Nanovector-mediated drug delivery for spinal cord injury treatment

2014 ◽  
Vol 6 (5) ◽  
pp. 506-515 ◽  
Author(s):  
Ilaria Caron ◽  
Simonetta Papa ◽  
Filippo Rossi ◽  
Gianluigi Forloni ◽  
Pietro Veglianese
Keyword(s):  
Drug Delivery ◽  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Cord Injury ◽  
Injury Treatment

scholarly journals Spinal‐Cord Injury Treatment: Effective Modulation of CNS Inhibitory Microenvironment using Bioinspired Hybrid‐Nanoscaffold‐Based Therapeutic Interventions (Adv. Mater. 43/2020)

2020 ◽  
Vol 32 (43) ◽  
pp. 2070325
Author(s):  
Letao Yang ◽  
Brian M. Conley ◽  
Susana R. Cerqueira ◽  
Thanapat Pongkulapa ◽  
Shenqiang Wang ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Therapeutic Interventions ◽  
Cord Injury ◽  
Injury Treatment

Multiple drug delivery hydrogel system for spinal cord injury repair strategies

2012 ◽  
Vol 159 (2) ◽  
pp. 271-280 ◽  
Author(s):  
Giuseppe Perale ◽  
Filippo Rossi ◽  
Marco Santoro ◽  
Marco Peviani ◽  
Simonetta Papa ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Multiple Drug ◽  
Injury Repair ◽  
Cord Injury ◽  
Multiple Drug Delivery ◽  
Hydrogel System

scholarly journals Functional resveratrol-biodegradable manganese doped silica nanoparticles for the spinal cord injury treatment

2022 ◽  
Vol 13 ◽  
pp. 100177
Author(s):  
Xue Jiang ◽  
Xiaoyao Liu ◽  
Qi Yu ◽  
Wenwen Shen ◽  
Xifan Mei ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Silica Nanoparticles ◽  
Cord Injury ◽  
Injury Treatment

Therapeutic Efficacy-Potentiated and Diseased Organ-Targeting Nanovesicles Derived from Mesenchymal Stem Cells for Spinal Cord Injury Treatment

Nano Letters ◽  
2018 ◽  
Vol 18 (8) ◽  
pp. 4965-4975 ◽  
Author(s):  
Han Young Kim ◽  
Hemant Kumar ◽  
Min-Jae Jo ◽  
Jonghoon Kim ◽  
Jeong-Kee Yoon ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Stem Cells ◽  
Spinal Cord Injury ◽  
Mesenchymal Stem Cells ◽  
Therapeutic Efficacy ◽  
Cord Injury ◽  
Injury Treatment ◽  
Organ Targeting

scholarly journals Synthesis and Characterization of a Silica-Based Drug Delivery System for Spinal Cord Injury Therapy

2019 ◽  
Vol 11 (1) ◽  
Author(s):  
Guodong Sun ◽  
Shenghui Zeng ◽  
Xu Liu ◽  
Haishan Shi ◽  
Renwen Zhang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Mesoporous Silica ◽  
Drug Delivery System ◽  
Delivery System ◽  
Central Component ◽  
High Dose ◽  
Interleukin 17 ◽  
Cord Injury

Abstract Acute inflammation is a central component in the progression of spinal cord injury (SCI). Anti-inflammatory drugs used in the clinic are often administered systemically at high doses, which can paradoxically increase inflammation and result in drug toxicity. A cluster-like mesoporous silica/arctigenin/CAQK composite (MSN-FC@ARC-G) drug delivery system was designed to avoid systemic side effects of high-dose therapy by enabling site-specific drug delivery to the spinal cord. In this nanosystem, mesoporous silica was modified with the FITC fluorescent molecule and CAQK peptides that target brain injury and SCI sites. The size of the nanocarrier was kept at approximately 100 nm to enable penetration of the blood–brain barrier. Arctigenin, a Chinese herbal medicine, was loaded into the nanosystem to reduce inflammation. The in vivo results showed that MSN-FC@ARC-G could attenuate inflammation at the injury site. Behavior and morphology experiments suggested that MSN-FC@ARC-G could diminish local microenvironment damage, especially reducing the expression of interleukin-17 (IL-17) and IL-17-related inflammatory factors, inhibiting the activation of astrocytes, thus protecting neurons and accelerating the recovery of SCI. Our study demonstrated that this novel, silica-based drug delivery system has promising potential for clinical application in SCI therapy.

scholarly journals Neural stem/progenitor cell transplantation for spinal cord injury treatment; A systematic review and meta-analysis

Neuroscience ◽  
2016 ◽  
Vol 322 ◽  
pp. 377-397 ◽  
Author(s):  
M. Yousefifard ◽  
V. Rahimi-Movaghar ◽  
F. Nasirinezhad ◽  
M. Baikpour ◽  
S. Safari ◽  
...  
Keyword(s):  
Systematic Review ◽  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Cell Transplantation ◽  
Progenitor Cell ◽  
Meta Analysis ◽  
Cord Injury ◽  
Injury Treatment
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