scholarly journals Asymmetric cell division in the Drosophila bristle lineage: from the polarization of sensory organ precursor cells to Notch-mediated binary fate decision

2015 ◽  
Vol 4 (3) ◽  
pp. 299-309 ◽  
Author(s):  
François Schweisguth
Keyword(s):  
Cell Division ◽  
Asymmetric Cell Division ◽  
Precursor Cells ◽  
Sensory Organ ◽  
Sensory Organ Precursor ◽  
Fate Decision

scholarly journals Sanpodo controls sensory organ precursor fate by directing Notch trafficking and binding γ-secretase

2013 ◽  
Vol 201 (3) ◽  
pp. 439-448 ◽  
Author(s):  
Alok Upadhyay ◽  
Vasundhara Kandachar ◽  
Diana Zitserman ◽  
Xin Tong ◽  
Fabrice Roegiers
Keyword(s):  
Notch Signaling ◽  
Cell Fate ◽  
Daughter Cell ◽  
Asymmetric Cell Division ◽  
Notch Receptor ◽  
Receptor Internalization ◽  
Sensory Organ ◽  
Cell Fates ◽  
Cellular Context ◽  
Sensory Organ Precursor

In Drosophila peripheral neurogenesis, Notch controls cell fates in sensory organ precursor (SOP) cells. SOPs undergo asymmetric cell division by segregating Numb, which inhibits Notch signaling, into the pIIb daughter cell after cytokinesis. In contrast, in the pIIa daughter cell, Notch is activated and requires Sanpodo, but its mechanism of action has not been elucidated. As Sanpodo is present in both pIIa and pIIb cells, a second role for Sanpodo in regulating Notch signaling in the low-Notch pIIb cell has been proposed. Here we demonstrate that Sanpodo regulates Notch signaling levels in both pIIa and pIIb cells via distinct mechanisms. The interaction of Sanpodo with Presenilin, a component of the γ-secretase complex, was required for Notch activation and pIIa cell fate. In contrast, Sanpodo suppresses Notch signaling in the pIIb cell by driving Notch receptor internalization. Together, these results demonstrate that a single protein can regulate Notch signaling through distinct mechanisms to either promote or suppress signaling depending on the local cellular context.

scholarly journals Overexpression of Partner of Numb Induces Asymmetric Distribution of the PI4P 5-Kinase Skittles in Mitotic Sensory Organ Precursor Cells in Drosophila

PLoS ONE ◽  
2008 ◽  
Vol 3 (8) ◽  
pp. e3072 ◽  
Author(s):  
Carolina N. L. R. Perdigoto ◽  
Louis Gervais ◽  
Erin Overstreet ◽  
Janice Fischer ◽  
Antoine Guichet ◽  
...  
Keyword(s):  
Precursor Cells ◽  
Sensory Organ ◽  
Asymmetric Distribution ◽  
Sensory Organ Precursor

scholarly journals Regulation of cortical stability by RhoGEF3 in mitotic Sensory Organ Precursor cells inDrosophila

Biology Open ◽  
2017 ◽  
Vol 6 (12) ◽  
pp. 1851-1860 ◽  
Author(s):  
Lydie Couturier ◽  
Khalil Mazouni ◽  
Fred Bernard ◽  
Charlotte Besson ◽  
Elodie Reynaud ◽  
...  
Keyword(s):  
Precursor Cells ◽  
Sensory Organ ◽  
Sensory Organ Precursor

scholarly journals Drosophila E-Cadherin Regulates the Orientation of Asymmetric Cell Division in the Sensory Organ Lineage

2002 ◽  
Vol 12 (2) ◽  
pp. 95-104 ◽  
Author(s):  
Roland Le Borgne ◽  
Yohanns Bellaı̈che ◽  
François Schweisguth
Keyword(s):  
Cell Division ◽  
Asymmetric Cell Division ◽  
Sensory Organ ◽  
E Cadherin

scholarly journals Wg Signaling via Zw3 and Mad Restricts Self-Renewal of Sensory Organ Precursor Cells in Drosophila

Genetics ◽  
2011 ◽  
Vol 189 (3) ◽  
pp. 809-824 ◽  
Author(s):  
Janine C. Quijano ◽  
Michael J. Stinchfield ◽  
Stuart J. Newfeld
Keyword(s):  
Precursor Cells ◽  
Sensory Organ ◽  
Self Renewal ◽  
Sensory Organ Precursor
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