scholarly journals OC16.03: Midbrain curvature for the detection of spina bifida in the first trimester of pregnancy

2011 ◽  
Vol 38 (S1) ◽  
pp. 30-30
Author(s):  
G. Lau ◽  
J. G. Acuna ◽  
I. Solt ◽  
C. Morales ◽  
S. Beauchamp ◽  
...  
Keyword(s):  
Spina Bifida ◽  
First Trimester ◽  
First Trimester Of Pregnancy

Screening for fetal spina bifida by ultrasound examination in the first trimester of pregnancy using fetal biparietal diameter

2012 ◽  
Vol 207 (4) ◽  
pp. 306.e1-306.e5 ◽  
Author(s):  
Jean-Pierre Bernard ◽  
Howard S. Cuckle ◽  
Julien J. Stirnemann ◽  
Laurent J. Salomon ◽  
Yves Ville
Keyword(s):  
Spina Bifida ◽  
Ultrasound Examination ◽  
First Trimester ◽  
Biparietal Diameter ◽  
First Trimester Of Pregnancy

Maxillo–occipital line: a sonographic marker for screening of open spina bifida in the first trimester of pregnancy

2018 ◽  
Vol 32 (24) ◽  
pp. 4073-4079 ◽  
Author(s):  
Jayshree Ramkrishna ◽  
Edward Araujo Júnior ◽  
Alberto Borges Peixoto ◽  
Fabricio Da Silva Costa ◽  
Simon Meagher
Keyword(s):  
Spina Bifida ◽  
First Trimester ◽  
First Trimester Of Pregnancy ◽  
Open Spina Bifida

First trimester cerebral appearance in the presence of closed spina bifida with myelomeningocele, part of the oeis complex

2020 ◽  
Vol 13 (10) ◽  
pp. e235395
Author(s):  
Delia Roxana Ungureanu ◽  
Lucian George Zorila ◽  
Razvan Grigoras Capitanescu ◽  
Dominic Gabriel Iliescu
Keyword(s):  
Spinal Cord ◽  
Spina Bifida ◽  
First Trimester ◽  
Cerebrospinal Fluid Leakage ◽  
Good Neurological Outcome ◽  
Careful Evaluation ◽  
First Trimester Of Pregnancy ◽  
Large Skin ◽  
Open Spina Bifida ◽  
Secondary Signs

Our communication presents a prenatally detected case with severe spinal defect detected in the first trimester of pregnancy, accompanied by a large skin-covered myelomeningocele but normal cranio-cerebral structural appearance.These findings suggest that in the first trimester, the extent of the spinal defect, the cerebrospinal fluid leakage to a large, but skin-covered, meningocele and fixation of the spinal cord at the lesion are not sufficient to determine downward hindbrain displacement and the development of secondary signs for open spina bifida.Therefore, we suggest a careful evaluation of the fetal cerebral features if a meningocele is detected. The presence of the skin covering the lesion may not be evident in the first trimester, but the absence of intracranial open spina bifida markers may indicate a ‘closed’ spinal defect, which generally associates a good neurological outcome. Also, studies aimed to investigate the accuracy of the intracranial features for open spina bifida detection should consider the possibility of ‘closed’ myelomeningoceles to avoid incorrect correlations.

scholarly journals Normal intracranial BS/BSOB ratio values in the first trimester of single gestations with live fetuses in a Korean population

2017 ◽  
Vol 19 (2) ◽  
pp. 190
Author(s):  
Sung Hee Yang ◽  
Hyun Sook An ◽  
Jin Soo Lee ◽  
Changsoo Kim
Keyword(s):  
Spina Bifida ◽  
First Trimester ◽  
Cross Sectional Study ◽  
Korean Women ◽  
Sectional Study ◽  
Cross Sectional ◽  
Gestational Period ◽  
Reference Marker ◽  
Routine Measurement ◽  
First Trimester Of Pregnancy

Aim: The purpose of this study was to determine the normal length of the brainstem (BS) in Korean fetuses and to evaluatethe usefulness of the routine measurement of BS size in the first trimester of pregnancy for the early detection of spina bifida.Material and methods: A total of 2,621 normal singleton pregnant Korean women at 10+6 to 13+6 weeks of gestation were selected for this retrospective cross-sectional study. Ultrasonography was used to measure the length of the longest vertical depth diameter of the BS and brainstem-occipital bone (BSOB) in order to obtain the BS to BSOB ratio.Results: The best indicators for spina bifida ranged from 1.00±0.24 mm to 4.70±0.46 mm for the BS and from 2.90±0.36 mm to 8.50±0.92 mm for the BSOB. For the gestational period, BS (R=0.70) and BSOB (R=0.81) values were considered statistically significant (p<.0001). The value of the BS to BSOB ratio was <1.0 in normal fetuses, and was not correlated with the gestational age.Conclusion: Measurement of BS and BSOB diameter in the first trimester is thought to provide the best reference marker for evaluating the posterior brain for diagnosis of spina bifida.

scholarly journals Maternal PM10 Exposure Increases Risk for Spina Bifida: A Population-Based Case-Control Study

2021 ◽  
Vol 9 ◽  
Author(s):  
Huan Li ◽  
Yan-Hong Huang ◽  
Jing Li ◽  
Shu Liu ◽  
Yan-Ling Chen ◽  
...  
Keyword(s):  
Spina Bifida ◽  
Ambient Air ◽  
First Trimester ◽  
Population Based ◽  
Liaoning Province ◽  
Sensitivity Analyses ◽  
Propensity Score Methods ◽  
First Trimester Of Pregnancy ◽  
Exposure Windows ◽  
Control Study

Limited studies have focused on the impact of ambient air pollution on spina bifida. A population-based case-control study was conducted in Liaoning Province, China to assess the associations between maternal PM10 exposures in various exposure windows and spina bifida risk. Data on spina bifida cases born between 2010 and 2015 were available from the Maternal and Child Health Certificate Registry of Liaoning Province. Controls were a random sample of healthy livebirths without any birth defects delivered in the selected five cities during 2010–2015. Ambient air monitoring data for PM10 were obtained from 75 monitoring stations in Liaoning Province. The multivariable logistic regression models were established to calculate adjusted odds ratios (OR) and 95% confidence intervals (CI). We further performed sensitivity analyses by using three propensity score methods. A total of 749 spina bifida cases and 7,950 controls were included. After adjusting for potential confounders, spina bifida was associated with a 10 μg/m3 increment in PM10 during the first trimester of pregnancy (adjusted OR = 1.06, 95% CI: 1.00–1.12) and the 3 months before pregnancy (adjusted OR = 1.12, 95% CI: 1.06–1.19). The adjusted ORs in the final model for the highest vs. the lowest quartile were 1.51 (95% CI: 1.04–2.19) for PM10 during the first trimester of pregnancy and 2.01 (95% CI: 1.43–2.81) for PM10 during the 3 months before pregnancy. Positive associations were found between PM10 exposures during the single month exposure windows and spina bifida. Sensitivity analyses based on two propensity score methods largely reported similar positive associations. Our findings support the evidence that maternal PM10 exposure increases the risk of spina bifida in offspring. Further, validation with a prospective design and a more accurate exposure assessment is warranted.

FRACTIONAL DETERMINATIONS OF URINARY 17-KETOSTEROIDS IN HYPEREMESIS GRAVIDARUM

1962 ◽  
Vol 41 (1) ◽  
pp. 123-128 ◽  
Author(s):  
Pentti A. Järvinen ◽  
Sykkö Pesonen ◽  
Pirkko Väänänen
Keyword(s):  
Hyperemesis Gravidarum ◽  
First Trimester ◽  
Control Group ◽  
Before And After ◽  
Daily Urine ◽  
First Trimester Of Pregnancy ◽  
The Difference

ABSTRACT The fractional determination of 17-ketosteroids in the daily urine was performed in nine cases of hyperemesis gravidarum and in four control cases, in the first trimester of pregnancy both before and after corticotrophin administration. The excretion of total 17-KS is similar in the two groups. Only in the hyperemesis group does the excretion of total 17-KS increase significantly after corticotrophin administration. The fractional determination reveals no difference between the two groups of patients with regard to the values of the fractions U (unidentified 17-KS), A (androsterone) and Rest (11-oxygenated 17-KS). The excretion of dehydroepiandrosterone is significantly higher in the hyperemesis group than in the control group. The excretion of androstanolone seems to be lower in the hyperemesis group than in the control group, but the difference is not statistically significant. The differences in the correlation between dehydroepiandrosterone and androstanolone in the two groups is significant. The high excretion of dehydroepiandrosterone and low excretion of androstanolone in cases of hyperemesis gravidarum is a sign of adrenal dysfunction.

Impact of TSH during the first trimester of pregnancy in obstetric and fetal complications: Usefulness of 2.5 mIU/l cut-off value

2018 ◽  
Author(s):  
Berta Soldevila ◽  
Marta Hernandez ◽  
Carolina Lopez ◽  
Laura Cacenarro ◽  
Maria Martinez-Barahona ◽  
...  
Keyword(s):  
First Trimester ◽  
Fetal Complications ◽  
First Trimester Of Pregnancy

Relationship between TSH values in the first trimester of pregnancy and obstetric and neonatal complications

2018 ◽  
Author(s):  
Beatriz Torres Moreno ◽  
Gabriela Castillo Carvajal ◽  
Lucrecia Vegara Fernandez ◽  
del Val Teresa Lopez ◽  
Victoria Alcazar Lazaro ◽  
...  
Keyword(s):  
First Trimester ◽  
Neonatal Complications ◽  
First Trimester Of Pregnancy
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