scholarly journals P21.08: Monochorionic twins with selective intrauterine growth restriction: how to counsel patients in the era of invasive fetal therapy

2011 ◽  
Vol 38 (S1) ◽  
pp. 238-239
Author(s):  
C. Rodo ◽  
A. Silvia ◽  
M. Sanchez-Duran ◽  
T. Higueras Sanz ◽  
E. Carreras
Keyword(s):  
Intrauterine Growth Restriction ◽  
Growth Restriction ◽  
Fetal Therapy ◽  
Monochorionic Twins ◽  
Intrauterine Growth

Strategies for intra-amniotic administration of fetal therapy in a rabbit model of intrauterine growth restriction

2021 ◽  
pp. 153537022110035
Author(s):  
Mari Kinoshita ◽  
Fàtima Crispi ◽  
Carla Loreiro ◽  
Eduard Gratacós ◽  
Míriam Illa ◽  
...  
Keyword(s):  
Intrauterine Growth Restriction ◽  
Intraperitoneal Injection ◽  
Rabbit Model ◽  
Osmotic Pump ◽  
Growth Restriction ◽  
Technical Failure ◽  
Fetal Therapy ◽  
Amniotic Cavity ◽  
Intrauterine Growth ◽  
Fetal Survival

Intrauterine growth restriction affects up to 10% of all pregnancies, leading to fetal programming with detrimental consequences for lifelong health. However, no therapeutic strategies have so far been effective to ameliorate these consequences. Our previous study has demonstrated that a single dose of nutrients administered into the amniotic cavity, bypassing the often dysfunctional placenta via intra-amniotic administration, improved survival at birth but not birthweight in an intrauterine growth restriction rabbit model. The aim of this study was to further develop an effective strategy for intra-amniotic fetal therapy in an animal model. Intrauterine growth restriction was induced by selective ligation of uteroplacental vessels on one uterine horn of pregnant rabbits at gestational day 25, and fetuses were delivered by cesarean section on GD30. During the five days of intrauterine growth restriction development, three different methods of intra-amniotic administration were used: continuous intra-amniotic infusion by osmotic pump, multiple intra-amniotic injections, and single fetal intraperitoneal injection. Technical feasibility, capability to systematically reach the fetus, and survival and birthweight of the derived offspring were evaluated for each technique. Continuous intra-amniotic infusion by osmotic pump was not feasible owing to the high occurrence of catheter displacement and amnion rupture, while methods using two intra-amniotic injections and one fetal intraperitoneal injection were technically feasible but compromised fetal survival. Taking into account all the numerous factors affecting intra-amniotic fetal therapy in the intrauterine growth restriction rabbit model, we conclude that an optimal therapeutic strategy with low technical failure and positive fetal impact on both survival and birthweight still needs to be found.

Is computerized cardiotocography useful in monochorionic twins with selective intrauterine growth restriction?

2020 ◽  
pp. 1-6
Author(s):  
Anouk Bertrang Warncke ◽  
Sibylle Zbären ◽  
Daniele Bolla ◽  
Marc Baumann ◽  
Beatrice Mosimann ◽  
...  
Keyword(s):  
Intrauterine Growth Restriction ◽  
Growth Restriction ◽  
Monochorionic Twins ◽  
Intrauterine Growth

scholarly journals Maternal-Fetal Work-up and Management in Intrauterine Growth Restriction (IUGR)

2010 ◽  
Vol 4 (4) ◽  
pp. 427-432
Author(s):  
Narendra Malhotra ◽  
JP Rao ◽  
Randhir Puri
Keyword(s):  
Intrauterine Growth Restriction ◽  
Perinatal Outcome ◽  
Color Doppler ◽  
Therapeutic Strategies ◽  
Growth Restriction ◽  
Future Generations ◽  
Monochorionic Twins ◽  
Intrauterine Growth ◽  
Work Up

ABSTRACT Intrauterine growth restriction remains befundling problem in obstetrics, dependent on multifactorial, diverse, intrinsic fetal conditions as well as many maternal and environmental factors. Ultrasonography with color doppler assesmenent remains the only tool for follow-up and diagnosis. Multidisciplinary apporach for assesment, mangement, prevention is imperative. Selective IUGR in monochorionic twins needs attention for optimum perinatal outcome. Future intensive research is desired to establish preventive, diagnostic and therapeutic strategies for IUGR, perhaps affecting the health of future generations.

scholarly journals Right Ventricular Outflow Tract Obstruction in Monochorionic Twins with Selective Intrauterine Growth Restriction

2012 ◽  
Vol 2012 ◽  
pp. 1-4
Author(s):  
S. B. de Haseth ◽  
M. C. Haak ◽  
A. A. W. Roest ◽  
M. E. B. Rijlaarsdam ◽  
D. Oepkes ◽  
...  
Keyword(s):  
Right Ventricular ◽  
Intrauterine Growth Restriction ◽  
Right Ventricular Outflow Tract ◽  
Ventricular Outflow Tract ◽  
Outflow Tract ◽  
Growth Restriction ◽  
Monochorionic Twins ◽  
Monochorionic Twin ◽  
Intrauterine Growth ◽  
Ventricular Outflow Tract Obstruction

Monochorionic twin pregnancies are at increased risk of perinatal mortality and morbidity due to twin-twin transfusion syndrome (TTTS), selective intrauterine growth restriction (sIUGR), and higher incidence of congenital heart malformations. The incidence of right ventricular outflow tract obstruction (RVOTO) in recipients with TTTS is known to be higher than in the general population. There is limited data on the risk of RVOTO in monochorionic twins with sIUGR. We report a case of RVOTO in the larger twin in a monochorionic twin pregnancy with sIUGR, treated successfully with balloon dilatation after birth.

Sign in / Sign up

Export Citation Format

Share Document