽  
Vol 37 (C7) ◽  
pp. C7-510-C7-517 ◽  
Author(s):  
G. CHASSAGNE ◽  
J. SERUGHETTI ◽  
L. W. HOBBS
Keyword(s):  
Metal Colloids

Basic Studies of Various 99mTc-Labelled Renal Agents and Clinical Application of 99mTc-Malate

1977 ◽  
Vol 16 (01) ◽  
pp. 36-41 ◽  
Author(s):  
T. Machida ◽  
M. Miki ◽  
M. Ueda ◽  
A. Tanaka ◽  
I. Ikeda
Keyword(s):  
Excretion Rate ◽  
Animal Experiments ◽  
Imaging Agents ◽  
Half Time ◽  
Clinical Experiences ◽  
Labelling Efficiency ◽  
Urinary Excretion Rate ◽  
Renal Imaging ◽  
The Past ◽  
Basic Studies

SummaryVarious renal imaging agents that were reported in the past and a new agent, 99mTc-malate as well as 99mTc-cystein acetazolamide complex were prepared using electrolysis and electrochemical methods. These were studied for their labelling efficiency. After animal experiments with selected 99mTc-com- pounds, 99mTc-rnalate proved to be sufficient for renal imaging with adequate concentration. 99mTcmalate differs from other renal imaging agents in the utilization of endogeneous metabolic product.The first half time of 99mTc-malate in humans is 17 minutes, on the average, and the urinary excretion rate of 99mTc-malate is 36±6.05% in 1 hour after intravenous administration, 44 ± 3.41% in 2 hours and 50 + 5.62% in 3 hours.In our 40 clinical experiences of 99m-Tc-rnalate, most cases demonstrated quite clear renal images in the serial scintiphotos except cases whose serum creatinines were over 4.5 mg/dl.

Toxicity of Magnetic Resonance Imaging Agents: Small Molecule and Nanoparticle

2013 ◽  
Vol 13 (4) ◽  
pp. 434-445 ◽  
Author(s):  
Yongmin Chang ◽  
Gang Ho Lee ◽  
Tae-Jeong Kim ◽  
Kwon-Seok Chae
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Small Molecule ◽  
Imaging Agents ◽  
Resonance Imaging

Synthesis and Evaluation of 18F-INER-1577-3 as a Central Nervous System (CNS) Histone Deacetylase Imaging Agent

2020 ◽  
Vol 16 (8) ◽  
pp. 978-990
Author(s):  
Ming-Hsin Li ◽  
Han-Chih Chang ◽  
Chun-Fang Feng ◽  
Hung-Wen Yu ◽  
Chyng-Yann Shiue
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Histone Deacetylases ◽  
Authentic Sample ◽  
Cancer Cell Line ◽  
Radiochemical Yield ◽  
Imaging Agent ◽  
Whole Body ◽  
Imaging Agents ◽  
Synthesis Time

Background:: Epigenetic dysfunction is implicated in many neurologic, psychiatric and oncologic diseases. Consequently, histone deacetylases (HDACs) inhibitors have been developed as therapeutic and imaging agents for these diseases. However, only a few radiotracers have been developed as HDACs imaging agents for the central nervous system (CNS). We report herein the synthesis and evaluation of [18F]INER-1577-3 ([18F]5) as an HDACs imaging agent for CNS. Methods:: [18F]INER-1577-3 ([18F]5) was synthesized by two methods: one-step (A) and two-step (B) methods. Briefly, radiofluorination of the corresponding precursors (11, 12) with K[18F]/K2.2.2 followed by purifications with HPLC gave ([18F]5). The quality of [18F]INER- 1577-3 synthesized by these methods was verified by HPLC and TLC as compared to an authentic sample. The inhibitions of [18F]INER-1577-3 and related HDACs inhibitors on tumor cells growth were carried out with breast cancer cell line 4T1 and MCF-7. The whole-body and brain uptake of [18F]INER-1577-3 in rats and AD mice were determined using a micro-PET scanner and the data was analyzed using PMOD. Results: : The radiochemical yield of [18F]INER-1577-3 synthesized by these two methods was 1.4 % (Method A) and 8.8% (Method B) (EOB), respectively. The synthesis time was 115 min and 100 min, respectively, from EOB. The inhibition studies showed that INER-1577-3 has a significant inhibitory effect in HDAC6 and HDAC8 but not HDAC2. PET studies in rats and AD mice showed a maximum at about 15 min postinjection for the whole brain of a rat (0.47 ± 0.03 %ID/g), SAMP8 mice (5.63 ± 1.09 %ID/g) and SAMR1 mice (7.23 ± 1.21 %ID/g). Conclusion:: This study showed that INER-1577-3 can inhibit tumor cell growth and is one of a few HDACs inhibitors that can penetrate the blood-brain barrier (BBB) and monitor HDAC activities in AD mice. Thus, [18F]INER-1577-3 may be a potent HDACs imaging agent, especially for CNS.

scholarly journals Peripheral ganglia in healthy rats as target structures for the evaluation of PSMA imaging agents

BMC Cancer ◽  
2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Heike Endepols ◽  
Agnieszka Morgenroth ◽  
Boris D. Zlatopolskiy ◽  
Philipp Krapf ◽  
Johannes Zischler ◽  
...  
Keyword(s):  
Imaging Agents
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