scholarly journals In-vitro DNA binding and antimicrobial studies of trivalent transition metal ion based macrocyclic complexes

2019 ◽  
Vol 57 (5) ◽  
pp. 543-551
Author(s):  
Vikas Sangwan ◽  
D. P. Singh
Keyword(s):  
Dna Binding ◽  
Transition Metal ◽  
Metal Ion ◽  
Macrocyclic Complexes ◽  
Transition Metal Ion ◽  
Antimicrobial Studies

TRANSITION METAL ION COMPLEXES AS POTENTIAL ANTITUMOR AGENTS

2021 ◽  
Author(s):  
Biljana Petrović ◽  
Keyword(s):  
Antitumor Activity ◽  
Transition Metal ◽  
Metal Ion ◽  
Antitumor Agents ◽  
Platinum Complex ◽  
Platinum Complexes ◽  
Metal Ion Complexes ◽  
Transition Metal Ion ◽  
Potential Antitumor

Discovery of the antitumor activity of platinum complex, cisplatin, cis-Pt(NH3)2Cl2, and later carboplatin and oxaliplatin, led to the intensive investigation of the potential antitumor activity of the huge number of platinum complexes. Furthermore, it is well-known that platinum complexes express toxicity, numerous side effects and resistance, so the scientists make a lot of efforts to synthetize, beside Pt(II) and Pt(IV), other non-platinum compounds with potential antitumor activity, such as Pd(II), Ru(II/III) and Au(III) complexes. The goal of this study is to summarize the results of the investigation of the interactions between some mononuclear, homo- and hetero-polynuclear Pt(II), Pd(II), Ru(II/III) and Au(III) complexes with different sulfur- and nitrogen-donor biologically relevant nucleophiles. Among mononuclear complexes, the compounds with aromatic terpy (tepyridine) or bpma (bis-(2- pyridylmethyl)amine) and aliphatic dien (diethylentriamine) nitrogen-containing inert ligands were studied. Different homo- and hetero-polynuclear complexes with pz (pyrazine) or 4,4’-bipy (4,4’- bipyridine) as bridging and mostly en (ethylenediamine), bipy (2,2’-bipyridine) and dach (trans-1,2- diaminocyclohexane) as inert ligands were studied as well. The research was focused on the connection between the structure and the mechanisms of interactions with different biomolecules, such as L- cysteine (L-Cys), L-methionine (L-Met), tripeptide glutathione (GSH), guanosine-5’-monophosphate (5’-GMP), DNA and bovine serum albumin (BSA). Some of these complexes were selected for in vitro studies of the cytotoxicity on different tumor cell lines. Observed results contribute a lot as a guidance for the future design and determination of the structure-activity relationship (SAR) of different transition metal ion complexes.

6-Gingerol prevents free transition metal Ion [Fe (Ii)] Induced free radicals mediated alterations by In vitro and Ndv growth in chicken eggs by In ovo

2018 ◽  
Vol 14 (55) ◽  
pp. 167
Author(s):  
GanjikuntaVenkata Subbaiah ◽  
KesireddySathyavelu Reddy ◽  
Yagani JayavardhanaRao ◽  
Bhasha Shanmugam ◽  
Sahukari Ravi ◽  
...  
Keyword(s):  
Free Radicals ◽  
Transition Metal ◽  
Metal Ion ◽  
In Ovo ◽  
Transition Metal Ion ◽  
Free Transition ◽  
Chicken Eggs

Transition-metal ion-mediated morphological transformation of pyridine-based peptide nanostructures

2021 ◽  
Vol 45 (1) ◽  
pp. 153-161
Author(s):  
Narendra Singh ◽  
Ramesh Singh ◽  
Swati Sharma ◽  
Khushboo Kesharwani ◽  
Khashti Ballabh Joshi ◽  
...  
Keyword(s):  
Transition Metal ◽  
Metal Ion ◽  
Chemical Structure ◽  
Morphological Transformation ◽  
Transition Metal Ion

Pyridine-mediated constitutionally isomeric artificial metallopeptides possess remarkable advantages over the natural counterparts mainly due to their tailor-made chemical structure.

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