scholarly journals Suspected triclabendazole resistance in ewes with chronic fasciolosis

2021 ◽  
Vol 188 (8) ◽  
pp. 300-303
Keyword(s):  
Triclabendazole Resistance

scholarly journals Lack of efficacy of triclabendazole against Fasciola hepatica is present on sheep farms in three regions of England, and Wales

2019 ◽  
Vol 184 (16) ◽  
pp. 502-502 ◽  
Author(s):  
Juriah Kamaludeen ◽  
John Graham-Brown ◽  
Nathalie Stephens ◽  
Josephine Miller ◽  
Alison Howell ◽  
...  
Keyword(s):  
Fasciola Hepatica ◽  
Lower Percentage ◽  
England And Wales ◽  
Spatially Correlated ◽  
Reduction Test ◽  
Faecal Egg Count ◽  
Juvenile Stages ◽  
The Uk ◽  
Triclabendazole Resistance ◽  
Parasite Emergence

The liver fluke Fasciola hepatica is a parasitic trematode that has a major impact on livestock production and human health. Control of F hepatica is difficult and relies on anthelmintics, particularly triclabendazole, due to its efficacy against both adult and juvenile stages of the parasite. Emergence of triclabendazole-resistant F hepatica populations has been reported in a number of countries, including the UK, but the overall prevalence and distribution of triclabendazole resistance is unknown. In this study, the authors established the presence of reduced efficacy of triclabendazole in sheep flocks in England and Wales, using a validated composite faecal egg count reduction test. Seventy-four sheep farms were sampled from Wales, southwest, northwest and northeast England between Autumn 2013 and Spring 2015. F hepatica eggs were detected in samples from 42/74 farms. Evidence of a lack of efficacy of triclabendazole was detected on 21/26 farms on which the faecal egg count reduction test was completed, with faecal egg count reductions ranging from 89 per cent to 0per cent. Regression analysis suggested that both prevalence of F hepatica and lack of efficacy of triclabendazole were spatially correlated, with higher faecal egg counts and lower percentage reductions on farms located in the northwest of England, and Wales. Overall, the results show that reduced efficacy of triclabendazole is present across England and Wales, with a complete lack of therapeutic efficacy observed on 9/26 farms.

scholarly journals Current Threat of Triclabendazole Resistance in Fasciola hepatica

2016 ◽  
Vol 32 (6) ◽  
pp. 458-469 ◽  
Author(s):  
Jane M. Kelley ◽  
Timothy P. Elliott ◽  
Travis Beddoe ◽  
Glenn Anderson ◽  
Philip Skuce ◽  
...  
Keyword(s):  
Fasciola Hepatica ◽  
Triclabendazole Resistance

An experimental study on triclabendazole resistance of Fasciola hepatica in sheep

2001 ◽  
Vol 95 (1) ◽  
pp. 37-43 ◽  
Author(s):  
C.P.H Gaasenbeek ◽  
L Moll ◽  
J.B.W.J Cornelissen ◽  
P Vellema ◽  
F.H.M Borgsteede
Keyword(s):  
Experimental Study ◽  
Fasciola Hepatica ◽  
Triclabendazole Resistance

Understanding triclabendazole resistance

2007 ◽  
Vol 82 (2) ◽  
pp. 104-109 ◽  
Author(s):  
G.P. Brennan ◽  
I. Fairweather ◽  
A. Trudgett ◽  
E. Hoey ◽  
McCoy ◽  
...  
Keyword(s):  
Triclabendazole Resistance

Identification of putative markers of triclabendazole resistance by a genome-wide analysis of genetically recombinant Fasciola hepatica

Parasitology ◽  
2013 ◽  
Vol 140 (12) ◽  
pp. 1523-1533 ◽  
Author(s):  
J. HODGKINSON ◽  
K. CWIKLINSKI ◽  
N. J. BEESLEY ◽  
S. PATERSON ◽  
D. J. L. WILLIAMS
Keyword(s):  
Genetic Resources ◽  
Fasciola Hepatica ◽  
Genome Wide Analysis ◽  
Extensive Analysis ◽  
Genome Wide ◽  
A Genome ◽  
Genetic Mechanisms ◽  
Triclabendazole Resistance

SUMMARYDespite years of investigation into triclabendazole (TCBZ) resistance in Fasciola hepatica, the genetic mechanisms responsible remain unknown. Extensive analysis of multiple triclabendazole-susceptible and -resistant isolates using a combination of experimental in vivo and in vitro approaches has been carried out, yet few, if any, genes have been demonstrated experimentally to be associated with resistance phenotypes in the field. In this review we summarize the current understanding of TCBZ resistance from the approaches employed to date. We report the current genomic and genetic resources for F. hepatica that are available to facilitate novel functional genomics and genetic experiments for this parasite in the future. Finally, we describe our own non-biased approach to mapping the major genetic loci involved in conferring TCBZ resistance in F. hepatica.

Raising the bar on reporting 'triclabendazole resistance'

2011 ◽  
Vol 168 (19) ◽  
pp. 514-515 ◽  
Author(s):  
I. Fairweather
Keyword(s):  
Triclabendazole Resistance
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