scholarly journals Adult gastric stem cells and their niches

2017 ◽  
Vol 6 (2) ◽  
pp. e261 ◽  
Author(s):  
Sina Bartfeld ◽  
Bon-Kyoung Koo
Keyword(s):  
Stem Cells ◽  
Gastric Stem Cells

scholarly journals Mist1 Expressing Gastric Stem Cells Maintain the Normal and Neoplastic Gastric Epithelium and Are Supported by a Perivascular Stem Cell Niche

Cancer Cell ◽  
2015 ◽  
Vol 28 (6) ◽  
pp. 800-814 ◽  
Author(s):  
Yoku Hayakawa ◽  
Hiroshi Ariyama ◽  
Jitka Stancikova ◽  
Kosuke Sakitani ◽  
Samuel Asfaha ◽  
...  
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Stem Cell Niche ◽  
Gastric Epithelium ◽  
Cell Niche ◽  
Gastric Stem Cells

scholarly journals Distinct Localization of Mature HGF from its Precursor Form in Developing and Repairing the Stomach

2019 ◽  
Vol 20 (12) ◽  
pp. 2955 ◽  
Author(s):  
Nawaphat Jangphattananont ◽  
Hiroki Sato ◽  
Ryu Imamura ◽  
Katsuya Sakai ◽  
Yumi Terakado ◽  
...  
Keyword(s):  
Stem Cells ◽  
Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Fluorescent Protein ◽  
Muscle Cells ◽  
Gastric Injury ◽  
Single Chain ◽  
Close Relationship ◽  
Green Fluorescent ◽  
Gastric Stem Cells

Hepatocyte growth factor (HGF) is secreted as an inactive single-chain HGF (scHGF); however, only proteolytically processed two-chain HGF (tcHGF) can activate the MET receptor. We investigated the localization of tcHGF and activated/phosphorylated MET (pMET) using a tcHGF-specific antibody. In day 16.5 mouse embryos, total HGF (scHGF + tcHGF) was mainly localized in smooth muscle cells close to, but separate from, MET-positive epithelial cells in endodermal organs, including the stomach. In the adult stomach, total HGF was localized in smooth muscle cells, and tcHGF was mainly localized in the glandular base region. Immunostaining for pMET and Lgr5-driven green fluorescent protein (GFP) indicated that pMET localization overlapped with Lgr5+ gastric stem cells. HGF promoted organoid formation similar to EGF, indicating the potential for HGF to promote the survival and growth of gastric stem cells. pMET and tcHGF localizations changed during regeneration following gastric injury. These results indicate that MET is constantly activated in gastric stem cells and that the localization of pMET differs from the primary localization of precursor HGF but has a close relationship to tcHGF. Our results suggest the importance of the microenvironmental generation of tcHGF in the regulation of development, regeneration, and stem cell behavior.

Mechanisms of Field Cancerization in the Human Stomach: The Expansion and Spread of Mutated Gastric Stem Cells

2008 ◽  
Vol 134 (2) ◽  
pp. 500-510 ◽  
Author(s):  
Stuart A.C. McDonald ◽  
Laura C. Greaves ◽  
Lydia Gutierrez–Gonzalez ◽  
Manuel Rodriguez–Justo ◽  
Maesha Deheragoda ◽  
...  
Keyword(s):  
Stem Cells ◽  
Human Stomach ◽  
Field Cancerization ◽  
Gastric Stem Cells
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