scholarly journals P05.08: Isolated right diaphragmatic hernia mimicking congenital heart disease in utero

2011 ◽  
Vol 38 (S1) ◽  
pp. 182-183
Author(s):  
M. Begam ◽  
M. Hamdan ◽  
G. N. Bekdache ◽  
F. Chedid ◽  
H. Mirghani
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Diaphragmatic Hernia ◽  
Congenital Heart ◽  
In Utero ◽  
Right Diaphragmatic Hernia

FUNCTIONAL ASPECTS OF CONGENITAL HEART DISEASE IN UTERO

1994 ◽  
Vol 22 (s1) ◽  
pp. 51-53
Author(s):  
M. Marasini ◽  
A. Rimini ◽  
F. Conti ◽  
G. Pongiglione
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Congenital Heart ◽  
In Utero ◽  
Functional Aspects

OP06.13: Current outcome of congenital heart disease diagnosed in utero

2007 ◽  
Vol 30 (4) ◽  
pp. 475-476
Author(s):  
D. Prandstraller ◽  
A. Perolo ◽  
A. Donti ◽  
G. D. Gargiulo ◽  
F. M. Picchio ◽  
...  
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Congenital Heart ◽  
In Utero

Umbilical Cord Blood Gas in Newborns with Prenatal Diagnosis of Congenital Heart Disease: Insight into In-Utero and Delivery Hemodynamics

2019 ◽  
Vol 40 (8) ◽  
pp. 1575-1583
Author(s):  
April D. Adams ◽  
Nimisha Aggarwal ◽  
Sara N. Iqbal ◽  
Lauren Tague ◽  
Kami Skurow-Todd ◽  
...  
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Prenatal Diagnosis ◽  
Cord Blood ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Congenital Heart ◽  
In Utero ◽  
Blood Gas ◽  
Insight Into

Abstract 18446: Treatment With Tetrahydrobiopterin Decreases White Matter Injury in a Mouse Model for In Utero Hypoxia in Congenital Heart Disease

Circulation ◽  
2015 ◽  
Vol 132 (suppl_3) ◽  
Author(s):  
Jennifer Romanowicz ◽  
Ludmila Korotcova ◽  
Paul Morton ◽  
Amrita Cheema ◽  
Vittorio Gallo ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Congenital Heart Disease ◽  
Heart Disease ◽  
White Matter ◽  
Nitric Oxide Synthase ◽  
Congenital Heart ◽  
In Utero ◽  
Complex Congenital Heart Disease ◽  
Brain White Matter ◽  
Oxide Synthase

Introduction: Reduced oxygen delivery in complex congenital heart disease (CHD) can lead to brain white matter (WM) injury in utero. Currently, no treatment exists. Tetrahydrobiopterin (BH4) is a cofactor for neuronal nitric oxide synthase, and in its absence, toxic peroxynitrite production is favored. Hypoxia activates nitric oxide synthase, which reduces BH4 availability. Hypothesis: Decreased BH4 levels underlie WM injury in the fetus with CHD, and treatment with BH4 will reduce this injury. Methods: Mice were divided into three groups: normoxic controls (Nx), hypoxic (Hx), and hypoxic with BH4 treatment (Hx-BH4). Hx and Hx-BH4 mice were kept at 10.5% FiO2 from postnatal day 3 to 11--a period of WM development equivalent to the 3rd trimester in humans. Brain BH4 levels were quantified and compared between Nx (n=11) and Hx (n=12). Densities of cells expressing CNP (marker of oligodendrocytes--cells responsible for myelination) and Caspase3 (apoptosis marker) were quantified in three WM regions and compared between groups (n=3-6 each). Western blot detected myelin basic protein (myelin marker). Results: Brain BH4 levels were depleted in Hx compared to Nx (-38.4%, p=0.02). CNP+ oligodendrocytes increased after Hx compared to Nx (Fig.1a), consistent with hypoxia-induced proliferation seen previously. BH4 treatment did not limit this proliferation (Fig.1a). Hx had increased WM apoptosis (Fig.1b), which decreased with BH4 treatment (Fig.1b). Remarkably, there was no difference in WM caspase3+ cells between Nx and Hx-BH4 (Fig.1b). There was no difference in effect across WM region. Finally, loss of myelin with hypoxia was mitigated by BH4 treatment (Fig.1c). Conclusions: Our results show that suboptimal BH4 levels influence hypoxic WM injury. BH4 treatment of phenylketonuria is safe during pregnancy, thus maternal BH4 therapy is feasible. Our data demonstrate that repurposing BH4 for use during fetal brain development has potential to limit WM injury in CHD.

Congenital Heart Disease and Fetal Thoracoabdominal Anomalies: Associations in Utero and the Importance of Cytogenetic Analysis

1991 ◽  
Vol 8 (06) ◽  
pp. 411-416 ◽  
Author(s):  
Mark Fogel ◽  
Joshua Copel ◽  
Mark Cullen ◽  
John Hobbins ◽  
Charles Kleinman
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Cytogenetic Analysis ◽  
Congenital Heart ◽  
In Utero

scholarly journals Pancreatic Agenesis with Congenital Diaphragmatic Hernia and Congenital Heart Disease: A Case Report

2013 ◽  
Vol 03 (02) ◽  
pp. 119-122 ◽  
Author(s):  
Tomohiro Takeda ◽  
Yoshiya Hisaeda ◽  
Atsushi Hirota ◽  
Syusuke Amagata ◽  
Yuko Sakurai ◽  
...  
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Case Report ◽  
Congenital Diaphragmatic Hernia ◽  
Diaphragmatic Hernia ◽  
Congenital Heart ◽  
Pancreatic Agenesis

scholarly journals Reversed shunting across the ductus arteriosus or atrial septum in utero heralds severe congenital heart disease

1996 ◽  
Vol 27 (2) ◽  
pp. 481-486 ◽  
Author(s):  
Richard A. Berning ◽  
Norman H. Silverman ◽  
Maria Villegas ◽  
David J. Sahn ◽  
Gerard R. Martin ◽  
...  
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Congenital Heart ◽  
Ductus Arteriosus ◽  
In Utero ◽  
Atrial Septum ◽  
Severe Congenital Heart Disease
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