P17.03: First trimester biochemical screening combined with fetal nuchal translucency, nasal bone and maternal age for Down syndrome in singelton pregnancies

2010 ◽  
Vol 36 (S1) ◽  
pp. 234-234
Author(s):  
K. Natasa ◽  
Z. Mikovic ◽  
M. Marinkovic ◽  
B. Damnjanovic-Pazin ◽  
Z. Milovanovic ◽  
...  
Keyword(s):  
Down Syndrome ◽  
Maternal Age ◽  
Nasal Bone ◽  
First Trimester ◽  
Nuchal Translucency ◽  
Biochemical Screening

scholarly journals First Trimester Genetic Sonogram for Screening Fetal Down Syndrome: a Population-based Study

2020 ◽  
Author(s):  
Kuntharee Traisrisilp ◽  
Supatra Sirichotiyakul ◽  
Fuanglada Tongprasert ◽  
Kasemsri Srisupun ◽  
Suchaya Luewan ◽  
...  
Keyword(s):  
Down Syndrome ◽  
Pregnant Women ◽  
False Positive ◽  
Detection Rate ◽  
False Positive Rate ◽  
Nasal Bone ◽  
First Trimester ◽  
Nuchal Translucency ◽  
Ductus Venosus ◽  
Positive Rate

Abstract Background: To evaluate the performance of first trimester sonomarkers in the detection of fetal Down syndrome among Thai pregnant womenMethods: Pregnant women at 11-13+6 weeks’ gestation underwent ultrasound examination for assessment of nuchal translucency (NT), nasal bone (NB), tricuspid regurgitation (TR), and abnormal ductus venosus (aDV) Doppler waveforms. The women were followed up for final outcomes. Fetal abnormalities other than trisomy 21 were excluded. The performances of each sonomarker and their combinations in predicting fetal Down syndrome were calculated.Results: A total of 7,820 pregnant women meeting the inclusion criteria were available for analysis, including 20 cases with fetal Down syndrome and 7,800 unaffected cases. Of the four sonomarkers, NT, as a single sonomarker, had the highest detection rate (55.0% at a false positive rate of about 5%), whereas the remaining single sonomarkers had low detection rate (15-20%). The combination of all sonomarkers had the highest detection rate of 70% but the false positive rate was as high as 10.8%. The combination of NT and NB had a detection rate of 60% with an acceptable false positive rate of 6.9%, whereas the other combinations yielded relatively high false positive rates. Conclusion: The first trimester genetic sonogram in screening for Down syndrome among Asian women is acceptably effective and may be offered to some selected groups of the population. NT is the best sonomarker with a detection rate of 55% at 5% false positive rate and its combination with NB can improve performance with minimal increase in false positive rate.

scholarly journals OC12: First-trimester nuchal translucency and nasal bone assessment for Down syndrome screening at a single centre

2006 ◽  
Vol 28 (4) ◽  
pp. 362-362
Author(s):  
G. Monni ◽  
M. A. Zoppi ◽  
R. M. Ibba ◽  
M. Floris ◽  
F. Manca ◽  
...  
Keyword(s):  
Down Syndrome ◽  
Nasal Bone ◽  
First Trimester ◽  
Nuchal Translucency ◽  
Single Centre ◽  
Bone Assessment ◽  
Down Syndrome Screening
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