scholarly journals Autoimmune polyendocrine syndrome in a standard poodle with concurrent non‐endocrine immune‐mediated diseases

2021 ◽  
Author(s):  
Margaux Kuijlaars ◽  
Donald A. Yool ◽  
Alison E. Ridyard
Keyword(s):  
Standard Poodle ◽  
Autoimmune Polyendocrine Syndrome ◽  
Immune Mediated

scholarly journals The altered circadian pattern of basal insulin requirements – an early marker of autoimmune polyendocrine syndromes in type 1 diabetes mellitus

2020 ◽  
Vol 54 (2) ◽  
pp. 126-132
Author(s):  
Maria Pallayova ◽  
Dagmar Breznoscakova
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Basal Insulin ◽  
Late Afternoon ◽  
Early Marker ◽  
Insulin Requirements ◽  
Autoimmune Polyendocrine Syndrome ◽  
Immune Mediated

AbstractObjectives. The purpose of the present paper is to propose and introduce novel biomarkers of autoimmune polyendocrine syndromes that are relevant to the early diagnosis and optimal medical management of the patients who already suffer from type 1 diabetes mellitus.Methods. We hypothesize and demonstrate on a case study that various organ-specific autoimmune endocrinopathies can result in lowered basal insulin requirements, leading to unexplained hypoglycemia.Results. It can be hypothesized that hypothyroidism in patients with type 1 diabetes mellitus may deteriorate glycemic control and can lead to an increased rate of hypoglycemia, particularly the overnight and morning hypoglycemia. Thus, the decreased requirements for particularly overnight basal insulin can be an early marker of the autoimmune polyendocrine syndrome-3 with subclinical autoimmune thyroiditis in immune-mediated type 1 diabetes mellitus. Further, it could be proposed that unexplained hypoglycemia during the late afternoon or evening could be an early marker of the autoimmune polyendocrine syndrome-2 with subclinical autoimmune Addison disease in immune-mediated type 1 diabetes mellitus. As a result, an altered circadian pattern of basal insulin requirements can occur, characterized by a decreased late afternoon basal insulin rate.Conclusions. After exclusion of other causes, the unexplained reoccurring hypoglycemia can be a remarkable feature of autoimmune polyendocrine syndromes in immune-mediated type 1 diabetes mellitus on intensive insulin replacement therapy.

scholarly journals Perilipin-1 autoantibodies linked to idiopathic lipodystrophy in the setting of two distinct breaks in immune tolerance

2021 ◽  
Author(s):  
Caleigh Mandel-Brehm ◽  
Sara E Vazquez ◽  
Christopher Liverman ◽  
Mickie Cheng ◽  
Zoe Quandt ◽  
...  
Keyword(s):  
Lipid Droplet ◽  
Immune Tolerance ◽  
Radioligand Binding ◽  
Human Subjects ◽  
Case Reports ◽  
Human Case ◽  
Autoimmune Polyendocrine Syndrome ◽  
Immune Mediated ◽  
Perilipin 1 ◽  
Lipid Droplet Protein

Background: Acquired lipodystrophy is often characterized as an idiopathic subtype of lipodystrophy. Despite suspicion of an immune-mediated pathology, biomarkers such as autoantibodies are generally lacking. Methods: Here, we used an unbiased proteome-wide screening approach to identify autoantibodies to the adipocyte specific lipid droplet protein Perilipin-1 in a murine model of Autoimmune Polyendocrine Syndrome 1 (APS1). We then tested for PLIN1 autoantibodies in human subjects with lipodystrophy with two independent severe breaks in immune tolerance (including APS1) along with controls using a specific Radioligand Binding Assay and indirect immunofluorescence on fat tissue. Results: We identified autoantibodies to the lipid-droplet protein Perilipin-1 (PLIN1) in two human case reports including the first reported case of human APS1 with acquired lipodystrophy. Further, we extend PLIN1 autoantibodies to a second non-APS1 patient who acquired lipodystrophy as an immune-related adverse event following cancer immunotherapy. Conclusion: These data suggest that PLIN1 autoantibodies may represent a unifying marker of autoimmune lipodystrophy.

Immune-mediated experimental chronic pancreatitis

2001 ◽  
Vol 120 (5) ◽  
pp. A720-A720
Author(s):  
K RIACKEHEER ◽  
G SPARMANN ◽  
H KLEINE ◽  
H WEBER ◽  
S LIEBE ◽  
...  
Keyword(s):  
Chronic Pancreatitis ◽  
Immune Mediated ◽  
Experimental Chronic Pancreatitis

404: Immune Mediated Survival Advantage and Primary Tumor Control of Cryoablation Compared to Nephrectomy in a Murine Model of Advanced Renal Cancer

2006 ◽  
Vol 175 (4S) ◽  
pp. 132-132 ◽  
Author(s):  
Sean P. Hedican ◽  
Eric R. Wilkinson ◽  
Thomas F. Warner ◽  
Fred T. Lee ◽  
Stephen Y. Nakada
Keyword(s):  
Renal Cancer ◽  
Murine Model ◽  
Primary Tumor ◽  
Survival Advantage ◽  
Tumor Control ◽  
Advanced Renal Cancer ◽  
Immune Mediated

Abstract #1043 A Case of Immune-Mediated Hyperthyroidism Secondary to Atezolizumab Use

2018 ◽  
Vol 24 ◽  
pp. 240
Author(s):  
Zaib Khan ◽  
Khawla Ali ◽  
Carmen Polanco ◽  
Vinni Makin
Keyword(s):  
Immune Mediated

A new mouse model of sclerosing cholangitis combining toxic and immune mediated bile duct injury

2015 ◽  
Vol 53 (12) ◽  
Author(s):  
F Glaser ◽  
B Engel ◽  
C John ◽  
T Krech ◽  
A Carambia ◽  
...  
Keyword(s):  
Bile Duct ◽  
Mouse Model ◽  
Bile Duct Injury ◽  
Sclerosing Cholangitis ◽  
Immune Mediated
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